RAG1 and RAG2 Form a Stable Postcleavage Synaptic Complex with DNA Containing Signal Ends in V(D)J Recombination, Cell, vol.89, issue.1, pp.43-53, 1997. ,
DOI : 10.1016/S0092-8674(00)80181-6
Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition, BMC Molecular Biology, vol.8, issue.1, p.29, 2007. ,
DOI : 10.1186/1471-2199-8-29
XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining, Cell, vol.124, issue.2, pp.301-314, 2006. ,
DOI : 10.1016/j.cell.2005.12.031
URL : http://doi.org/10.1016/j.cell.2005.12.031
Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases ?? and ?? for nonhomologous end joining in human whole-cell extracts, Nucleic Acids Research, vol.37, issue.12, pp.4055-62, 2009. ,
DOI : 10.1093/nar/gkp283
Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System, Cell, vol.152, issue.3, pp.417-446, 2013. ,
DOI : 10.1016/j.cell.2013.01.007
Crystal Structure of Human XLF: A Twist in Nonhomologous DNA End-Joining, Molecular Cell, vol.28, issue.6, pp.1093-101, 2007. ,
DOI : 10.1016/j.molcel.2007.10.024
A human XRCC4-XLF complex bridges DNA, Nucleic Acids Research, vol.40, issue.4, pp.1868-78, 2012. ,
DOI : 10.1093/nar/gks022
URL : http://doi.org/10.1093/nar/gks022
Prokaryotic Homologs of the Eukaryotic DNA-End-Binding Protein Ku, Novel Domains in the Ku Protein and Prediction of a Prokaryotic Double-Strand Break Repair System, Genome Research, vol.11, issue.8, 2001. ,
DOI : 10.1101/gr.181001
Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice, Current Biology, vol.8, issue.25, pp.1395-98, 1998. ,
DOI : 10.1016/S0960-9822(98)00021-9
DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining, Nucleic Acids Research, vol.32, issue.17, pp.5249-59, 2004. ,
DOI : 10.1093/nar/gkh842
URL : http://doi.org/10.1093/nar/gkh842
Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities, Genes, Chromosomes and Cancer, vol.27, issue.4, pp.310-331, 2009. ,
DOI : 10.1002/gcc.20641
Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins, EMBO J, vol.8, pp.735-777, 1989. ,
Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks, Adv. Immunol, vol.116, pp.1-49, 2012. ,
DOI : 10.1016/B978-0-12-394300-2.00001-6
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70, Proc. Natl, 2010. ,
DOI : 10.1093/emboj/17.8.2404
Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1), Proc. Natl. Acad. Sci. USA, pp.2473-78, 2012. ,
DOI : 10.1038/nature04866
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4, The Journal of Experimental Medicine, vol.15, issue.2, pp.417-444, 2010. ,
DOI : 10.1016/S0092-8674(02)00770-5
Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation, Proc. Natl. Acad. Sci. USA 95, pp.15559-645, 1998. ,
DOI : 10.1016/S1074-7613(00)80618-4
V(D)J Recombination in Ku86-Deficient Mice: Distinct Effects on Coding, Signal, and Hybrid Joint Formation, Immunity, vol.7, issue.1, pp.37-47, 1997. ,
DOI : 10.1016/S1074-7613(00)80508-7
Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1, Molecular Cell, vol.42, issue.3, pp.319-348, 2011. ,
DOI : 10.1016/j.molcel.2011.03.019
URL : http://doi.org/10.1016/j.molcel.2011.03.019
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination, The Journal of Experimental Medicine, vol.207, issue.4, pp.855-65, 2010. ,
DOI : 10.1016/j.cell.2008.08.037
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856023
Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways, pp.5093-103, 1996. ,
Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4, Mutation Research/DNA Repair, vol.433, issue.1, pp.53-58, 1999. ,
DOI : 10.1016/S0921-8777(98)00063-9
Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly, Cell, vol.124, issue.2, pp.260-62, 2006. ,
