Nicotinic receptors in the ventral tegmental area promote uncertainty-seeking.

Jérémie Naudé 1 Stefania Tolu 1 Malou Dongelmans 1 Nicolas Torquet 1 Sébastien Valverde 1 Guillaume Rodriguez 1 Stéphanie Pons 2 Uwe Maskos 2 Alexandre Mourot 3, 1 Fabio Marti 3, 1 Philippe Faure 3, 1, *
* Auteur correspondant
1 IBPS - Institut de Biologie Paris Seine
2 Neurobiologie intégrative des Systèmes cholinergiques
3 NPS-06 - Neurophysiologie et comportements = Neurophysiology and Behavior
NPS - Neuroscience Paris Seine
Abstract : Cholinergic neurotransmission affects decision-making, notably through the modulation of perceptual processing in the cortex. In addition, acetylcholine acts on value-based decisions through as yet unknown mechanisms. We found that nicotinic acetylcholine receptors (nAChRs) expressed in the ventral tegmental area (VTA) are involved in the translation of expected uncertainty into motivational value. We developed a multi-armed bandit task for mice with three locations, each associated with a different reward probability. We found that mice lacking the nAChR β2 subunit showed less uncertainty-seeking than their wild-type counterparts. Using model-based analysis, we found that reward uncertainty motivated wild-type mice, but not mice lacking the nAChR β2 subunit. Selective re-expression of the β2 subunit in the VTA was sufficient to restore spontaneous bursting activity in dopamine neurons and uncertainty-seeking. Our results reveal an unanticipated role for subcortical nAChRs in motivation induced by expected uncertainty and provide a parsimonious account for a wealth of behaviors related to nAChRs in the VTA expressing the β2 subunit.
Keywords : Learning algorithms Motivation Reward
Type de document :
Article dans une revue
Nature Neuroscience, Nature Publishing Group, 2016, 19 (3), pp.471-8. 〈10.1038/nn.4223〉
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01573669
Contributeur : Anaïs Victoire <>
Soumis le : jeudi 10 août 2017 - 12:32:07
Dernière modification le : vendredi 31 août 2018 - 08:59:08

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Jérémie Naudé, Stefania Tolu, Malou Dongelmans, Nicolas Torquet, Sébastien Valverde, et al.. Nicotinic receptors in the ventral tegmental area promote uncertainty-seeking.. Nature Neuroscience, Nature Publishing Group, 2016, 19 (3), pp.471-8. 〈10.1038/nn.4223〉. 〈pasteur-01573669〉

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