Abstract : Given the tremendous complexity of brain organisation, here I propose a strategy that dynamically links stages of brain organisation from genes to consciousness, at four privileged structural levels: genes; transcription factors (TFs)-gene networks; synaptic epigenesis; and long-range connectivity. These structures are viewed as nested and reciprocally inter-regulated, with a hierarchical organisation that proceeds on different timescales during the course of evolution and development. Interlevel bridging mechanisms include intrinsic variation-selection mechanisms, which offer a community of bottom-up and top-down models linking genes to consciousness in a stepwise manner.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01476038 Contributor : Anne Lassailly-BondazConnect in order to contact the contributor Submitted on : Friday, February 24, 2017 - 3:01:05 PM Last modification on : Thursday, April 7, 2022 - 10:10:32 AM Long-term archiving on: : Thursday, May 25, 2017 - 12:56:33 PM
Jean-Pierre Changeux. Climbing Brain Levels of Organisation from Genes to Consciousness.. Trends in Cognitive Sciences, Elsevier, 2017, xx, ⟨10.1016/j.tics.2017.01.004⟩. ⟨pasteur-01476038⟩