Pressure reversal of general anaesthetics: A possible mechanism from molecular dynamics simulations - Archive ouverte HAL Access content directly
Journal Articles Journal of Molecular Liquids Year : 2009

Pressure reversal of general anaesthetics: A possible mechanism from molecular dynamics simulations

(1) , (2, 3) , (4) , (4)
1
2
3
4

Abstract

In this work, we performed computer simulations of halothane embedded in a fully hydrated dimyristoylphosphatidylcholine (DMPC) membrane. Since the action of general anaesthetics was known to be pressure dependent, we carried out the simulations performed under physiological conditions and also at elevated pressures (i.e., 2 × 10 7 Pa and 4 × 10 7 Pa). The results clearly show that at high pressures the halothane molecules tend to cluster together. Based on these results, we propose a possible mechanism for the pressure reversal of anaesthesia.
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

pasteur-01502151 , version 1 (05-04-2017)

Identifiers

Cite

P. Chau, P. Jedlovszky, P.N.M. Hoang, S. Picaud. Pressure reversal of general anaesthetics: A possible mechanism from molecular dynamics simulations. Journal of Molecular Liquids, 2009, 147 (1-2), pp.128 - 134. ⟨10.1016/j.molliq.2008.09.005⟩. ⟨pasteur-01502151⟩
36 View
3 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More