Genetic diversity among Candida albicans isolates associated with vertical transmission in preterm triplets.

Gautier Hoarau (1) , Marie-Elisabeth Bougnoux (2, 3) , Antoine Fily (4, 1) , Nadine François (1) , Séverine Loridant (1) , Samir Jawhara (1) , Christophe d'Enfert (3) , Daniel Poulain (1) , Boualem Sendid (1)

1 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]
2 Unité de Parasitologie-Mycologie, Service de Microbiologie [Hôpital Necker-Enfants-Malades, Paris]
3 BPF - Biologie et Pathogénicité fongiques
4 Service de Médecine Néonatale

We report a case of congenital candidiasis in triplets, in the context of premature labor at 25 weeks gestation, without symptomatic vaginitis or chorioamnionitis. All three infants died as a result of prematurity, aggravated by systemic candidiasis. Multi-locus sequence typing confirmed vertical transmission of Candida albicans from the mother to the triplets and revealed a slight diversity among the strains isolated from the neonates.

Keywords: Candida albicans; Vertical transmission; Multi-locus sequence typing; Congenital candidiasis

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Microbiology and Parasitology; Mycology

Gautier Hoarau, Marie-Elisabeth Bougnoux, Antoine Fily, Nadine François, Séverine Loridant, et al.. Genetic diversity among Candida albicans isolates associated with vertical transmission in preterm triplets.. Mycopathologia, 2014, 178 (3-4), pp.285-90. ⟨10.1007/s11046-014-9803-z⟩. ⟨pasteur-01518493⟩