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Journal articles
Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition
V Warrier
1, *
K L Grasby
2
F Uzefovsky
3, 1
R Toro
4, 5
P Smith
1
B Chakrabarti
6
J Khadake
7, 1
E Mawbey-Adamson
1, 7
N Litterman
8
J-J Hottenga
9, 10
G Lubke
11
D I Boomsma
9
N G Martin
2
P K Hatemi
12
S E Medland
2
D A Hinds
8
T Bourgeron
5
S Baron-Cohen
13, 1, *
*
Corresponding author
V Warrier 1
Correspondent author
K L Grasby 2
Author
F Uzefovsky 3, 1
Author
R Toro 4, 5
Author IdHAL : robertotoro ORCID : https://orcid.org/0000-0002-6671-858X
T Bourgeron 5
Author IdHAL : 0000-0003-1748-8551 ORCID : https://orcid.org/0000-0003-1748-8551
S Baron-Cohen 13, 1
Correspondent author
1
CAM - University of Cambridge [UK] (The Old Schools, Trinity Lane, Cambridge CB2 1TN - United Kingdom)
2
QIMR Berghofer Medical Research Institute (300 Herston Rd, Brisbane City QLD 4006 - Australia)
3
BGU - Ben-Gurion University of the Negev (P.O.B. 653 Beer-Sheva - Israel)
4
GHFC (UMR_3571 / U-Pasteur_1) - Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (C3BI / Département de Neuroscience - 25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- UPD7 - Université Paris Diderot - Paris 7 : U-Pasteur_1 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR_3571 (France)
5
Gènes, Synapses et Cognition (25-28 Rue du Docteur Roux 75015 Paris - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR3571 (France)
6
UOR - University of Reading (Whiteknights, PO Box 217, READING, Berkshire, RG6 6AH, - United Kingdom)
7
CUH - Cambridge University Hospitals - NHS (Foundation Trust Cambridge Biomedical Campus Hills Road Cambridge CB2 0QQ - United Kingdom)
- CAM - University of Cambridge [UK] (The Old Schools, Trinity Lane, Cambridge CB2 1TN - United Kingdom)
8
23andMe Inc. (Mountain View, California, U.S.A - United States)
9
VU - Vrije Universiteit Amsterdam [Amsterdam] (De Boelelaan 1105 1081 HV Amsterdam - Netherlands)
10
VU University Medical Center [Amsterdam] (De Boelelaan 1118, 1081 HZ Amsterdam - Netherlands)
11
UND - University of Notre Dame [Indiana] (Notre Dame, Indiana 46556 - United States)
12
Penn State - Pennsylvania State University (201 Old Main, University Park, Pennsylvania 16802 - United States)
- Penn State System (Pennsylvania, PA, USA, Etats-Unis - United States)
13
CPFT - Cambridgeshire & Peterborough NHS Foundation Trust [Cambridge] (Cambridgeshire and Peterborough NHS Foundation Trust
Elizabeth House, Fulbourn Hospital
Cambridge, CB21 5EF - United Kingdom)
Abstract : We conducted a genome-wide meta-analysis of cognitive empathy using the 'Reading the Mind in the Eyes' Test (Eyes Test) in 88,056 research volunteers of European Ancestry (44,574 females and 43,482 males) from 23andMe Inc., and an additional 1497 research volunteers of European Ancestry (891 females and 606 males) from the Brisbane Longitudinal Twin Study. We confirmed a female advantage on the Eyes Test (Cohen's d=0.21, P<2.2 × 10(-16)), and identified a locus in 3p26.1 that is associated with scores on the Eyes Test in females (rs7641347, Pmeta=1.58 × 10(-8)). Common single nucleotide polymorphisms explained 5.8% (95% CI: 4.5%-7.2%; P=1.00 × 10(-17)) of the total trait variance in both sexes, and we identified a twin heritability of 28% (95% CI: 13%-42%). Finally, we identified significant genetic correlation between the Eyes Test and anorexia nervosa, openness (NEO-Five Factor Inventory), and different measures of educational attainment and cognitive aptitude.Molecular Psychiatry advance online publication, 6 June 2017; doi:10.1038/mp.2017.122.
Document type :
Journal articles
Complete list of metadata
https://hal-pasteur.archives-ouvertes.fr/pasteur-01577832
Contributor : Corinne Baran <>
Submitted on : Monday, August 28, 2017 - 11:22:22 AM
Last modification on : Saturday, April 11, 2020 - 1:55:34 AM
Contributor : Corinne Baran <>
Submitted on : Monday, August 28, 2017 - 11:22:22 AM
Last modification on : Saturday, April 11, 2020 - 1:55:34 AM
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mp2017122a.pdf
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License
Identifiers
- HAL Id : pasteur-01577832, version 1
- DOI : 10.1038/mp.2017.122
- PUBMED : 28584286
- PUBMEDCENTRAL : PMC5656177
Collections
PASTEUR | CNRS | UNIV-PARIS7 | USPC | UNIV-PARIS | UP-SCIENCES
Citation
V Warrier, K L Grasby, F Uzefovsky, R Toro, P Smith, et al.. Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition. Molecular Psychiatry, Nature Publishing Group, 2017, advance online publication. ⟨10.1038/mp.2017.122⟩. ⟨pasteur-01577832⟩
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