Candida albicans is not always the preferential yeast colonizing humans: a study in Wayampi Amerindians.

Cécile Angebault 1, 2, 3, 4 Félix Djossou 5 Sophie Abélanet 4 Emmanuelle Permal 4 Mouna Ben Soltana 1 Laure Diancourt 6 Christiane Bouchier 7 Paul-Louis Woerther 3 François Catzeflis 8 Antoine Andremont 3 Christophe D'Enfert 4 Marie-Elisabeth Bougnoux 2, 4, 1, *
* Auteur correspondant
1 CHU Necker - Enfants Malades [AP-HP]
2 UPD5 - Université Paris Descartes - Paris 5
3 Laboratoire de bactériologie
4 Biologie et Pathogénicité fongiques
5 Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyanne Française]
6 PF8 - Génotypage des Pathogènes et Santé Publique (Plate-forme)
7 Génomique (Plate-Forme)
8 ISEM - Institut des Sciences de l'Evolution de Montpellier
Abstract : In industrialized countries Candida albicans is considered the predominant commensal yeast of the human intestine, with approximately 40% prevalence in healthy adults. We discovered a highly original colonization pattern that challenges this current perception by studying in a 4- year interval a cohort of 151 Amerindians living in a remote community (French Guiana), and animals from their environment. The prevalence of C. albicans was persistently low (3% and 7% of yeast carriers). By contrast, Candida krusei and Saccharomyces cerevisiae were detected in over 30% of carriers. We showed that C. krusei and S. cerevisiae carriage was of food or environmental origin, whereas C. albicans carriage was associated with specific risk factors (being female and living in a crowded household). We also showed using whole-genome sequence comparison that C. albicans strains can persist in the intestinal tract of a healthy individual over a 4-year period.
Keywords : candida albicans intestinal colonization whole-genome sequencing yeasts amerindians MLST
Type de document :
Article dans une revue
Journal of Infectious Diseases, Oxford University Press (OUP), 2013, 208 (10), pp.1705-16. 〈10.1093/infdis/jit389〉
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Cécile Angebault, Félix Djossou, Sophie Abélanet, Emmanuelle Permal, Mouna Ben Soltana, et al.. Candida albicans is not always the preferential yeast colonizing humans: a study in Wayampi Amerindians.. Journal of Infectious Diseases, Oxford University Press (OUP), 2013, 208 (10), pp.1705-16. 〈10.1093/infdis/jit389〉. 〈pasteur-01522841〉

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