RAG1 and RAG2 Form a Stable Postcleavage Synaptic Complex with DNA Containing Signal Ends in V(D)J Recombination, Cell, vol.89, issue.1, pp.43-53, 1997. ,
DOI : 10.1016/S0092-8674(00)80181-6
Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways, Nucleic Acids Research, vol.38, issue.9, pp.2944-2954, 2010. ,
DOI : 10.1093/nar/gkp1252
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation, Cell, vol.80, issue.5, pp.813-823, 1995. ,
DOI : 10.1016/0092-8674(95)90360-7
V(D)J Recombination in Ku86-Deficient Mice: Distinct Effects on Coding, Signal, and Hybrid Joint Formation, Immunity, vol.7, issue.1, pp.37-47, 1997. ,
DOI : 10.1016/S1074-7613(00)80508-7
Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation, Proc. Natl. Acad. Sci. USA 95, pp.15559-15564, 1998. ,
DOI : 10.1073/pnas.95.26.15559
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination, Nature, vol.194, issue.7101, pp.466-470, 2006. ,
DOI : 10.1038/nature04866
The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis, Cellular and Molecular Life Sciences (CMLS), vol.54, issue.8, pp.880-891, 1998. ,
DOI : 10.1007/s000180050216
Rag mutations reveal robust alternative end joining, Nature, vol.55, issue.7161, pp.483-486, 2007. ,
DOI : 10.1038/nature06168
Analysis of regions of RAG-2 important for V(D)J recombination, Nucleic Acids Research, vol.22, issue.10, pp.1810-1814, 1994. ,
DOI : 10.1093/nar/22.10.1810
Roles for NBS1 in Alternative Nonhomologous End-Joining of V(D)J Recombination Intermediates, Molecular Cell, vol.34, issue.1, pp.13-25, 2009. ,
DOI : 10.1016/j.molcel.2009.03.009
The RAG2 C terminus suppresses genomic instability and lymphomagenesis, Nature, vol.101, issue.7336, pp.119-123, 2011. ,
DOI : 10.1038/nature09755
URL : https://hal.archives-ouvertes.fr/pasteur-01471708
Expanding the proteome: disordered and alternatively folded proteins, Quarterly Reviews of Biophysics, vol.78, issue.04, pp.467-518, 2011. ,
DOI : 10.1016/j.bbrc.2009.02.151
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189428
A practical overview of protein disorder prediction methods, Proteins: Structure, Function, and Bioinformatics, vol.101, issue.Pt 3, pp.1-14, 2006. ,
DOI : 10.1002/prot.21075
Fuzziness: linking regulation to protein dynamics, Mol. BioSyst., vol.399, issue.6734, pp.168-177, 2012. ,
DOI : 10.1039/C1MB05234A
URL : http://hdl.handle.net/2437/124519
Dynamic protein???DNA recognition: beyond what can be seen, Trends in Biochemical Sciences, vol.36, issue.8, pp.415-423, 2011. ,
DOI : 10.1016/j.tibs.2011.04.006
Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination, Proc. Natl. Acad. Sci. USA, pp.22487-22492, 2010. ,
DOI : 10.1073/pnas.1014958107
The Response to and Repair of RAG-Mediated DNA Double-Strand Breaks, Annual Review of Immunology, vol.30, issue.1, pp.175-202, 2012. ,
DOI : 10.1146/annurev-immunol-030409-101320
Assembly of a 12/23 Paired Signal Complex: A Critical Control Point in V(D)J Recombination, Molecular Cell, vol.1, issue.7, pp.1011-1019, 1998. ,
DOI : 10.1016/S1097-2765(00)80101-X
The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci, Cell, vol.141, issue.3, pp.419-431, 2010. ,
DOI : 10.1016/j.cell.2010.03.010
Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends, Proc. Natl. Acad, 2001. ,
DOI : 10.1073/pnas.221471198
The roles of the RAG1 and RAG2 ''noncore'' regions in V(D)J recombination and lymphocyte development, 2009. ,
Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination, Genes & Development, vol.13, issue.23, pp.3059-3069, 1999. ,
DOI : 10.1101/gad.13.23.3059
RAG Proteins Shepherd Double-Strand Breaks to a Specific Pathway, Suppressing Error-Prone Repair, but RAG Nicking Initiates Homologous Recombination, Cell, vol.117, issue.2, pp.171-184, 2004. ,
DOI : 10.1016/S0092-8674(04)00301-0
URL : http://doi.org/10.1016/s0092-8674(04)00301-0
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination, Cell, vol.83, issue.7, pp.1079-1089, 1995. ,
DOI : 10.1016/0092-8674(95)90135-3
A Conserved Degradation Signal Regulates RAG-2 Accumulation during Cell Division and Links V(D)J Recombination to the Cell Cycle, Immunity, vol.5, issue.6, pp.575-589, 1996. ,
