C. Manca, L. Tsenova, S. Freeman, A. K. Barczak, M. Tovey et al., W/Beijing Strains Upregulate Type I IFNs and Increase Expression of Negative Regulators of the Jak-Stat Pathway, Journal of Interferon & Cytokine Research, vol.25, issue.11, pp.694-701, 2005.
DOI : 10.1089/jir.2005.25.694

F. Mcnab, K. Mayer-barber, A. Sher, A. Wack, O. Garra et al., Type I interferons in infectious disease, Nature Reviews Immunology, vol.119, issue.2, pp.87-103, 2015.
DOI : 10.1016/j.immuni.2012.01.011

D. A. Muruve, V. Pé-trilli, A. K. Zaiss, L. R. White, S. A. Clark et al., The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response, Nature, vol.440, issue.7183, pp.103-107, 2008.
DOI : 10.1038/nature06664

A. Novikov, M. Cardone, R. Thompson, K. Shenderov, K. D. Kirschman et al., Mycobacterium tuberculosis Triggers Host Type I IFN Signaling To Regulate IL-1?? Production in Human Macrophages, The Journal of Immunology, vol.187, issue.5, pp.2540-2547, 2011.
DOI : 10.4049/jimmunol.1100926

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159798

D. Ordway, M. Henao-tamayo, M. Harton, G. Palanisamy, J. Troudt et al., The Hypervirulent Mycobacterium tuberculosis Strain HN878 Induces a Potent TH1 Response followed by Rapid Down-Regulation, The Journal of Immunology, vol.179, issue.1, pp.522-531, 2007.
DOI : 10.4049/jimmunol.179.1.522

I. M. Orme, R. T. Robinson, C. , and A. M. , The balance between protective and pathogenic immune responses in the TB-infected lung, Nature Immunology, vol.162, issue.1, pp.57-63, 2015.
DOI : 10.1038/ni.2474

T. H. Ottenhoff and S. H. Kaufmann, Vaccines against tuberculosis: Where are we and where do we need to go? PLoS Pathog, 2012.
DOI : 10.1371/journal.ppat.1002607

URL : http://doi.org/10.1371/journal.ppat.1002607

A. S. Pym, P. Brodin, R. Brosch, M. Huerre, C. et al., Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti, Molecular Microbiology, vol.232, issue.Suppl., pp.709-717, 2002.
DOI : 10.1046/j.1365-2958.2002.03237.x

L. Ramakrishnan, N. A. Federspiel, and S. Falkow, Granuloma-Specific Expression of Mycobacterium Virulence Proteins from the Glycine-Rich PE-PGRS Family, Science, vol.288, issue.5470, pp.1436-1439, 2000.
DOI : 10.1126/science.288.5470.1436

A. Romagnoli, M. P. Etna, E. Giacomini, M. Pardini, M. E. Remoli et al., in human dendritic cells, Autophagy, vol.169, issue.9, pp.1357-1370, 2012.
DOI : 10.4161/auto.5.5.8823

A. A. Ryan, J. K. Nambiar, T. M. Wozniak, B. Roediger, E. Shklovskaya et al., Antigen Load Governs the Differential Priming of CD8 T Cells in Response to the Bacille Calmette Guerin Vaccine or Mycobacterium tuberculosis Infection, The Journal of Immunology, vol.182, issue.11, pp.7172-7177, 2009.
DOI : 10.4049/jimmunol.0801694

P. Sagoo, Z. Garcia, B. Breart, F. Lema^-itre, D. Michonneau et al., In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity, Nature Medicine, vol.415, issue.1, pp.64-71, 2016.
DOI : 10.1126/science.8066449

URL : https://hal.archives-ouvertes.fr/pasteur-01253201

F. Sayes, L. Sun, D. Luca, M. Simeone, R. Degaiffier et al., Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII 2764 secretion: Encoded PE-PPE proteins predicts vaccine potential, Cell Reports Cell Host Microbe, vol.18, issue.11, pp.2752-2765, 2012.

F. Sayes, A. Pawlik, W. Frigui, M. I. Grö-schel, S. Crommelynck et al., CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection, PLOS Pathogens, vol.28, issue.11, 2016.
DOI : 10.1371/journal.ppat.1005770.s009

URL : http://doi.org/10.1371/journal.ppat.1005770

R. Simeone, A. Bobard, J. Lippmann, W. Bitter, L. Majlessi et al., Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death, PLoS Pathogens, vol.203, issue.2, 2012.
DOI : 10.1371/journal.ppat.1002507.s009

URL : http://doi.org/10.1371/journal.ppat.1002507

R. Simeone, F. Sayes, O. Song, M. I. Grö-schel, P. Brodin et al., Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo, PLOS Pathogens, vol.25, issue.2, 2015.
DOI : 10.1371/journal.ppat.1004650.s007

R. Simeone, L. Majlessi, J. Enninga, and R. Brosch, Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access, Cellular Microbiology, vol.153, issue.8, pp.1070-1077, 2016.
DOI : 10.1111/cmi.12606

F. Spertini, R. Audran, R. Chakour, O. Karoui, V. Steiner-monard et al., Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial, The Lancet Respiratory Medicine, vol.3, issue.12, pp.953-962, 2015.
DOI : 10.1016/S2213-2600(15)00435-X

L. M. Stamm, J. H. Morisaki, L. Y. Gao, R. L. Jeng, K. L. Mcdonald et al., Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility, 2003.
DOI : 10.1084/jem.20031072

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194249

S. A. Stanley, J. E. Johndrow, P. Manzanillo, and J. S. Cox, The Type I IFN Response to Infection with Mycobacterium tuberculosis Requires ESX-1-Mediated Secretion and Contributes to Pathogenesis, The Journal of Immunology, vol.178, issue.5, pp.3143-3152, 2007.
DOI : 10.4049/jimmunol.178.5.3143

L. Sula, . Radkovsky´, and I. Radkovsky´radkovsky´, Protective effects of M. microti vaccine against tuberculosis, J. Hyg. Epidemiol. Microbiol. Immunol, vol.20, pp.1-6, 1976.

