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. Heinz, Langmead and Salzberg, 2012) with standard settings, removing reads that could not be uniquely mapped Indexed and sorted bam files were parsed to HOMER 2010) for further analysis. Tag directories were generated for each sample with removal of duplicate reads (-tbp 1 option) BedGraph files displaying normalized counts (reads per million) were generated for direct visualization in the UCSC Genome Browser (https://genome.ucsc.edu/) using the makeUCSCfile HOMER script. H3K4Me2 enriched regions were identified using HOMER findPeaks with -region -size 1000 -minDist 2500 options. Overlapping and non-overlapping regions between two samples were identified using the intersect function of BEDTools (Quinlan and Hall, 2010) or the HOMER mergePeaks script (-d given option) requiring a minimal overlap of 1bp, Reads were demultiplexed using BaseSpace (Illumina) and aligned to the mouse genome (mm10 build) using Bowtie Sets of cell typespecific H3K4Me2+ regions were visualized as heatmaps with Java TreeView

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. Miltenyi, IL-12, IL-18, IL-25, IL-33, IL-1?, IL-23 (20 ng/ml each, R&D) were provided in various combinations as indicated. For bulk culture, fresh cytokines and medium were 37, p.37

N. Dr, JMS (Hôpital Bichat) N/A Human Intestine Dr