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The Lysis of Pathogenic Escherichia coli by Bacteriophages Releases Less Endotoxin Than by β-Lactams.

Résumé : Other than numerous experimental data assessing phage therapy efficacy, questions regarding safety of this approach are not sufficiently addressed. In particular, as phages can kill bacterial cells within <10 minutes, the associated endotoxin release (ER) in severe infections caused by gram-negative bacteria could be a matter of concern.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01539007
Contributor : Laurent Debarbieux <>
Submitted on : Wednesday, June 14, 2017 - 11:54:40 AM
Last modification on : Wednesday, August 19, 2020 - 11:18:15 AM

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Nicolas Dufour, Raphaëlle Delattre, Jean-Damien Ricard, Laurent Debarbieux. The Lysis of Pathogenic Escherichia coli by Bacteriophages Releases Less Endotoxin Than by β-Lactams.. Clinical Infectious Diseases, Oxford University Press (OUP), 2017, 64 (11), pp.1582-1588. ⟨10.1093/cid/cix184⟩. ⟨pasteur-01539007⟩

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