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Characterization of nasal potential difference in cftr knockout and F508del-CFTR mice.

Résumé : BACKGROUND: Treatments designed to correct cystic fibrosis transmembrane conductance regulator (CFTR) defects must first be evaluated in preclinical experiments in the mouse model of cystic fibrosis (CF). Mice nasal mucosa mimics the bioelectric defect seen in humans. The use of nasal potential difference (V(TE)) to assess ionic transport is a powerful test evaluating the restoration of CFTR function. Nasal V(TE) in CF mice must be well characterized for correct interpretation.
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Submitted on : Wednesday, June 14, 2017 - 1:52:21 PM
Last modification on : Thursday, April 9, 2020 - 11:55:02 AM

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Emilie Lyne Saussereau, Delphine Roussel, Siradiou Diallo, Laurent Debarbieux, Aleksander Edelman, et al.. Characterization of nasal potential difference in cftr knockout and F508del-CFTR mice.. PLoS ONE, Public Library of Science, 2013, 8 (3), pp.e57317. ⟨10.1371/journal.pone.0057317⟩. ⟨pasteur-01539086⟩

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