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Probabilistic Sequence Alignments: Realistic Models with Efficient Algorithms

Edouard Yeramian 1, * Edouard Debonneuil 1
* Corresponding author
Abstract : Alignment algorithms usually rely on simplified models of gaps for computational efficiency. Based on correspondences between alignments and structural models for nucleic acids, and using methods from statistical mechanics, we show that alignments with realistic laws for gaps can be computed with fast algorithms. Improved performances of probabilistic alignments with realistic models of gaps are illustrated. By contrast with optimization-based alignments, such improvements with realistic laws are not observed. General perspectives for biological and physical modelings are mentioned.
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Edouard Yeramian, Edouard Debonneuil. Probabilistic Sequence Alignments: Realistic Models with Efficient Algorithms. Physical Review Letters, American Physical Society, 2007, 98 (7), pp.078101. ⟨10.1103/PhysRevLett.98.078101⟩. ⟨pasteur-01570174⟩

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