Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus. - Archive ouverte HAL Access content directly
Journal Articles Cellular Microbiology Year : 2016

Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus.

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Christine Henry
  • Function : Author
Thierry Fontaine
Christoph Heddergott
  • Function : Author
Pauline Robinet
  • Function : Author
  • PersonId : 763180
  • IdRef : 155698230
Vishukumar Aimanianda
Remi Beau
  • Function : Author
Anne Beauvais
  • Function : Author
Isabelle Mouyna
Jean-Paul Latgé
  • Function : Correspondent author
  • PersonId : 835028

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Abstract

The galactomannan is a major cell wall molecule of Aspergillus fumigatus. This molecule is composed of a linear mannan with a repeating unit composed of four α1,6 and α1,2 linked mannose with side chains of galactofuran. To obtain a better understanding of the mannan biosynthesis in A. fumigatus, it was decided to undertake the successive deletion of the 11 genes which are putative orthologs of the mannosyltransferases responsible for establishing α1,6 and α1,2 mannose linkages in yeast. These deletions did not lead to a reduction of the mannan content of the cell wall of the mycelium of A. fumigatus. In contrast, the mannan content of the conidial cell wall was reduced and this reduction was associated with a partial disorganization of the cell wall leading to defects in conidial survival both in vitro and in vivo.

Dates and versions

pasteur-01500709 , version 1 (03-04-2017)

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Christine Henry, Thierry Fontaine, Christoph Heddergott, Pauline Robinet, Vishukumar Aimanianda, et al.. Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus.. Cellular Microbiology, 2016, 18 (12), pp.1881-1891. ⟨10.1111/cmi.12665⟩. ⟨pasteur-01500709⟩
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