Abstract : Given the tremendous complexity of brain organisation, here I propose a strategy that dynamically links stages of brain organisation from genes to consciousness, at four privileged structural levels: genes; transcription factors (TFs)-gene networks; synaptic epigenesis; and long-range connectivity. These structures are viewed as nested and reciprocally inter-regulated, with a hierarchical organisation that proceeds on different timescales during the course of evolution and development. Interlevel bridging mechanisms include intrinsic variation-selection mechanisms, which offer a community of bottom-up and top-down models linking genes to consciousness in a stepwise manner.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01476038
Contributeur : Anne Lassailly-Bondaz
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Soumis le : vendredi 24 février 2017 - 15:01:05
Dernière modification le : jeudi 11 janvier 2018 - 06:28:10
Document(s) archivé(s) le : jeudi 25 mai 2017 - 12:56:33
Jean-Pierre Changeux. Climbing Brain Levels of Organisation from Genes to Consciousness.. Trends in Cognitive Sciences, Elsevier, 2017, xx, 〈10.1016/j.tics.2017.01.004〉. 〈pasteur-01476038〉