J. Stapleton, S. Foung, A. Muerhoff, J. Bukh, and P. Simmonds, The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae, Journal of General Virology, vol.92, issue.2, pp.233-279, 2011.
DOI : 10.1099/vir.0.027490-0

N. Tautz, B. Tews, and G. Meyers, The Molecular Biology of Pestiviruses Advances in virus research, pp.47-160, 2015.

I. Bintintan and G. Meyers, A new type of signal peptidase cleavage site identified in an RNA virus polyprotein . The Journal of biological chemistry, Epub, vol.285, issue.12, pp.8572-84, 2010.

T. Lackner, A. Müller, A. Pankraz, P. Becher, H. Thiel et al., Temporal Modulation of an Autoprotease Is Crucial for Replication and Pathogenicity of an RNA Virus, Journal of Virology, vol.78, issue.19, pp.10765-75, 2004.
DOI : 10.1128/JVI.78.19.10765-10775.2004

N. Tautz, A. Kaiser, and H. Thiel, NS3 Serine Protease of Bovine Viral Diarrhea Virus: Characterization of Active Site Residues, NS4A Cofactor Domain, and Protease???Cofactor Interactions, Virology, vol.273, issue.2, pp.351-63, 2000.
DOI : 10.1006/viro.2000.0425

J. Xu, E. Mendez, P. Caron, C. Lin, M. Murcko et al., Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication, J Virol, vol.71, issue.7, pp.5312-5334, 1997.

M. Wiskerchen and M. Collett, Pestivirus gene expression: Protein p80 of bovine viral diarrhea virus is a proteinase involved in polyprotein processing, Virology, vol.184, issue.1, pp.341-50, 1991.
DOI : 10.1016/0042-6822(91)90850-B

B. Lamp, C. Riedel, E. Wentz, M. Tortorici, and T. Rumenapf, Autocatalytic Cleavage within Classical Swine Fever Virus NS3 Leads to a Functional Separation of Protease and Helicase, Journal of Virology, vol.87, issue.21, pp.11872-83, 2013.
DOI : 10.1128/JVI.00754-13

J. Kim, K. Morgenstern, C. Lin, T. Fox, M. Dwyer et al., Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide, Cell, vol.87, issue.2, pp.343-55, 1996.
DOI : 10.1016/S0092-8674(00)81351-3

V. Brass, J. Berke, R. Montserret, H. Blum, F. Penin et al., Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex, Proceedings of the National Academy of Sciences, vol.289, issue.2, pp.14545-50, 2008.
DOI : 10.1006/jmbi.1999.2745

B. Lindenbach, B. Pragai, R. Montserret, R. Beran, A. Pyle et al., The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication, Journal of Virology, vol.81, issue.17, pp.8905-8923, 2007.
DOI : 10.1128/JVI.00937-07

T. Phan, A. Kohlway, P. Dimberu, A. Pyle, and B. Lindenbach, The Acidic Domain of Hepatitis C Virus NS4A Contributes to RNA Replication and Virus Particle Assembly, Journal of Virology, vol.85, issue.3, pp.1193-204, 2011.
DOI : 10.1128/JVI.01889-10

T. Lackner, H. Thiel, and N. Tautz, Dissection of a viral autoprotease elucidates a function of a cellular chaperone in proteolysis, Proceedings of the National Academy of Sciences, vol.166, issue.2, pp.1510-1515, 2006.
DOI : 10.1016/0003-2697(87)90587-2

A. Gallei, S. Blome, S. Gilgenbach, N. Tautz, V. Moennig et al., Cytopathogenicity of Classical Swine Fever Virus Correlates with Attenuation in the Natural Host, Journal of Virology, vol.82, issue.19, pp.9717-9746, 2008.
DOI : 10.1128/JVI.00782-08

P. Becher and N. Tautz, RNA recombination in pestiviruses: Cellular RNA sequences in viral genomes highlight the role of host factors for viral persistence and lethal disease, RNA Biology, vol.8, issue.2, pp.216-240, 2011.
DOI : 10.4161/rna.8.2.14514