DOI : 10.1016/S1074-7613(00)80272-1
Retroviral DNA integration: reaction pathway and critical intermediates, The EMBO Journal, vol.65, issue.6, pp.1295-1304, 2006. ,
DOI : 10.1016/S0960-894X(03)00059-3
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422164
The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism, Cell, vol.54, issue.4, pp.453-460, 1988. ,
DOI : 10.1016/0092-8674(88)90066-9
Improved sequence-based prediction of disordered regions with multilayer fusion of multiple information sources, Bioinformatics, vol.26, issue.18, pp.489-496, 2010. ,
DOI : 10.1093/bioinformatics/btq373
Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.711, issue.1-2, pp.61-72, 2011. ,
DOI : 10.1016/j.mrfmmm.2011.02.005
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination, Science, vol.248, issue.4962, pp.1517-1523, 1990. ,
DOI : 10.1126/science.2360047
Comparative architecture of transposase and integrase complexes, Nature Structural Biology, vol.8, issue.4, pp.302-307, 2001. ,
DOI : 10.1038/86166
Models for antigen receptor gene rearrangement: CDR3 length, Immunology and Cell Biology, vol.13, issue.4, pp.323-332, 2007. ,
DOI : 10.1006/smim.1994.1019
Definition of a core region of RAG-2 that is functional in V(D)J recombination, Nucleic Acids Research, vol.22, issue.10, pp.1805-1809, 1994. ,
DOI : 10.1093/nar/22.10.1805
V(D)J Recombination: Mechanisms of Initiation, Annual Review of Genetics, vol.45, issue.1, pp.167-202, 2011. ,
DOI : 10.1146/annurev-genet-110410-132552
H3K4me3 Stimulates the V(D)J RAG Complex for Both Nicking and Hairpinning in trans in Addition to Tethering in cis: Implications for Translocations, Molecular Cell, vol.34, issue.5, pp.535-544, 2009. ,
DOI : 10.1016/j.molcel.2009.05.011
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4???ligase IV during chromosomal translocation formation, Nature Structural & Molecular Biology, vol.5, issue.4, pp.410-416, 2010. ,
DOI : 10.1038/nsmb.1773
DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation, PLoS Genetics, vol.140, issue.6, 2011. ,
DOI : 10.1371/journal.pgen.1002080.s007
URL : https://hal.archives-ouvertes.fr/inserm-00715279
Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination, The Journal of Experimental Medicine, vol.159, issue.7, pp.1717-1727, 2007. ,
DOI : 10.4049/jimmunol.171.8.4062
URL : https://hal.archives-ouvertes.fr/hal-00167659
Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes, Science, vol.337, issue.6090, pp.64-69, 2012. ,
DOI : 10.1126/science.1219240
Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination, Genes & Development, vol.16, issue.15, pp.1934-1949, 2002. ,
DOI : 10.1101/gad.984502
Intrinsically disordered regions as affinity tuners in protein???DNA interactions, Mol. BioSyst., vol.108, issue.1, pp.47-57, 2012. ,
DOI : 10.1039/C1MB05273J
A Direct Interaction between the RAG2 C Terminus and the Core Histones Is Required for Efficient V(D)J Recombination, Immunity, vol.23, issue.2, pp.203-212, 2005. ,
DOI : 10.1016/j.immuni.2005.07.004
The endless tale of non-homologous end-joining, Cell Research, vol.163, issue.1, pp.114-124, 2008. ,
DOI : 10.1093/nar/gkm579
IgH class switching and translocations use a robust non-classical end-joining pathway, Nature, vol.4, issue.7161, pp.478-482, 2007. ,
DOI : 10.1038/nature06020
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination, The Journal of Experimental Medicine, vol.96, issue.12, pp.2625-2639, 2009. ,
DOI : 10.1101/gad.10.19.2411
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806628
rearrangement and gene amplification, The Journal of Experimental Medicine, vol.96, issue.7, pp.1369-1380, 2010. ,
DOI : 10.1073/pnas.79.9.3015
Coupling of V(D)J Recombination to the Cell Cycle Suppresses Genomic Instability and Lymphoid Tumorigenesis, Immunity, vol.34, issue.2, pp.163-174, 2011. ,
DOI : 10.1016/j.immuni.2011.02.003
Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations, Cell, vol.109, issue.7, pp.811-821, 2002. ,
DOI : 10.1016/S0092-8674(02)00770-5