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Journal articles
Progress toward treatments for synaptic defects in autism.
Abstract : Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. For the majority of affected individuals, the cause of ASD remains unknown, but in at least 20% of the cases, a genetic cause can be identified. There is currently no cure for ASD; however, results from mouse models indicate that some forms of the disorder could be alleviated even at the adult stage. Genes involved in ASD seem to converge on common pathways altering synaptic homeostasis. We propose, given the clinical heterogeneity of ASD, that specific 'synaptic clinical trials' should be designed and launched with the aim of establishing whether phenotype 'reversals' could also occur in humans.
Cited literature [118 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01470299
Contributor : Elodie Ey <>
Submitted on : Tuesday, February 26, 2019 - 1:17:57 PM
Last modification on : Thursday, August 26, 2021 - 11:34:07 AM
Long-term archiving on: : Monday, May 27, 2019 - 2:11:58 PM
Contributor : Elodie Ey <>
Submitted on : Tuesday, February 26, 2019 - 1:17:57 PM
Last modification on : Thursday, August 26, 2021 - 11:34:07 AM
Long-term archiving on: : Monday, May 27, 2019 - 2:11:58 PM
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Progress_treatments_autism.pdf
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