J. Brownlie, M. Clarke, and C. Howard, Experimental production of fatal mucosal disease in cattle, Veterinary Record, vol.114, issue.22, pp.535-541, 1984.
DOI : 10.1136/vr.114.22.535

B. Kümmerer, N. Tautz, P. Becher, H. Thiel, and G. Meyers, The genetic basis for cytopathogenicity of pestiviruses, Veterinary Microbiology, vol.77, issue.1-2, pp.117-145, 2000.
DOI : 10.1016/S0378-1135(00)00268-6

B. Liess, S. Orban, H. Frey, G. Trautwein, W. Wiefel et al., Studies on transplacental transmissibility of a Bovine Virus Diarrhoea (BVD) vaccine virus in cattle1, Zentralblatt f??r Veterin??rmedizin Reihe B, vol.183, issue.1-10, pp.669-81, 1984.
DOI : 10.1080/01652176.1983.9693890

C. Jones, C. Murray, D. Eastman, J. Tassello, and C. Rice, Hepatitis C Virus p7 and NS2 Proteins Are Essential for Production of Infectious Virus, Journal of Virology, vol.81, issue.16, pp.8374-83, 2007.
DOI : 10.1128/JVI.00690-07

E. Lattwein, O. Klemens, S. Schwindt, P. Becher, and N. Tautz, Pestivirus Virion Morphogenesis in the Absence of Uncleaved Nonstructural Protein 2-3, Journal of Virology, vol.86, issue.1, pp.427-464, 2012.
DOI : 10.1128/JVI.06133-11

O. Klemens, D. Dubrau, and N. Tautz, ABSTRACT, Journal of Virology, vol.89, issue.22, p.26355097, 2015.
DOI : 10.1128/JVI.01646-15

M. Tortorici, S. Duquerroy, J. Kwok, C. Vonrhein, J. Perez et al., ABSTRACT, Journal of Virology, vol.89, issue.8, pp.4356-71, 2015.
DOI : 10.1128/JVI.03165-14

D. Luo, T. Xu, C. Hunke, G. Gruber, S. Vasudevan et al., Crystal Structure of the NS3 Protease-Helicase from Dengue Virus, Journal of Virology, vol.82, issue.1, pp.173-83, 2008.
DOI : 10.1128/JVI.01788-07

R. Assenberg, E. Mastrangelo, T. Walter, A. Verma, M. Milani et al., Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication, Journal of Virology, vol.83, issue.24, pp.12895-906, 2009.
DOI : 10.1128/JVI.00942-09

D. Luo, N. Wei, D. Doan, P. Paradkar, Y. Chong et al., Flexibility between the Protease and Helicase Domains of the Dengue Virus NS3 Protein Conferred by the Linker Region and Its Functional Implications, Journal of Biological Chemistry, vol.7, issue.24, pp.18817-18844, 2010.
DOI : 10.1016/0263-7855(96)00018-5

N. Yao, P. Reichert, S. Taremi, W. Prosise, and P. Weber, Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease???helicase, Structure, vol.7, issue.11, pp.1353-63, 1999.
DOI : 10.1016/S0969-2126(00)80025-8

K. Elbers, N. Tautz, P. Becher, T. Rümenapf, and H. Thiel, Processing in the Pestivirus E2-NS2 region: identification of the nonstructural proteins p7 and E2p7, J Virol, vol.70, issue.6, pp.4131-4136, 1996.

R. Love, H. Parge, J. Wickersham, Z. Hostomsky, N. Habuka et al., The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site, Cell, vol.87, issue.2, pp.331-373, 1996.
DOI : 10.1016/S0092-8674(00)81350-1

O. Isken, U. Langerwisch, V. Jirasko, D. Rehders, L. Redecke et al., A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication, PLoS pathogens, vol.11, issue.3, p.25774920, 2015.