DOI : 10.1016/j.cell.2005.12.030
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks, Cell, vol.141, issue.2, pp.243-54, 2010. ,
DOI : 10.1016/j.cell.2010.03.012
Eukaryotic DNA Polymerases: Proposal for a Revised Nomenclature, Journal of Biological Chemistry, vol.276, issue.47, pp.43487-90, 2001. ,
DOI : 10.1074/jbc.R100056200
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting, Nucleic Acids Research, vol.39, issue.12, p.82, 2011. ,
DOI : 10.1093/nar/gkr218
RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection, Molecular Cell, vol.49, issue.5, pp.858-71, 2013. ,
DOI : 10.1016/j.molcel.2013.01.002
Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining, The EMBO Journal, vol.21, issue.11, pp.2827-2859, 2002. ,
DOI : 10.1093/emboj/21.11.2827
An end-joining repair mechanism in Escherichia coli, Proc. Natl. Acad. Sci. USA, pp.2141-2187, 2010. ,
DOI : 10.1038/ncb1623
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836643
Response to RAG-Mediated V(D)J Cleavage by NBS1 and gamma-H2AX, Science, vol.290, issue.5498, pp.1962-65, 2000. ,
DOI : 10.1126/science.290.5498.1962
The DNA Damage Response: Making It Safe to Play with Knives, Molecular Cell, vol.40, issue.2, pp.179-204, 2010. ,
DOI : 10.1016/j.molcel.2010.09.019
Rag mutations reveal robust alternative end joining, Nature, vol.55, issue.7161, pp.483-86, 2007. ,
DOI : 10.1038/nature06168
Functions and regulation of human artemis in double strand break repair, Journal of Cellular Biochemistry, vol.24, issue.6, pp.1346-51, 2007. ,
DOI : 10.1002/jcb.21226
Human Rad50/Mre11 Is a Flexible Complex that Can Tether DNA Ends, Molecular Cell, vol.8, issue.5, pp.1129-1164, 2001. ,
DOI : 10.1016/S1097-2765(01)00381-1
The RAG2 C terminus suppresses genomic instability and lymphomagenesis, Nature, vol.101, issue.7336, pp.119-142, 2011. ,
DOI : 10.1038/nature09755
URL : https://hal.archives-ouvertes.fr/pasteur-01471708
Roles for NBS1 in Alternative Nonhomologous End-Joining of V(D)J Recombination Intermediates, Molecular Cell, vol.34, issue.1, pp.13-25, 2009. ,
DOI : 10.1016/j.molcel.2009.03.009
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation, Nature, vol.404, issue.6777, pp.510-524, 2000. ,
DOI : 10.1038/35006670
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721590
53BP1 facilitates long-range DNA end-joining during V(D)J recombination, Nature, vol.442, issue.7221, pp.529-562, 2008. ,
DOI : 10.1038/nature07476
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596817
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility, Nature, vol.151, issue.7221, pp.524-552, 2008. ,
DOI : 10.1038/nature07433
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613650
Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching, Science, vol.22, issue.2, pp.711-726, 2013. ,
DOI : 10.1128/MCB.22.2.555-566.2002
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation, DNA Repair, vol.9, issue.12, pp.1307-1321, 2010. ,
DOI : 10.1016/j.dnarep.2010.09.019
A means to a DNA end: the many roles of Ku, Nature Reviews Molecular Cell Biology, vol.5, issue.5, pp.367-78, 2004. ,
DOI : 10.1038/nrm1367
Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences, Adv. Immunol, vol.86, pp.43-112, 2005. ,
DOI : 10.1016/S0065-2776(04)86002-4
Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells, Nucleic Acids Research, vol.33, issue.18, pp.5978-90, 2005. ,
DOI : 10.1093/nar/gki912
A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice, Molecular Cell, vol.49, issue.5, pp.872-83, 2013. ,
DOI : 10.1016/j.molcel.2013.01.001
Chromothripsis and cancer: causes and consequences of chromosome shattering, Nature Reviews Cancer, vol.131, issue.10, pp.663-70, 2012. ,
