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Candida albicans is not always the preferential yeast colonizing humans: a study in Wayampi Amerindians.

Abstract : In industrialized countries Candida albicans is considered the predominant commensal yeast of the human intestine, with approximately 40% prevalence in healthy adults. We discovered a highly original colonization pattern that challenges this current perception by studying in a 4- year interval a cohort of 151 Amerindians living in a remote community (French Guiana), and animals from their environment. The prevalence of C. albicans was persistently low (3% and 7% of yeast carriers). By contrast, Candida krusei and Saccharomyces cerevisiae were detected in over 30% of carriers. We showed that C. krusei and S. cerevisiae carriage was of food or environmental origin, whereas C. albicans carriage was associated with specific risk factors (being female and living in a crowded household). We also showed using whole-genome sequence comparison that C. albicans strains can persist in the intestinal tract of a healthy individual over a 4-year period.
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Cécile Angebault, Félix Djossou, Sophie Abélanet, Emmanuelle Permal, Mouna Ben Soltana, et al.. Candida albicans is not always the preferential yeast colonizing humans: a study in Wayampi Amerindians.. Journal of Infectious Diseases, Oxford University Press (OUP), 2013, 208 (10), pp.1705-16. ⟨10.1093/infdis/jit389⟩. ⟨pasteur-01522841⟩

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