Triangles bridge the scales: Quantifying cellular contributions to tissue deformation. - Archive ouverte HAL Access content directly
Journal Articles Physical Review E Year : 2017

Triangles bridge the scales: Quantifying cellular contributions to tissue deformation.

Abstract

In this article, we propose a general framework to study the dynamics and topology of cellular networks that capture the geometry of cell packings in two-dimensional tissues. Such epithelia undergo large-scale deformation during morphogenesis of a multicellular organism. Large-scale deformations emerge from many individual cellular events such as cell shape changes, cell rearrangements, cell divisions, and cell extrusions. Using a triangle-based representation of cellular network geometry, we obtain an exact decomposition of large-scale material deformation. Interestingly, our approach reveals contributions of correlations between cellular rotations and elongation as well as cellular growth and elongation to tissue deformation. Using this triangle method, we discuss tissue remodeling in the developing pupal wing of the fly Drosophila melanogaster.
Fichier principal
Vignette du fichier
PhysRevE.95.032401.pdf (3.81 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

pasteur-01545825 , version 1 (23-06-2017)

Identifiers

Cite

Matthias Merkel, Raphael Etournay, Marko Popović, Guillaume Salbreux, Suzanne Eaton, et al.. Triangles bridge the scales: Quantifying cellular contributions to tissue deformation.. Physical Review E , 2017, 95 (3), pp.032401. ⟨10.1103/PhysRevE.95.032401⟩. ⟨pasteur-01545825⟩
147 View
185 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More