Protozoan Parasites and Type I IFNs.

Sasha Silva-Barrios (1) , Simona Stäger (1)

1 INRS-IAF - Institut Armand Frappier

For many years, the role of interferon (IFN)-I has been characterized primarily in the context of viral infections. However, regulatory functions mediated by IFN-I have also been described against bacterial infections and in tumor immunology. Only recently, the interest in understanding the immune functions mediated by IFN-I has dramatically increased in the field of protozoan infections. In this review, we discuss the discrete role of IFN-I in the immune response against major protozoan infections: Plasmodium, Leishmania, Trypanosoma, and Toxoplasma.

Keywords: IFN-I; Leishmania; Plasmodium; Toxoplasma; Trypanosoma; protozoan infections

Domains: Life Sciences [q-bio]; Parasitology

Sasha Silva-Barrios, Simona Stäger. Protozoan Parasites and Type I IFNs.. Frontiers in Immunology, 2017, 8, pp.Article 14. ⟨10.3389/fimmu.2017.00014⟩. ⟨pasteur-01533834⟩