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A. We, M. Cournac, L. Marbouty, and . Lazar, ERC grant agreement 260822), from Agence Nationale pour la Recherche (MeioRec ANR-13-BSV6-0012-02), and from ERASynBio and ANR (IESY ANR-14-SYNB-0001-03). H.M. and V.S are partly supported by Pasteur-Roux Fellowships. J.D. was funded by National Science Foundation of China (31471254), Tsinghua University Initiative Scientific Research Program (2011Z02296), Ph.D. Programs Foundation of Ministry of Education of China (20110002120055) and Chinese Ministry of Science and Technology (2012CB725201). Y.J.Y. was supported by Natural Science Foundation of China 21621004 and 21390203. Y.C. was funded by a Chancellor's Fellowship from the University of Edinburgh, a startup fund from SULSA and BBSRC grants This research was supported to Y.S. by the research grant from the Shenzhen Engineering Laboratory for Clinical Molecular Diagnostic Promotion (JZF No This work was supported in part by funding from the United States National Science Foundation [grant MCB-0718846 and MCB-1026068 to, This research was supported by funding to R.K. from the European Research Council under the 7th Framework Program MCB-0546446 and MCB-1445545 to J.S.B.]. J.D.B. and J.S.B. are founders and directors of Neochromosome, Inc. J.D.B. serves as a scientific advisor to Recombinetics, 2007.

I. Sample6, These arrangements are reviewed and managed by the committees on Conflict of interest at NYU Langone Medical

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L. A. Mitchell, Synthesis, debugging and effects of synthetic chromosome consolidation: synVI and beyond (This issue)