The ever-growing complexity of the mitochondrial fission machinery.

Abstract : The mitochondrial network constantly changes and remodels its shape to face the cellular energy demand. In human cells, mitochondrial fusion is regulated by the large, evolutionarily conserved GTPases Mfn1 and Mfn2, which are embedded in the mitochondrial outer membrane, and by OPA1, embedded in the mitochondrial inner membrane. In contrast, the soluble dynamin-related GTPase Drp1 is recruited from the cytosol to mitochondria and is key to mitochondrial fission. A number of new players have been recently involved in Drp1-dependent mitochondrial fission, ranging from large cellular structures such as the ER and the cytoskeleton to the surprising involvement of the endocytic dynamin 2 in the terminal abscission step. Here we review the recent findings that have expanded the mechanistic model for the mitochondrial fission process in human cells and highlight open questions.
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Article dans une revue
Cellular and Molecular Life Sciences, Springer Verlag, 2017
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Contributeur : Marie-Therese Vicente <>
Soumis le : jeudi 17 août 2017 - 11:30:43
Dernière modification le : jeudi 11 janvier 2018 - 06:27:34


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  • HAL Id : pasteur-01574994, version 1
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Alessandro Pagliuso, Pascale Cossart, Fabrizia Stavru. The ever-growing complexity of the mitochondrial fission machinery.. Cellular and Molecular Life Sciences, Springer Verlag, 2017. 〈pasteur-01574994〉



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