Genetics of auditory mechano-electrical transduction.

Abstract : The hair bundles of cochlear hair cells play a central role in the auditory mechano-electrical transduction (MET) process. The identification of MET components and of associated molecular complexes by biochemical approaches is impeded by the very small number of hair cells within the cochlea. In contrast, human and mouse genetics have proven to be particularly powerful. The study of inherited forms of deafness led to the discovery of several essential proteins of the MET machinery, which are currently used as entry points to decipher the associated molecular networks. Notably, MET relies not only on the MET machinery but also on several elements ensuring the proper sound-induced oscillation of the hair bundle or the ionic environment necessary to drive the MET current. Here, we review the most significant advances in the molecular bases of the MET process that emerged from the genetics of hearing.
Type de document :
Article dans une revue
Pflügers Archiv European Journal of Physiology, Springer Verlag (Germany), 2015, 467 (1), pp.49-72. 〈10.1007/s00424-014-1552-9〉
Liste complète des métadonnées

https://hal-pasteur.archives-ouvertes.fr/pasteur-01472836
Contributeur : Nicolas Michalski <>
Soumis le : mardi 21 février 2017 - 13:05:06
Dernière modification le : vendredi 31 août 2018 - 09:13:20
Document(s) archivé(s) le : lundi 22 mai 2017 - 15:21:00

Fichier

art_10.1007_s00424-014-1552-9....
Publication financée par une institution

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Nicolas Michalski, Christine Petit. Genetics of auditory mechano-electrical transduction.. Pflügers Archiv European Journal of Physiology, Springer Verlag (Germany), 2015, 467 (1), pp.49-72. 〈10.1007/s00424-014-1552-9〉. 〈pasteur-01472836〉

Partager

Métriques

Consultations de la notice

466

Téléchargements de fichiers

192