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S. E. Acknowledgements, was supported by a stipend from the Pasteur -Paris University (PPU) International PhD Program; A.C.S.P. was supported by a PTR grant (PTR374) Running costs were supported by Institut Pasteur, PasteurInnov (PIV15-197), PTR grant (PTR451), CNRS, Fondation Recherche Médicale (FRM DBS20140930771) Funding for the LTQ-Orbitrap Velos acquisition was secured through a DIM Malinf grant from the region Ile