DOI : 10.1038/nrc3352
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV, Nature, vol.396, pp.173-77, 1998. ,
Transient Stability of DNA Ends Allows Nonhomologous End Joining to Precede Homologous Recombination, Molecular Cell, vol.10, issue.5, pp.1189-99, 2002. ,
DOI : 10.1016/S1097-2765(02)00705-0
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development, Nature, vol.404, issue.6780, pp.897-900, 2000. ,
DOI : 10.1038/35009138
A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis, Cell, vol.95, issue.7, pp.891-902, 1998. ,
DOI : 10.1016/S0092-8674(00)81714-6
Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination, Cell Cycle, vol.102, issue.12, pp.1928-1963, 2011. ,
DOI : 10.1016/j.molcel.2011.02.015
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154416
Mechanisms that Promote and Suppress Chromosomal Translocations in Lymphocytes, Annual Review of Immunology, vol.29, issue.1, pp.319-50, 2011. ,
DOI : 10.1146/annurev-immunol-031210-101329
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells, Nature, vol.388, pp.492-95, 1997. ,
APLF promotes the assembly and activity of non-homologous end joining protein complexes, The EMBO Journal, vol.14, issue.1, pp.112-137, 2013. ,
DOI : 10.1093/nar/gks622
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps, The EMBO Journal, vol.26, issue.14, pp.1010-1033, 2007. ,
DOI : 10.1038/sj.emboj.7601729
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852838
Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends, Proc. Natl. Acad. Sci. USA, pp.20902-20909, 2007. ,
DOI : 10.1093/nar/gkf452
PARP1-dependent Kinetics of Recruitment of MRE11 and NBS1 Proteins to Multiple DNA Damage Sites, Journal of Biological Chemistry, vol.283, issue.2, pp.1197-208, 2008. ,
DOI : 10.1074/jbc.M706734200
The Response to and Repair of RAG-Mediated DNA Double-Strand Breaks, Annual Review of Immunology, vol.30, issue.1, pp.175-202, 2012. ,
DOI : 10.1146/annurev-immunol-030409-101320
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes, Nature, vol.37, issue.7329, pp.245-294, 2011. ,
DOI : 10.1038/nature09585
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150591
A Stable RAG1???RAG2???DNA Complex That Is Active in V(D)J Cleavage, Cell, vol.88, issue.1, pp.65-72, 1997. ,
DOI : 10.1016/S0092-8674(00)81859-0
CDK targets Sae2 to control DNA-end resection and homologous recombination, Nature, vol.24, issue.7213, pp.689-92, 2008. ,
DOI : 10.1038/nature07215
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635538
Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair, Journal of Biological Chemistry, vol.284, issue.14, pp.9558-65, 2009. ,
DOI : 10.1074/jbc.M808906200
Double-strand break repair in Ku86- and XRCC4-deficient cells, Nucleic Acids Research, vol.26, issue.23, pp.5333-5375, 1998. ,
DOI : 10.1093/nar/26.23.5333
URL : http://doi.org/10.1093/nar/26.23.5333
Collaboration and competition between DNA double-strand break repair pathways, FEBS Letters, vol.39, issue.17, pp.3703-3711, 2010. ,
DOI : 10.1016/j.febslet.2010.07.057
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954739
The power of DNA double-strand break (DSB) repair testing to predict breast cancer susceptibility, The FASEB Journal, vol.26, issue.5, pp.2094-104, 2012. ,
DOI : 10.1096/fj.11-200790
Advances in using PARP inhibitors to treat cancer, BMC Medicine, vol.10, issue.Suppl 15, p.255, 2012. ,
DOI : 10.4161/cc.10.8.15273
Functions and Regulation of Artemis: A Goddess in the Maintenance of Genome Integrity, Journal of Radiation Research, vol.51, issue.5, pp.503-512, 2010. ,
DOI : 10.1269/jrr.10017
