The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper.

Abstract : Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the "autisms" [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as "steroid metabolism" and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD.
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Christopher Gillberg, Elisabeth Fernell, Eva Kočovská, Helen Minnis, Thomas Bourgeron, et al.. The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper.. Autism research : official journal of the International Society for Autism Research, 2017, 10 (6), pp.1022-1044. ⟨10.1002/aur.1777⟩. ⟨pasteur-01577984⟩

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