Interferon-Stimulated Genes: A Complex Web of Host Defenses, Annual Review of Immunology, vol.32, issue.1, pp.513-54510, 2014. ,
DOI : 10.1146/annurev-immunol-032713-120231
Immunomodulatory functions of type I interferons, Nature Reviews Immunology, vol.170, pp.125-13510, 2012. ,
DOI : 10.4049/jimmunol.170.10.5195
DAMPs from Cell Death to New Life, Front Immunol, vol.6, issue.422, p.422, 2015. ,
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids, Annual Review of Immunology, vol.32, issue.1, pp.461-48810, 2014. ,
DOI : 10.1146/annurev-immunol-032713-120156
Recognition of Endogenous Nucleic Acids by the Innate Immune System, Immunity, vol.44, issue.4, pp.739-754002, 2016. ,
DOI : 10.1016/j.immuni.2016.04.002
The JAK-STAT Pathway at Twenty, Immunity, vol.36, issue.4, pp.503-514, 2012. ,
DOI : 10.1016/j.immuni.2012.03.013
Interferons and Their Stimulated Genes in the Tumor Microenvironment, Seminars in Oncology, vol.41, issue.2, pp.156-173002, 2014. ,
DOI : 10.1053/j.seminoncol.2014.02.002
Type I interferonopathies???an expanding disease spectrum of immunodysregulation, Seminars in Immunopathology, vol.25, issue.4, pp.349-357, 2015. ,
DOI : 10.1016/j.coi.2012.11.004
Identification of Small Molecule Activators of the Janus Kinase/Signal Transducer and Activator of Transcription Pathway Using a Cell-Based Screen, Biological & Pharmaceutical Bulletin, vol.35, issue.1, pp.65-71, 2012. ,
DOI : 10.1248/bpb.35.65
Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71, International Journal of Antimicrobial Agents, vol.32, issue.4, pp.355-359018, 2008. ,
DOI : 10.1016/j.ijantimicag.2008.04.018
GSK983: A novel compound with broad-spectrum antiviral activity, Antiviral Research, vol.82, issue.1, pp.1-11015, 2008. ,
DOI : 10.1016/j.antiviral.2008.12.015
Isoflavone Agonists of IRF-3 Dependent Signaling Have Antiviral Activity against RNA Viruses, Journal of Virology, vol.86, issue.13, pp.7334-734410, 2012. ,
DOI : 10.1128/JVI.06867-11
ABSTRACT, Journal of Virology, vol.90, issue.5, pp.2372-238710, 2015. ,
DOI : 10.1128/JVI.02202-15
Identification of Small Molecules with Type I Interferon Inducing Properties by High-Throughput Screening, PLoS ONE, vol.31, issue.5, p.49049, 2012. ,
DOI : 10.1371/journal.pone.0049049.g006
High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery, PLoS ONE, vol.3, issue.5, 2012. ,
DOI : 10.1371/journal.pone.0036594.s002
RO 90-7501 Enhances TLR3 and RLR Agonist Induced Antiviral Response, PLoS ONE, vol.7, issue.10, 2012. ,
DOI : 10.1371/journal.pone.0042583.g009
Dual Myxovirus Screen Identifies a Small-Molecule Agonist of the Host Antiviral Response, Journal of Virology, vol.87, issue.20, pp.11076-1108710, 2013. ,
DOI : 10.1128/JVI.01425-13
Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses, PLOS Pathogens, vol.79, issue.12, 2015. ,
DOI : 10.1371/journal.ppat.1005324.s007
Regulators of innate immunity as novel targets for panviral therapeutics, Current Opinion in Virology, vol.2, issue.5, pp.622-628, 2012. ,
DOI : 10.1016/j.coviro.2012.08.009
Stimuler la r??ponse interf??ron de type I avec des petites mol??cules : le renouveau d???une vieille id??e, Biologie Aujourd'hui, vol.209, issue.2, pp.145-159, 2015. ,
DOI : 10.1128/JVI.01410-12
Antiviral applications of Toll-like receptor agonists, Journal of Antimicrobial Chemotherapy, vol.67, issue.4, pp.789-801, 2012. ,
DOI : 10.1093/jac/dkr588
5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential, Journal of Biological Chemistry, vol.77, issue.47, pp.39776-3978810, 2012. ,
DOI : 10.1016/j.virol.2006.05.022
Species-specific detection of the antiviral small-molecule compound CMA by STING, The EMBO Journal, vol.7, issue.10, pp.1440-145086, 2013. ,
DOI : 10.1016/j.immuni.2008.09.003
Anticancer Flavonoids Are Mouse-Selective STING Agonists, ACS Chemical Biology, vol.8, issue.7, pp.1396-1401, 2013. ,
DOI : 10.1021/cb400264n
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid, The Journal of Immunology, vol.190, issue.10, pp.5216-522510, 2013. ,
DOI : 10.4049/jimmunol.1300097