RAG Proteins Shepherd Double-Strand Breaks to a Specific Pathway, Suppressing Error-Prone Repair, but RAG Nicking Initiates Homologous Recombination, Cell, vol.117, issue.2, pp.171-84, 2004. ,
DOI : 10.1016/S0092-8674(04)00301-0
URL : http://doi.org/10.1016/s0092-8674(04)00301-0
Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex, Science, vol.304, issue.5667, pp.93-96, 2004. ,
DOI : 10.1126/science.1091496
CtIP promotes microhomology-mediated alternative end joining during class-switch recombination, Nature Structural & Molecular Biology, vol.1765, issue.1, pp.75-79, 2011. ,
DOI : 10.1038/nature01574
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471154
Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination, Molecular Cell, vol.31, issue.5, pp.631-671, 2008. ,
DOI : 10.1016/j.molcel.2008.07.017
URL : http://doi.org/10.1016/j.molcel.2008.07.017
Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA, pp.14405-14416, 1996. ,
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway, Annual Review of Biochemistry, vol.79, issue.1, pp.181-211, 2010. ,
DOI : 10.1146/annurev.biochem.052308.093131
Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development, Proc. Natl. Acad. Sci. USA, pp.3903-3911, 2012. ,
DOI : 10.1084/jem.20100285
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309750
Human cancers express mutator phenotypes: origin, consequences and targeting, Nature Reviews Cancer, vol.7, issue.6, pp.450-57, 2011. ,
DOI : 10.1038/nrc3063
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007007
Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination, Cell, vol.108, issue.6, pp.781-94, 2002. ,
DOI : 10.1016/S0092-8674(02)00671-2
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining, Biochemical Journal, vol.417, issue.3, pp.639-50, 2009. ,
DOI : 10.1042/BJ20080413
Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in RecA and RecB-independent DNA end-joining at regions of microhomology, DNA Repair, vol.6, issue.10, pp.1413-1437, 2007. ,
DOI : 10.1016/j.dnarep.2007.04.004
The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism, Cell, vol.54, issue.4, pp.453-60, 1988. ,
DOI : 10.1016/0092-8674(88)90066-9
The stability of broken ends of chromosomes in Zea mays, Genetics, vol.26, pp.234-82, 1941. ,
A Streamlined Method for Detecting Structural Variants in Cancer Genomes by Short Read Paired-End Sequencing, PLoS ONE, vol.12, issue.10, p.48314, 2012. ,
DOI : 10.1371/journal.pone.0048314.s001
URL : https://hal.archives-ouvertes.fr/pasteur-01471706
The impact of translocations and gene fusions on cancer causation, Nature Reviews Cancer, vol.3, issue.4, pp.233-278, 2007. ,
DOI : 10.1038/nrc2091
Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency, Cell, vol.105, issue.2, pp.177-86, 2001. ,
DOI : 10.1016/S0092-8674(01)00309-9
Choosing the right path: Does DNA-PK help make the decision?, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.711, issue.1-2, pp.73-86, 2011. ,
DOI : 10.1016/j.mrfmmm.2011.02.010
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109507
A minute chromosome in human chronic granulocytic leukemia, Science, vol.132, pp.1497-501, 1960. ,
DOI : 10.1007/bf01630378
Requirement for Ku80 in growth and immunoglobulin V(D)J recombination, Nature, vol.382, issue.6591, pp.551-55, 1996. ,
DOI : 10.1038/382551a0
A Backup DNA Repair Pathway Moves to the Forefront, Cell, vol.131, issue.2, pp.223-248, 2007. ,
DOI : 10.1016/j.cell.2007.10.005
Origin of Chromosomal Translocations in Lymphoid Cancer, Cell, vol.141, issue.1, pp.27-38, 2010. ,
DOI : 10.1016/j.cell.2010.03.016
Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair, Proc. Natl. Acad. Sci. USA, pp.2455-605, 2012. ,
DOI : 10.1016/S1097-2765(00)80264-6
Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining, Proc. Natl. Acad. Sci. USA, pp.2234-2273, 2013. ,
DOI : 10.1073/pnas.1121470109
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection, Nature Methods, vol.132, issue.9, pp.765-70, 2011. ,
DOI : 10.1038/nbt1409
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases, Nature Biotechnology, vol.73, issue.7, pp.808-824, 2008. ,
DOI : 10.1038/nbt1410
Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair, The Journal of Cell Biology, vol.3, issue.5, pp.705-725, 2011. ,
DOI : 10.1126/science.1083430
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171114
Characteristics of ??-H2AX foci at DNA double-strand breaks sites, Biochemistry and Cell Biology, vol.81, issue.3, pp.123-152, 2003. ,
DOI : 10.1139/o03-042
Paradigm switching in the germinal center, Nature Immunology, vol.5, issue.5, pp.476-77, 2004. ,
DOI : 10.1038/ni0504-476
Ku80 removal from DNA through double strand break???induced ubiquitylation, The Journal of Cell Biology, vol.19, issue.3, pp.467-79, 2008. ,
DOI : 10.1016/S0092-8674(00)80111-7
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2500133
Polymerases in Nonhomologous End Joining: Building a Bridge over Broken Chromosomes, Antioxidants & Redox Signaling, vol.14, issue.12, pp.2509-2528, 2011. ,
DOI : 10.1089/ars.2010.3429
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113452
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells, Nature Structural & Molecular Biology, vol.24, issue.8, pp.819-843, 2009. ,
DOI : 10.1038/nsmb.1641
URL : https://hal.archives-ouvertes.fr/hal-00413788
XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation, Nucleic Acids Research, vol.37, issue.2, pp.482-92, 2009. ,
DOI : 10.1093/nar/gkn957
URL : http://doi.org/10.1093/nar/gkn957
Coupled Homologous and Nonhomologous Repair of a Double-Strand Break Preserves Genomic Integrity in Mammalian Cells, Molecular and Cellular Biology, vol.20, issue.23, pp.9068-75, 2000. ,
DOI : 10.1128/MCB.20.23.9068-9075.2000
Ku is a 5???-dRP/AP lyase that excises nucleotide damage near broken ends, Nature, vol.26, issue.7292, pp.1214-1231, 2010. ,
DOI : 10.1038/nature08926
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859099
The role of the non-homologous end-joining pathway in lymphocyte development, Immunological Reviews, vol.14, issue.1, pp.115-146, 2004. ,
DOI : 10.1016/S0960-9822(01)00048-3
DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis, Cancer Letters, vol.332, issue.2, pp.237-285, 2012. ,
DOI : 10.1016/j.canlet.2012.01.007
Restraining the V(D)J recombinase, Nature Reviews Immunology, vol.3, issue.8, pp.656-66, 2003. ,
DOI : 10.1038/nri1152
Comparison of filler DNA at immune, nonimmune, and oncogenic rearrangements suggests multiple mechanisms of formation., Molecular and Cellular Biology, vol.9, issue.7, pp.3049-57, 1989. ,
DOI : 10.1128/MCB.9.7.3049
Cancer: New guardians of the genome, Nature, vol.404, issue.6780, pp.823-848, 2000. ,
DOI : 10.1038/35009180
V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes, Cell, vol.70, issue.6, pp.983-91, 1992. ,
DOI : 10.1016/0092-8674(92)90248-B
Mechanisms of nonhomologous recombination in mammalian cells., Molecular and Cellular Biology, vol.5, issue.10, pp.2599-607, 1985. ,
DOI : 10.1128/MCB.5.10.2599
Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction., Molecular and Cellular Biology, vol.6, issue.12, pp.4295-304, 1986. ,
DOI : 10.1128/MCB.6.12.4295
Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle, Molecular and Cellular Biology, vol.23, issue.16, pp.5706-5721, 2003. ,
