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Journal articles
Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus.
Christine Henry
1
Thierry Fontaine
1
Christoph Heddergott
1
Pauline Robinet
1
Vishukumar Aimanianda
1
Remi Beau
1
Anne Beauvais
1
Isabelle Mouyna
1
Marie-Christine Prevost
2
Arnaud Fekkar
3
Yanan Zhao
4
David Perlin
4
Jean-Paul Latgé
1, *
Christine Henry 1
Author
Thierry Fontaine 1
Author IdHAL : thierryfontaine ORCID : https://orcid.org/0000-0002-8184-789X
Christoph Heddergott 1
Author
Pauline Robinet 1
Author
Vishukumar Aimanianda 1
Author IdHAL : vishukumar-aimanianda
Remi Beau 1
Author
Anne Beauvais 1
Author
Isabelle Mouyna 1
Author IdHAL : mouyna-isabelle
Jean-Paul Latgé 1
Correspondent author
1
Aspergillus (Département de Mycologie - 25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
2
CITECH - Microscopie ultrastructurale - Ultrapole (Département Biologie cellulaire et Infection, CITECH, 25-28 rue du Docteur Roux - 75724 Paris cedex 15 - )
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
3
Service de parasitologie - mycologie [CHU Pitié-Salpétrière] (47-83, boulevard de l'Hôpital 75013 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
- Sorbonne Université (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
4
RU - Rutgers, The State University of New Jersey [New Brunswick] (57 US Highway 1, New Brunswick, NJ 08901-8554 - United States)
- Rutgers - Rutgers University System (Camden, Newark, New Brunswick, New Jersey - United States)
Abstract : The galactomannan is a major cell wall molecule of Aspergillus fumigatus. This molecule is composed of a linear mannan with a repeating unit composed of four α1,6 and α1,2 linked mannose with side chains of galactofuran. To obtain a better understanding of the mannan biosynthesis in A. fumigatus, it was decided to undertake the successive deletion of the 11 genes which are putative orthologs of the mannosyltransferases responsible for establishing α1,6 and α1,2 mannose linkages in yeast. These deletions did not lead to a reduction of the mannan content of the cell wall of the mycelium of A. fumigatus. In contrast, the mannan content of the conidial cell wall was reduced and this reduction was associated with a partial disorganization of the cell wall leading to defects in conidial survival both in vitro and in vivo.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01500709
Contributor : Vishukumar Aimanianda <>
Submitted on : Monday, April 3, 2017 - 3:49:30 PM
Last modification on : Tuesday, August 3, 2021 - 7:02:02 PM
Contributor : Vishukumar Aimanianda <>
Submitted on : Monday, April 3, 2017 - 3:49:30 PM
Last modification on : Tuesday, August 3, 2021 - 7:02:02 PM
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- HAL Id : pasteur-01500709, version 1
- DOI : 10.1111/cmi.12665
- PUBMED : 27603677
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Christine Henry, Thierry Fontaine, Christoph Heddergott, Pauline Robinet, Vishukumar Aimanianda, et al.. Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus.. Cellular Microbiology, Wiley, 2016, 18 (12), pp.1881-1891. ⟨10.1111/cmi.12665⟩. ⟨pasteur-01500709⟩
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