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α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.

Abstract : Recent evidence suggests that disease progression in Parkinson's disease (PD) could occur by the spreading of α-synuclein (α-syn) aggregates between neurons. Here we studied the role of astrocytes in the intercellular transfer and fate of α-syn fibrils, using in vitro and ex vivo models. α-Syn fibrils can be transferred to neighboring cells; however, the transfer efficiency changes depending on the cell types. We found that α-syn is efficiently transferred from astrocytes to astrocytes and from neurons to astrocytes, but less efficiently from astrocytes to neurons. Interestingly, α-syn puncta are mainly found inside the lysosomal compartments of the recipient cells. However, differently from neurons, astrocytes are able to efficiently degrade fibrillar α-syn, suggesting an active role for these cells in clearing α-syn deposits. Astrocytes co-cultured with organotypic brain slices are able to take up α-syn fibrils from the slices. Altogether our data support a role for astrocytes in trapping and clearing α-syn pathological deposits in PD.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01568774
Contributor : Frida Loria <>
Submitted on : Thursday, July 27, 2017 - 12:11:26 PM
Last modification on : Friday, September 18, 2020 - 2:52:03 PM

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Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License

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Frida Loria, Jessica Y Vargas, Luc Bousset, Sylvie Syan, Audrey Salles, et al.. α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.. Acta Neuropathologica, Springer Verlag, 2017, pp.1-20. ⟨10.1007/s00401-017-1746-2⟩. ⟨pasteur-01568774⟩

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