DOI : 10.1128/MCB.23.16.5706-5715.2003
XRCC4's interaction with XLF is required for coding (but not signal) end joining, Nucleic Acids Research, vol.40, issue.4, pp.1684-94, 2012. ,
DOI : 10.1093/nar/gkr1315
URL : http://doi.org/10.1093/nar/gkr1315
V(D)J Recombination: Mechanisms of Initiation, Annual Review of Genetics, vol.45, issue.1, pp.167-202, 2011. ,
DOI : 10.1146/annurev-genet-110410-132552
Removal of Shelterin Reveals the Telomere End-Protection Problem, Science, vol.423, issue.6943, pp.593-97, 2012. ,
DOI : 10.1038/nature01688
ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks, Cell, vol.141, issue.6, pp.970-81, 2010. ,
DOI : 10.1016/j.cell.2010.04.038
URL : http://doi.org/10.1016/j.cell.2010.04.038
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more, Nature Reviews Molecular Cell Biology, vol.13, issue.4, pp.197-2105, 2013. ,
DOI : 10.4161/cc.23592
Regulation of DNA double-strand break repair pathway choice, Cell Research, vol.1, issue.1, pp.134-181, 2008. ,
DOI : 10.1038/nature04866
Bacterial DNA repair by non-homologous end joining, Nature Reviews Microbiology, vol.189, issue.11, pp.852-61, 2007. ,
DOI : 10.1038/nrmicro1768
DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation, PLoS Genetics, vol.140, issue.6, p.1002080, 2011. ,
DOI : 10.1371/journal.pgen.1002080.s007
URL : https://hal.archives-ouvertes.fr/inserm-00715279
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4???ligase IV during chromosomal translocation formation, Nature Structural & Molecular Biology, vol.5, issue.4, pp.410-426, 2010. ,
DOI : 10.1038/nsmb.1773
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893185
Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination, The Journal of Experimental Medicine, vol.159, issue.7, pp.1717-1744, 2007. ,
DOI : 10.4049/jimmunol.171.8.4062
URL : https://hal.archives-ouvertes.fr/hal-00167659
V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining, Oncogene, vol.159, issue.56, pp.7780-91, 2007. ,
DOI : 10.1128/MCB.24.20.9207-9220.2004
Positional stability of single double-strand breaks in mammalian cells, Nature Cell Biology, vol.211, issue.6, pp.675-82, 2007. ,
DOI : 10.1038/ncb1270
An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression, Cell, vol.151, issue.7, pp.1474-87, 2012. ,
DOI : 10.1016/j.cell.2012.11.054
Mechanism and Regulation of Class Switch Recombination, Annual Review of Immunology, vol.26, issue.1, pp.261-92, 2008. ,
DOI : 10.1146/annurev.immunol.26.021607.090248
Complex landscapes of somatic rearrangement in human breast cancer genomes, Nature, vol.82, issue.7276, pp.1005-1015, 2009. ,
DOI : 10.1038/nature08645
The MRE11 complex: starting from the ends, Nature Reviews Molecular Cell Biology, vol.30, issue.2, pp.90-103, 2011. ,
DOI : 10.1038/nrm3047
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905242
Specificity of Ku's 5 dRP/AP lyase promotes nonhomologous end joining (NHEJ) fidelity at damaged ends, J. Biol. Chem, vol.17, pp.13686-93, 2012. ,
DOI : 10.1074/jbc.m111.329730
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340204
Double-Strand Break End Resection and Repair Pathway Choice, Annual Review of Genetics, vol.45, issue.1, pp.247-71, 2011. ,
DOI : 10.1146/annurev-genet-110410-132435
Targeting Abnormal DNA Repair in Therapy-Resistant Breast Cancers, Molecular Cancer Research, vol.10, issue.1, pp.96-107, 2012. ,
DOI : 10.1158/1541-7786.MCR-11-0255
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319138
Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias, Oncogene, vol.16, issue.14, pp.1784-93, 2012. ,
DOI : 10.1038/onc.2012.203