M. Uplekar, D. Weil, K. Lonnroth, E. Jaramillo, C. Lienhardt et al., WHO's new End TB Strategy, The Lancet, vol.385, issue.9979, pp.1799-1801, 2015.
DOI : 10.1016/S0140-6736(15)60570-0

N. Van-der-wel, D. Hava, D. Houben, D. Fluitsma, M. Van-zon et al., M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid Cells, Cell, vol.129, issue.7, pp.1287-1298, 2007.
DOI : 10.1016/j.cell.2007.05.059

J. Wang, F. Mcintosh, N. Radomski, K. Dewar, R. Simeone et al., Insights on the Emergence of Mycobacterium tuberculosis from the Analysis of Mycobacterium kansasii, Genome Biology and Evolution, vol.7, issue.3, pp.856-870, 2015.
DOI : 10.1093/gbe/evv035

URL : https://hal.archives-ouvertes.fr/pasteur-01352692

R. Wassermann, M. F. Gulen, C. Sala, S. G. Perin, Y. Lou et al., Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1, Cell Host & Microbe, vol.17, issue.6, pp.799-810, 2015.
DOI : 10.1016/j.chom.2015.05.003

URL : http://dx.doi.org/10.1016/j.chom.2015.05.003

R. O. Watson, P. S. Manzanillo, and J. S. Cox, Extracellular M.??tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway, Cell, vol.150, issue.4, pp.803-815, 2012.
DOI : 10.1016/j.cell.2012.06.040

R. O. Watson, S. L. Bell, D. A. Macduff, J. M. Kimmey, E. J. Diner et al., The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy, Cell Host & Microbe, vol.17, issue.6, pp.811-819, 2015.
DOI : 10.1016/j.chom.2015.05.004

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466081

K. E. Wiens, E. , and J. D. , The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent, PLOS Pathogens, vol.355, issue.3, 2016.
DOI : 10.1371/journal.ppat.1005809.s004

K. W. Wong, W. R. Jacobs, and . Jr, Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis, Cellular Microbiology, vol.2, issue.9, pp.1371-1384, 2011.
DOI : 10.1111/j.1462-5822.2011.01625.x

J. S. Woodworth, S. M. Fortune, and S. M. Behar, Bacterial Protein Secretion Is Required for Priming of CD8+ T Cells Specific for the Mycobacterium tuberculosis Antigen CFP10, Infection and Immunity, vol.76, issue.9, pp.4199-4205, 2008.
DOI : 10.1128/IAI.00307-08

L. Zhang, H. W. Ru, F. Z. Chen, C. Y. Jin, R. F. Sun et al., Variable Virulence and Efficacy of BCG Vaccine Strains in Mice and Correlation With Genome Polymorphisms, Molecular Therapy, vol.24, issue.2, pp.398-405, 2016.
DOI : 10.1038/mt.2015.216

F. C. Bange, F. M. Collins, W. R. Jacobs, and . Jr, Survival of mice infected with Mycobacterium smegmatis containing large DNA fragments from Mycobacterium tuberculosis, Tubercle and Lung Disease, vol.79, issue.3, pp.171-180, 1999.
DOI : 10.1054/tuld.1998.0201

M. K. Chaveroche, J. M. Ghigo, and C. Enfert, A rapid method for efficient gene replacement in the filamentous fungus Aspergillus nidulans, Nucleic Acids Research, vol.28, issue.22, p.97, 2000.
DOI : 10.1093/nar/28.22.e97

W. Frigui, D. Bottai, L. Majlessi, M. Monot, E. Josselin et al., Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP, PLoS Pathogens, vol.74, issue.2, p.33, 2008.
DOI : 10.1371/journal.ppat.0040033.st002

URL : https://hal.archives-ouvertes.fr/pasteur-01370872

L. Majlessi, M. Simsova, Z. Jarvis, P. Brodin, M. J. Rojas et al., An Increase in Antimycobacterial Th1-Cell Responses by Prime-Boost Protocols of Immunization Does Not Enhance Protection against Tuberculosis, Infection and Immunity, vol.74, issue.4, pp.2128-2137, 2006.
DOI : 10.1128/IAI.74.4.2128-2137.2006

F. Sayes, L. Sun, D. Luca, M. Simeone, R. Degaiffier et al., Strong Immunogenicity and Cross-Reactivity of Mycobacterium tuberculosis ESX-5 Type VII Secretion -Encoded PE-PPE Proteins Predicts Vaccine Potential, Cell Host & Microbe, vol.11, issue.4, pp.352-363, 2012.
DOI : 10.1016/j.chom.2012.03.003

URL : https://hal.archives-ouvertes.fr/pasteur-01104794

R. Simeone, F. Sayes, O. Song, M. I. Groschel, P. Brodin et al., Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo, PLOS Pathogens, vol.25, issue.2, 2015.
DOI : 10.1371/journal.ppat.1004650.s007

T. P. Stinear, T. Seemann, P. F. Harrison, G. A. Jenkin, J. K. Davies et al., Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis, Genome Research, vol.18, issue.5, pp.729-741, 2008.
DOI : 10.1101/gr.075069.107