W. M. Schneider, M. D. Chevillotte, and C. M. Rice, Interferon-Stimulated Genes: A Complex Web of Host Defenses, Annual Review of Immunology, vol.32, issue.1, pp.513-54510, 2014.
DOI : 10.1146/annurev-immunol-032713-120231

J. M. Gonzalez-navajas, J. Lee, M. David, and E. Raz, Immunomodulatory functions of type I interferons, Nature Reviews Immunology, vol.170, pp.125-13510, 2012.
DOI : 10.4049/jimmunol.170.10.5195

E. Venereau, C. Ceriotti, and M. E. Bianchi, DAMPs from Cell Death to New Life, Front Immunol, vol.6, issue.422, p.422, 2015.

J. Wu and Z. J. Chen, Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids, Annual Review of Immunology, vol.32, issue.1, pp.461-48810, 2014.
DOI : 10.1146/annurev-immunol-032713-120156

A. Roers, B. Hiller, and V. Hornung, Recognition of Endogenous Nucleic Acids by the Innate Immune System, Immunity, vol.44, issue.4, pp.739-754002, 2016.
DOI : 10.1016/j.immuni.2016.04.002

G. R. Stark, J. E. Darnell, and . Jr, The JAK-STAT Pathway at Twenty, Immunity, vol.36, issue.4, pp.503-514, 2012.
DOI : 10.1016/j.immuni.2012.03.013

H. Cheon, E. C. Borden, and G. Stark, Interferons and Their Stimulated Genes in the Tumor Microenvironment, Seminars in Oncology, vol.41, issue.2, pp.156-173002, 2014.
DOI : 10.1053/j.seminoncol.2014.02.002

M. A. Lee-kirsch, C. Wolf, S. Kretschmer, and A. Roers, Type I interferonopathies???an expanding disease spectrum of immunodysregulation, Seminars in Immunopathology, vol.25, issue.4, pp.349-357, 2015.
DOI : 10.1016/j.coi.2012.11.004

Z. F. Tai, G. L. Zhang, and F. Wang, Identification of Small Molecule Activators of the Janus Kinase/Signal Transducer and Activator of Transcription Pathway Using a Cell-Based Screen, Biological & Pharmaceutical Bulletin, vol.35, issue.1, pp.65-71, 2012.
DOI : 10.1248/bpb.35.65

C. W. Lin, Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71, International Journal of Antimicrobial Agents, vol.32, issue.4, pp.355-359018, 2008.
DOI : 10.1016/j.ijantimicag.2008.04.018

R. Harvey, GSK983: A novel compound with broad-spectrum antiviral activity, Antiviral Research, vol.82, issue.1, pp.1-11015, 2008.
DOI : 10.1016/j.antiviral.2008.12.015

K. M. Bedard, Isoflavone Agonists of IRF-3 Dependent Signaling Have Antiviral Activity against RNA Viruses, Journal of Virology, vol.86, issue.13, pp.7334-734410, 2012.
DOI : 10.1128/JVI.06867-11

S. Pattabhi, ABSTRACT, Journal of Virology, vol.90, issue.5, pp.2372-238710, 2015.
DOI : 10.1128/JVI.02202-15

L. Martinez-gil, Identification of Small Molecules with Type I Interferon Inducing Properties by High-Throughput Screening, PLoS ONE, vol.31, issue.5, p.49049, 2012.
DOI : 10.1371/journal.pone.0049049.g006

D. A. Patel, A. C. Patel, W. C. Nolan, Y. Zhang, and M. J. Holtzman, High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery, PLoS ONE, vol.3, issue.5, 2012.
DOI : 10.1371/journal.pone.0036594.s002

F. Guo, RO 90-7501 Enhances TLR3 and RLR Agonist Induced Antiviral Response, PLoS ONE, vol.7, issue.10, 2012.
DOI : 10.1371/journal.pone.0042583.g009

D. Yan, Dual Myxovirus Screen Identifies a Small-Molecule Agonist of the Host Antiviral Response, Journal of Virology, vol.87, issue.20, pp.11076-1108710, 2013.
DOI : 10.1128/JVI.01425-13

T. M. Sali, Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses, PLOS Pathogens, vol.79, issue.12, 2015.
DOI : 10.1371/journal.ppat.1005324.s007

S. Es-saad, N. Tremblay, M. Baril, and D. Lamarre, Regulators of innate immunity as novel targets for panviral therapeutics, Current Opinion in Virology, vol.2, issue.5, pp.622-628, 2012.
DOI : 10.1016/j.coviro.2012.08.009

S. Khiar, N. Pietrancosta, and P. O. Vidalain, Stimuler la r??ponse interf??ron de type I avec des petites mol??cules : le renouveau d???une vieille id??e, Biologie Aujourd'hui, vol.209, issue.2, pp.145-159, 2015.
DOI : 10.1128/JVI.01410-12

N. J. Horscroft, D. C. Pryde, and H. Bright, Antiviral applications of Toll-like receptor agonists, Journal of Antimicrobial Chemotherapy, vol.67, issue.4, pp.789-801, 2012.
DOI : 10.1093/jac/dkr588

D. Prantner, 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential, Journal of Biological Chemistry, vol.77, issue.47, pp.39776-3978810, 2012.
DOI : 10.1016/j.virol.2006.05.022

T. Cavlar, T. Deimling, A. Ablasser, K. P. Hopfner, and V. Hornung, Species-specific detection of the antiviral small-molecule compound CMA by STING, The EMBO Journal, vol.7, issue.10, pp.1440-145086, 2013.
DOI : 10.1016/j.immuni.2008.09.003

