Manipulation of host membranes by the bacterial pathogens Listeria, Francisella, Shigella and Yersinia.

Javier Pizarro-Cerdá (1) , Alain Charbit (2, 3) , Jost Enninga (4) , Frank Lafont (5) , Pascale Cossart (1)

1 UIBC - Interactions Bactéries-Cellules
2 USPC - Université Sorbonne Paris Cité
3 Inserm U1002 - Pathogénie des infections systémiques
4 Dynamique des Interactions Hôte-Pathogène - Dynamics of Host-Pathogen Interactions
5 Institut Pasteur de Lille

Bacterial pathogens display an impressive arsenal of molecular mechanisms that allow survival in diverse host niches. Subversion of plasma membrane and cytoskeletal functions are common themes associated to infection by both extracellular and intracellular pathogens. Moreover, intracellular pathogens modify the structure/stability of their membrane-bound compartments and escape degradation from phagocytic or autophagic pathways. Here, we review the manipulation of host membranes by Listeria monocytogenes, Francisella tularensis, Shigella flexneri and Yersinia spp. These four bacterial model pathogens exemplify generalized strategies as well as specific features observed during bacterial infection processes.

Keywords: Membrane trafficking; Listeria monocytogenes; Francisella tularensis; Yersinia pseudotuberculosis; Shigella flexneri; Phagocytosis

Domains: Life Sciences [q-bio]

Javier Pizarro-Cerdá, Alain Charbit, Jost Enninga, Frank Lafont, Pascale Cossart. Manipulation of host membranes by the bacterial pathogens Listeria, Francisella, Shigella and Yersinia.. Seminars in Cell and Developmental Biology, 2016, 60, pp.155-167. ⟨10.1016/j.semcdb.2016.07.019⟩. ⟨pasteur-01574039⟩