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A. We, W. Kasinrerk, C. Putthikhunt-for-anti-dengue-anti-domiii-mab, 2. J. Freire, and G. , Bowler for help and discussion; the staff at the crystallogenesis and chemogenomic & biological screening facilities at Institut Pasteur; the staff at beamlines PX1 and PX2 at SOLEIL synchrotron, the staff at beamlines ID23-1, ID23-2, ID29 and IB30B at the European Synchrotron Radiation Facility

F. Agou, I. Pasteur-for-the, M. A. Systemf, J. M. , and G. R. , We acknowledge support from the European Commission FP7 Programme for the DEN- FREE project under Grant Agreement number 282 378FP7S.); the 'Integrative Biology of Emerging Infectious Diseases' Labex (Laboratoire d'Excellence) grant number ANR-10-LABX-62-IBEID (French Government's 'Investissements d'Avenir' program ) (F.A.R.) the National Institute for Health Research Biomedical Research Centre, Funding Scheme, UK (G.R.S.); and the NEUTRAVIR grant from Région Ile-de-France (DIM-Maladies Infectieuses) (F.A.R.). G.R.S. is a Wellcome Trust Senior Investigator

F. A. Author, G. R. , J. M. Designed-the-experiments, P. G. , F. A. et al., designed the cysteine mutants; A.R. and A.S. produced and purified the recombinant DENV2-3-4 sE proteins and the antibody fragment A11W. produced antibodies and performed binding experiments, V. grew and optimized the crystals

M. V. , A. R. , P. G. , S. D. , A. S. Collected-synchrotron-data-;-m.-c et al., processed the data, built, refined and analysed the atomic modelsC. made the MALS experiments; G.B.S. did the floatation experiments with liposomes wrote the paper with the help of