Skip to Main content Skip to Navigation
New interface
Journal articles

The enemy within: Targeting host–parasite interaction for antileishmanial drug discovery

Abstract : The state of antileishmanial chemotherapy is strongly compromised by the emergence of drug-resistant Leishmania. The evolution of drug-resistant phenotypes has been linked to the parasites’ intrinsic genome instability, with frequent gene and chromosome amplifications causing fitness gains that are directly selected by environmental factors, including the presence of antileishmanial drugs. Thus, even though the unique eukaryotic biology of Leishmania and its dependence on parasite-specific virulence factors provide valid opportunities for chemotherapeutical intervention, all strategies that target the parasite in a direct fashion are likely prone to select for resistance. Here, we review the current state of antileishmanial chemotherapy and discuss the limitations of ongoing drug discovery efforts. We finally propose new strategies that target Leishmania viability indirectly via mechanisms of host–parasite interaction, including parasite-released ectokinases and host epigenetic regulation, which modulate host cell signaling and transcriptional regulation, respectively, to establish permissive conditions for intracellular Leishmania survival.
Document type :
Journal articles
Complete list of metadata

Cited literature [22 references]  Display  Hide  Download
Contributor : Floran Bidault Connect in order to contact the contributor
Submitted on : Friday, July 28, 2017 - 4:21:20 PM
Last modification on : Wednesday, September 28, 2022 - 8:30:25 AM


Publication funded by an institution


Distributed under a Creative Commons Attribution 4.0 International License




Suzanne Lamotte, Gerald F Späth, Najma Rachidi, Eric Prina. The enemy within: Targeting host–parasite interaction for antileishmanial drug discovery. PLoS Neglected Tropical Diseases, 2017, 11 (6), pp.e0005480. ⟨10.1371/journal.pntd.0005480⟩. ⟨pasteur-01570238⟩



Record views


Files downloads