Active dendritic integration as a mechanism for robust and precise grid cell firing.

Abstract : Understanding how active dendrites are exploited for behaviorally relevant computations is a fundamental challenge in neuroscience. Grid cells in medial entorhinal cortex are an attractive model system for addressing this question, as the computation they perform is clear: they convert synaptic inputs into spatially modulated, periodic firing. Whether active dendrites contribute to the generation of the dual temporal and rate codes characteristic of grid cell output is unknown. We show that dendrites of medial entorhinal cortex neurons are highly excitable and exhibit a supralinear input-output function in vitro, while in vivo recordings reveal membrane potential signatures consistent with recruitment of active dendritic conductances. By incorporating these nonlinear dynamics into grid cell models, we show that they can sharpen the precision of the temporal code and enhance the robustness of the rate code, thereby supporting a stable, accurate representation of space under varying environmental conditions. Our results suggest that active dendrites may therefore constitute a key cellular mechanism for ensuring reliable spatial navigation.
Type de document :
Article dans une revue
Nature Neuroscience, Nature Publishing Group, 2017, 20 (8), pp.1114-1121. 〈10.1038/nn.4582〉
Liste complète des métadonnées

Littérature citée [8 références]  Voir  Masquer  Télécharger

https://hal-pasteur.archives-ouvertes.fr/pasteur-01577058
Contributeur : Christoph Schmidt-Hieber <>
Soumis le : jeudi 24 août 2017 - 17:50:46
Dernière modification le : vendredi 25 août 2017 - 15:03:39

Fichier

Schmidt-Hieber_2017_submitted_...
Fichiers produits par l'(les) auteur(s)

Licence


Distributed under a Creative Commons Paternité - Pas d'utilisation commerciale - Partage selon les Conditions Initiales 4.0 International License

Identifiants

Collections

Citation

Christoph Schmidt-Hieber, Gabija Toleikyte, Laurence Aitchison, Arnd Roth, Beverley A Clark, et al.. Active dendritic integration as a mechanism for robust and precise grid cell firing.. Nature Neuroscience, Nature Publishing Group, 2017, 20 (8), pp.1114-1121. 〈10.1038/nn.4582〉. 〈pasteur-01577058〉

Partager

Métriques

Consultations de la notice

161

Téléchargements de fichiers

83