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells, Proc. Natl. Acad. Sci. USA, pp.7720-7745, 2013. ,
DOI : 10.1038/nrg2593
Cernunnos Deficiency Reduces Thymocyte Life Span and Alters the T Cell Repertoire in Mice and Humans, Molecular and Cellular Biology, vol.33, issue.4, pp.701-712, 2012. ,
DOI : 10.1128/MCB.01057-12
Deletion of Ku86 causes early onset of senescence in mice, Proc. Natl. Acad. Sci. USA, pp.10770-75, 1999. ,
DOI : 10.1038/25292
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair, Nature, vol.412, issue.6847, pp.607-621, 2001. ,
DOI : 10.1038/35088000
Identification of a DNA Nonhomologous End-Joining Complex in Bacteria, Science, vol.297, issue.5587, pp.1686-89, 2002. ,
DOI : 10.1126/science.1074584
Somatic cells efficiently join unrelated DNA segments end-to-end., Molecular and Cellular Biology, vol.2, issue.10, pp.1258-69, 1982. ,
DOI : 10.1128/MCB.2.10.1258
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC369925/pdf
The Rad50 hook domain is a critical determinant of Mre11 complex functions, Nature Structural & Molecular Biology, vol.144, issue.5, pp.403-410, 2005. ,
DOI : 10.1016/S1097-2765(03)00035-2
Non-homologous end-joining partners in a helical dance: structural studies of XLF???XRCC4 interactions, Biochemical Society Transactions, vol.37, issue.5, pp.1387-92, 2011. ,
DOI : 10.1107/S0021889897006766
Role of mammalian Mre11 in classical and alternative nonhomologous end joining, Nature Structural & Molecular Biology, vol.31, issue.8, pp.814-832, 2009. ,
DOI : 10.1038/nsmb.1640
RPA Accumulation during Class Switch Recombination Represents 5??????3??? DNA-End Resection during the S???G2/M Phase of the Cell Cycle, Cell Reports, vol.3, issue.1, pp.138-185, 2013. ,
DOI : 10.1016/j.celrep.2012.12.006
IgH class switching and translocations use a robust non-classical end-joining pathway, Nature, vol.4, issue.7161, pp.478-82, 2007. ,
DOI : 10.1038/nature06020
Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein, Nucleic Acids Research, vol.27, issue.24, pp.4679-86, 1999. ,
DOI : 10.1093/nar/27.24.4679
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks, Nature, vol.296, issue.7329, pp.250-54, 2011. ,
DOI : 10.1038/nature09604
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058373
The Role of Mechanistic Factors in Promoting Chromosomal Translocations Found in Lymphoid and Other Cancers, Adv. Immunol, vol.106, pp.93-133, 2010. ,
DOI : 10.1016/S0065-2776(10)06004-9
An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway, Nature Structural & Molecular Biology, vol.8, issue.1, pp.80-84, 2011. ,
DOI : 10.1074/jbc.M909494199
Chromatin structural elements and chromosomal translocations in leukemia, DNA Repair, vol.5, issue.9-10, pp.1282-97, 2006. ,
DOI : 10.1016/j.dnarep.2006.05.020
Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates, Cell, vol.86, issue.3, pp.379-89, 1996. ,
DOI : 10.1016/S0092-8674(00)80111-7
Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations, Cell, vol.109, issue.7, pp.811-832, 2002. ,
DOI : 10.1016/S0092-8674(02)00770-5
URL : http://doi.org/10.1016/s0092-8674(02)00770-5
53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection, Science, vol.151, issue.2, pp.700-704, 2013. ,
DOI : 10.1016/j.jsb.2005.06.002
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664841
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway, Nature Cell Biology, vol.15, issue.8, pp.870-769, 2006. ,
DOI : 10.1038/ncb1446
Estimation and Partition of Heritability in Human Populations Using Whole-Genome Analysis Methods, p75 Detecting Natural Selection in Genomic Data Joseph J. Vitti, Sharon R. Grossman, and Pardis C, pp.51-97 ,