Triangles bridge the scales: Quantifying cellular contributions to tissue deformation.

Matthias Merkel 1, 2, * Raphael Etournay 3, 4 Marko Popović 1 Guillaume Salbreux 5, 1 Suzanne Eaton 4 Frank Jülicher 1, *
* Auteur correspondant
1 MPI-PKS - Max Planck Institute for the Physics of Complex Systems
2 Syracuse University
3 Génétique et Physiologie de l'Audition
4 MPI-CBG - Max Planck Institute of Molecular Cell Biology and Genetics
5 The Francis Crick Institute
Abstract : In this article, we propose a general framework to study the dynamics and topology of cellular networks that capture the geometry of cell packings in two-dimensional tissues. Such epithelia undergo large-scale deformation during morphogenesis of a multicellular organism. Large-scale deformations emerge from many individual cellular events such as cell shape changes, cell rearrangements, cell divisions, and cell extrusions. Using a triangle-based representation of cellular network geometry, we obtain an exact decomposition of large-scale material deformation. Interestingly, our approach reveals contributions of correlations between cellular rotations and elongation as well as cellular growth and elongation to tissue deformation. Using this triangle method, we discuss tissue remodeling in the developing pupal wing of the fly Drosophila melanogaster.
Keywords : Shear deformation Viscoplasticity Viscoelasticity Strain Plasticity Plastic deformation Morphogenesis Biomechanics Elastic deformation
Type de document :
Article dans une revue
Physical Review E , American Physical Society (APS), 2017, 95 (3), pp.032401. 〈10.1103/PhysRevE.95.032401〉
Liste complète des métadonnées

Littérature citée [14 références]  Voir  Masquer  Télécharger
https://hal-pasteur.archives-ouvertes.fr/pasteur-01545825
Contributeur : Raphael Etournay <>
Soumis le : vendredi 23 juin 2017 - 12:49:43
Dernière modification le : vendredi 31 août 2018 - 09:09:07
Document(s) archivé(s) le : mercredi 10 janvier 2018 - 22:06:08

Fichier

PhysRevE.95.032401.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

PASTEUR | PSL | U1120 | UPMC

Citation

Matthias Merkel, Raphael Etournay, Marko Popović, Guillaume Salbreux, Suzanne Eaton, et al.. Triangles bridge the scales: Quantifying cellular contributions to tissue deformation.. Physical Review E , American Physical Society (APS), 2017, 95 (3), pp.032401. 〈10.1103/PhysRevE.95.032401〉. 〈pasteur-01545825〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

119

Téléchargements de fichiers

132