Cytosolically expressed PrP GPI-signal peptide interacts with mitochondria.

Abstract : We previously reported that PrP GPI-anchor signal peptide (GPI-SP) is specifically degraded by the proteasome. Additionally, we showed that the point mutation P238S, responsible for a genetic form of prion diseases, while not affecting the GPI-anchoring process, results in the accumulation of PrP GPI-SP, suggesting the possibility that PrP GPI-anchor signal peptide could play a role in neurodegenerative prion diseases. We now show that PrP GPI-SP, when expressed as a cytosolic peptide, is able to localize to the mitochondria and to induce mitochondrial fragmentation and vacuolarization, followed by loss in mitochondrial membrane potential, ultimately resulting in apoptosis. Our results identify the GPI-SP of PrP as a novel candidate responsible for the impairment in mitochondrial function involved in the synaptic pathology observed in prion diseases, establishing a link between PrP GPI-SP accumulation and neuronal death.
Type de document :
Article dans une revue
Communicative and Integrative Biology, Taylor & Francis Open, 2015, 8 (3), pp.e1036206. 〈10.1177/44.12.8985128〉
Liste complète des métadonnées

Littérature citée [37 références]  Voir  Masquer  Télécharger

https://hal-pasteur.archives-ouvertes.fr/pasteur-01511552
Contributeur : Reine Bouyssie <>
Soumis le : vendredi 21 avril 2017 - 11:11:04
Dernière modification le : mardi 25 avril 2017 - 01:05:28
Document(s) archivé(s) le : samedi 22 juillet 2017 - 12:44:11

Fichier

Cytosolically expressed PrP GP...
Publication financée par une institution

Licence


Distributed under a Creative Commons Paternité - Pas d'utilisation commerciale 4.0 International License

Identifiants

Collections

Citation

Gianni Guizzunti, Chiara Zurzolo. Cytosolically expressed PrP GPI-signal peptide interacts with mitochondria.. Communicative and Integrative Biology, Taylor & Francis Open, 2015, 8 (3), pp.e1036206. 〈10.1177/44.12.8985128〉. 〈pasteur-01511552〉

Partager

Métriques

Consultations de la notice

90

Téléchargements de fichiers

127