A. Paredes and K. Blight, A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication, Journal of Virology, vol.82, issue.21, pp.10671-83, 2008.
DOI : 10.1128/JVI.00875-08

K. Blight, Allelic Variation in the Hepatitis C Virus NS4B Protein Dramatically Influences RNA Replication, Journal of Virology, vol.81, issue.11
DOI : 10.1128/JVI.02481-06

T. Dentzer, I. Lorenz, M. Evans, and C. Rice, Determinants of the Hepatitis C Virus Nonstructural Protein 2 Protease Domain Required for Production of Infectious Virus, Journal of Virology, vol.83, issue.24, pp.12702-12715, 2009.
DOI : 10.1128/JVI.01184-09

T. Phan, R. Beran, C. Peters, I. Lorenz, and B. Lindenbach, Hepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes, Journal of Virology, vol.83, issue.17, pp.891-900, 2009.
DOI : 10.1128/JVI.00891-09

M. Yi, Y. Ma, J. Yates, and S. Lemon, trans-Complementation of an NS2 Defect in a Late Step in Hepatitis C Virus (HCV) Particle Assembly and Maturation, PLoS Pathogens, vol.76, issue.5, 2009.
DOI : 10.1371/journal.ppat.1000403.t001

P. Evans, Scaling and assessment of data quality, Acta Crystallographica Section D Biological Crystallography, vol.62, issue.1, pp.72-82, 2005.
DOI : 10.1107/S0907444905036693

W. Corapi, R. Donis, and E. Dubovi, Characterization of a panel of monoclonal antibodies and their use in the study of the antigenic diversity of bovine viral diarrhea virus, Am J Vet Res, vol.51, issue.9, pp.1388-94, 1990.

E. Weiland, R. Stark, B. Haas, T. Rumenapf, G. Meyers et al., Pestivirus glycoprotein which induces neutralizing antibodies forms part of a disulfide-linked heterodimer, J Virol, vol.64, issue.8, pp.3563-3572, 1990.

L. Kasza, J. Shadduck, and G. Christofinis, Establishment, viral susceptibility and biological characteristics of a swine kidney cell line SK-6. Research in veterinary science, pp.46-51, 1972.

D. Schultz, M. Honda, L. Whetter, K. Mcknight, and S. Lemon, Mutations within the 5' nontranslated RNA of cell culture-adapted hepatitis A virus which enhance cap-independent translation in cultured African green monkey kidney cells, J Virol, vol.70, issue.2, pp.1041-1050, 1996.

W. Corapi, R. Donis, and E. Dubovi, Monoclonal antibody analyses of cytopathic and noncytopathic viruses from fatal bovine viral diarrhea virus infections, Journal of virology, vol.62, issue.8, pp.2823-2830, 1988.

G. Meyers, N. Tautz, P. Becher, H. Thiel, and B. Kümmerer, Recovery of cytopathogenic and noncytopathogenic bovine viral diarrhea viruses from cDNA constructs, J Virol, vol.70, issue.12, pp.8606-8619, 1996.

G. Sutter, M. Ohlmann, and V. Erfle, Non-replicating vaccinia vector efficiently expresses bacteriophage T7 RNA polymerase, FEBS Letters, vol.81, issue.1, pp.9-12, 1995.
DOI : 10.1016/S0022-2836(83)80282-4
URL : http://onlinelibrary.wiley.com/doi/10.1016/0014-5793(95)00843-X/pdf

A. Pankraz, H. Thiel, and P. Becher, Essential and Nonessential Elements in the 3' Nontranslated Region of Bovine Viral Diarrhea Virus, Journal of Virology, vol.79, issue.14, pp.9119-9146, 2005.
DOI : 10.1128/JVI.79.14.9119-9127.2005

G. Rinck, C. Birghan, T. Harada, G. Meyers, H. Thiel et al., A Cellular J-Domain Protein Modulates Polyprotein Processing and Cytopathogenicity of a Pestivirus, Journal of Virology, vol.75, issue.19, pp.9470-82, 2001.
DOI : 10.1128/JVI.75.19.9470-9482.2001

H. Schägger and G. Von-jagow, Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa, Analytical Biochemistry, vol.166, issue.2, pp.368-79, 1987.
DOI : 10.1016/0003-2697(87)90587-2

N. Tautz, T. Harada, A. Kaiser, G. Rinck, S. Behrens et al., Establishment and characterization of cytopathogenic and noncytopathogenic pestivirus replicons, J Virol, vol.73, issue.11, pp.9422-9454, 1999.