Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus. - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue Cellular Microbiology Année : 2016

Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus.

Christine Henry
  • Fonction : Auteur
Thierry Fontaine
Christoph Heddergott
  • Fonction : Auteur
Pauline Robinet
  • Fonction : Auteur
  • PersonId : 763180
  • IdRef : 155698230
Vishukumar Aimanianda
Remi Beau
  • Fonction : Auteur
Anne Beauvais
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Isabelle Mouyna
Arnaud Fekkar
Jean-Paul Latgé
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  • PersonId : 835028

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Résumé

The galactomannan is a major cell wall molecule of Aspergillus fumigatus. This molecule is composed of a linear mannan with a repeating unit composed of four α1,6 and α1,2 linked mannose with side chains of galactofuran. To obtain a better understanding of the mannan biosynthesis in A. fumigatus, it was decided to undertake the successive deletion of the 11 genes which are putative orthologs of the mannosyltransferases responsible for establishing α1,6 and α1,2 mannose linkages in yeast. These deletions did not lead to a reduction of the mannan content of the cell wall of the mycelium of A. fumigatus. In contrast, the mannan content of the conidial cell wall was reduced and this reduction was associated with a partial disorganization of the cell wall leading to defects in conidial survival both in vitro and in vivo.

Dates et versions

pasteur-01500709 , version 1 (03-04-2017)

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Citer

Christine Henry, Thierry Fontaine, Christoph Heddergott, Pauline Robinet, Vishukumar Aimanianda, et al.. Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus.. Cellular Microbiology, 2016, 18 (12), pp.1881-1891. ⟨10.1111/cmi.12665⟩. ⟨pasteur-01500709⟩
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