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Journal Articles Acta Neuropathologica Year : 2017

α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.

Abstract

Recent evidence suggests that disease progression in Parkinson's disease (PD) could occur by the spreading of α-synuclein (α-syn) aggregates between neurons. Here we studied the role of astrocytes in the intercellular transfer and fate of α-syn fibrils, using in vitro and ex vivo models. α-Syn fibrils can be transferred to neighboring cells; however, the transfer efficiency changes depending on the cell types. We found that α-syn is efficiently transferred from astrocytes to astrocytes and from neurons to astrocytes, but less efficiently from astrocytes to neurons. Interestingly, α-syn puncta are mainly found inside the lysosomal compartments of the recipient cells. However, differently from neurons, astrocytes are able to efficiently degrade fibrillar α-syn, suggesting an active role for these cells in clearing α-syn deposits. Astrocytes co-cultured with organotypic brain slices are able to take up α-syn fibrils from the slices. Altogether our data support a role for astrocytes in trapping and clearing α-syn pathological deposits in PD.
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

pasteur-01568774 , version 1 (27-07-2017)

Licence

Attribution - NonCommercial - CC BY 4.0

Identifiers

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Frida Loria, Jessica y Vargas, Luc Bousset, Sylvie Syan, Audrey Salles, et al.. α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.. Acta Neuropathologica, 2017, pp.1-20. ⟨10.1007/s00401-017-1746-2⟩. ⟨pasteur-01568774⟩
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