Identification of human-selective analogues of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA), British Journal of Cancer, vol.6, issue.6, pp.1306-1315, 2013. ,
DOI : 10.1038/sj.bjc.6600479
Hydrolysis of 2???3???-cGAMP by ENPP1 and design of nonhydrolyzable analogs, Nature Chemical Biology, vol.10, issue.12, pp.1043-10481661, 2014. ,
DOI : 10.1359/jbmr.070714
An orally available, small-molecule interferon inhibits viral replication, Scientific Reports, vol.45, issue.1, pp.10-1038, 2012. ,
DOI : 10.1002/hep.21587
Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity, PLoS Pathogens, vol.8, issue.10, 2013. ,
DOI : 10.1371/journal.ppat.1003678.s014
URL : https://hal.archives-ouvertes.fr/pasteur-01113535
Quantitative Expression of Toll-Like Receptor 1-10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides, The Journal of Immunology, vol.168, issue.9, pp.4531-4537, 2002. ,
DOI : 10.4049/jimmunol.168.9.4531
Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State, Antimicrobial Agents and Chemotherapy, vol.60, issue.8, pp.282-298, 2016. ,
DOI : 10.1128/AAC.00282-16
Synergistic Suppression of Dengue Virus Replication Using a Combination of Nucleoside Analogs and Nucleoside Synthesis Inhibitors, Antimicrobial Agents and Chemotherapy, vol.59, issue.4, pp.2086-209304779, 1128. ,
DOI : 10.1128/AAC.04779-14
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification, Nature Chemical Biology, vol.4, issue.5, pp.361-3662050, 2016. ,
DOI : 10.1128/JVI.01151-10
STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1, Biochemical Journal, vol.13, issue.3, pp.511-524, 2015. ,
DOI : 10.1101/gad.1371305
Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification, Molecular and Cellular Biology, vol.30, issue.10, pp.2424-243601466, 1128. ,
DOI : 10.1128/MCB.01466-09
Ubiquitin in the activation and attenuation of innate antiviral immunity, The Journal of Experimental Medicine, vol.213, issue.1, pp.1-13, 2016. ,
DOI : 10.1038/ni.1979
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response, The Journal of Experimental Medicine, vol.209, issue.4, pp.661-66910, 2012. ,
DOI : 10.1038/ng.154
EHMT1 Protein Binds to Nuclear Factor-??B p50 and Represses Gene Expression, Journal of Biological Chemistry, vol.102, issue.37, pp.31207-31217, 2012. ,
DOI : 10.1038/emboj.2008.192
PubChem Substance and Compound databases, Nucleic Acids Research, vol.44, issue.D1, pp.1202-1213, 2016. ,
DOI : 10.1093/nar/gkv951
HitPick: a web server for hit identification and target prediction of chemical screenings, Bioinformatics, vol.29, issue.15, p.303, 1910. ,
DOI : 10.1093/bioinformatics/btt303
2561 | DOI:10.1038/s41598-017-02776-z 41 Exploration tools for drug discovery and beyond: applying SciFinder to interdisciplinary research, Curr Drug Discov Technol, vol.7, issue.2, pp.69-74, 2005. ,
Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents, Journal of Medicinal Chemistry, vol.52, issue.21, pp.6803-681310, 2009. ,
DOI : 10.1021/jm900697r
Inhibitory properties of 2-substituent-1H-benzimidazole-4-carboxamide derivatives against enteroviruses, Bioorganic & Medicinal Chemistry, vol.19, issue.8, pp.2641-2649, 2011. ,
DOI : 10.1016/j.bmc.2011.03.007
Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways, Trends in Immunology, vol.38, issue.3, pp.194-205, 2017. ,
DOI : 10.1016/j.it.2016.12.004
Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity, Cell, vol.141, issue.4, pp.668-681018, 2010. ,
DOI : 10.1016/j.cell.2010.04.018
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1), Journal of Biological Chemistry, vol.290, issue.19, pp.12184-12194, 2015. ,
DOI : 10.1001/jama.1986.03370220082029
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity, Immunity, vol.42, issue.2, pp.332-343012, 2015. ,
DOI : 10.1016/j.immuni.2015.01.012
Mitochondrial DNA stress primes the antiviral innate immune response, Nature, vol.34, issue.7548, pp.553-55710, 2015. ,
DOI : 10.1016/j.cell.2011.12.027
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays, Journal of Biomolecular Screening, vol.4, issue.2, pp.67-73, 1999. ,
DOI : 10.1177/108705719900400206