S. Kim, Anticancer Flavonoids Are Mouse-Selective STING Agonists, ACS Chemical Biology, vol.8, issue.7, pp.1396-1401, 2013.
DOI : 10.1021/cb400264n

J. Conlon, Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid, The Journal of Immunology, vol.190, issue.10, pp.5216-522510, 2013.
DOI : 10.4049/jimmunol.1300097

S. M. Tijono, Identification of human-selective analogues of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA), British Journal of Cancer, vol.6, issue.6, pp.1306-1315, 2013.
DOI : 10.1038/sj.bjc.6600479

L. Li, Hydrolysis of 2???3???-cGAMP by ENPP1 and design of nonhydrolyzable analogs, Nature Chemical Biology, vol.10, issue.12, pp.1043-10481661, 2014.
DOI : 10.1359/jbmr.070714

H. Konishi, An orally available, small-molecule interferon inhibits viral replication, Scientific Reports, vol.45, issue.1, pp.10-1038, 2012.
DOI : 10.1002/hep.21587

M. Lucas-hourani, Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity, PLoS Pathogens, vol.8, issue.10, 2013.
DOI : 10.1371/journal.ppat.1003678.s014

URL : https://hal.archives-ouvertes.fr/pasteur-01113535

V. Hornung, Quantitative Expression of Toll-Like Receptor 1-10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides, The Journal of Immunology, vol.168, issue.9, pp.4531-4537, 2002.
DOI : 10.4049/jimmunol.168.9.4531

D. H. Chung, Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State, Antimicrobial Agents and Chemotherapy, vol.60, issue.8, pp.282-298, 2016.
DOI : 10.1128/AAC.00282-16

K. L. Yeo, Synergistic Suppression of Dengue Virus Replication Using a Combination of Nucleoside Analogs and Nucleoside Synthesis Inhibitors, Antimicrobial Agents and Chemotherapy, vol.59, issue.4, pp.2086-209304779, 1128.
DOI : 10.1128/AAC.04779-14

R. M. Deans, Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification, Nature Chemical Biology, vol.4, issue.5, pp.361-3662050, 2016.
DOI : 10.1128/JVI.01151-10

K. Blaszczyk, STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1, Biochemical Journal, vol.13, issue.3, pp.511-524, 2015.
DOI : 10.1101/gad.1371305

H. X. Shi, Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification, Molecular and Cellular Biology, vol.30, issue.10, pp.2424-243601466, 1128.
DOI : 10.1128/MCB.01466-09

S. M. Heaton, N. A. Borg, and V. M. Dixit, Ubiquitin in the activation and attenuation of innate antiviral immunity, The Journal of Experimental Medicine, vol.213, issue.1, pp.1-13, 2016.
DOI : 10.1038/ni.1979

T. C. Fang, Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response, The Journal of Experimental Medicine, vol.209, issue.4, pp.661-66910, 2012.
DOI : 10.1038/ng.154

C. K. Ea, S. Hao, K. S. Yeo, and D. Baltimore, EHMT1 Protein Binds to Nuclear Factor-??B p50 and Represses Gene Expression, Journal of Biological Chemistry, vol.102, issue.37, pp.31207-31217, 2012.
DOI : 10.1038/emboj.2008.192

S. Kim, PubChem Substance and Compound databases, Nucleic Acids Research, vol.44, issue.D1, pp.1202-1213, 2016.
DOI : 10.1093/nar/gkv951

X. Liu, I. Vogt, T. Haque, and M. Campillos, HitPick: a web server for hit identification and target prediction of chemical screenings, Bioinformatics, vol.29, issue.15, p.303, 1910.
DOI : 10.1093/bioinformatics/btt303

M. Haldeman, B. Vieira, F. Winer, and L. J. Knutsen, 2561 | DOI:10.1038/s41598-017-02776-z 41 Exploration tools for drug discovery and beyond: applying SciFinder to interdisciplinary research, Curr Drug Discov Technol, vol.7, issue.2, pp.69-74, 2005.

Y. Tong, Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents, Journal of Medicinal Chemistry, vol.52, issue.21, pp.6803-681310, 2009.
DOI : 10.1021/jm900697r

F. Xue, X. Luo, C. Ye, W. Ye, and Y. Wang, Inhibitory properties of 2-substituent-1H-benzimidazole-4-carboxamide derivatives against enteroviruses, Bioorganic & Medicinal Chemistry, vol.19, issue.8, pp.2641-2649, 2011.
DOI : 10.1016/j.bmc.2011.03.007

A. Zevini, D. Olagnier, and J. Hiscott, Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways, Trends in Immunology, vol.38, issue.3, pp.194-205, 2017.
DOI : 10.1016/j.it.2016.12.004

E. Dixit, Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity, Cell, vol.141, issue.4, pp.668-681018, 2010.
DOI : 10.1016/j.cell.2010.04.018

M. G. Kemp, L. A. Lindsey-boltz, and A. Sancar, UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1), Journal of Biological Chemistry, vol.290, issue.19, pp.12184-12194, 2015.
DOI : 10.1001/jama.1986.03370220082029

A. Hartlova, DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity, Immunity, vol.42, issue.2, pp.332-343012, 2015.
DOI : 10.1016/j.immuni.2015.01.012

A. P. West, Mitochondrial DNA stress primes the antiviral innate immune response, Nature, vol.34, issue.7548, pp.553-55710, 2015.
DOI : 10.1016/j.cell.2011.12.027

J. H. Zhang, T. D. Chung, and K. R. Oldenburg, A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays, Journal of Biomolecular Screening, vol.4, issue.2, pp.67-73, 1999.
DOI : 10.1177/108705719900400206