Progress toward treatments for synaptic defects in autism.

Richard Delorme; Elodie Ey; Roberto Toro; Marion Leboyer; Christopher Gillberg; Thomas Bourgeron

doi:10.1038/nm.3193

Progress toward treatments for synaptic defects in autism.

Richard Delorme ^{1, 2, 3} Elodie Ey ^{1, 3} Roberto Toro ^{1, 3} Marion Leboyer ^{4, 5} Christopher Gillberg ^{6, 7, 8} Thomas Bourgeron ^{1, 3, 5, *}

* Auteur correspondant

1 Génétique Humaine et Fonctions Cognitives

2 Service Psychiatrie de l'Enfant et de l'Adolescent

3 Gènes, Synapses et Cognition

4 IMRB - Institut Mondor de Recherche Biomédicale

5 Fondation FondaMental

6 UCL - University College of London [London]

7 University of Glasgow

8 Gillberg Neuropsychiatry Centre

Abstract : Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. For the majority of affected individuals, the cause of ASD remains unknown, but in at least 20% of the cases, a genetic cause can be identified. There is currently no cure for ASD; however, results from mouse models indicate that some forms of the disorder could be alleviated even at the adult stage. Genes involved in ASD seem to converge on common pathways altering synaptic homeostasis. We propose, given the clinical heterogeneity of ASD, that specific 'synaptic clinical trials' should be designed and launched with the aim of establishing whether phenotype 'reversals' could also occur in humans.

Type de document :

Article dans une revue

Nature Medicine, Nature Publishing Group, 2013, 19 (6), pp.685-94. 〈10.1038/nm.3193〉

Domaine :

Sciences du Vivant [q-bio] / Génétique / Génétique humaine

Sciences du Vivant [q-bio] / Neurosciences [q-bio.NC]

Liste complète des métadonnées

https://hal-pasteur.archives-ouvertes.fr/pasteur-01470299
Contributeur : Elodie Ey <>
Soumis le : vendredi 17 février 2017 - 11:39:11
Dernière modification le : jeudi 11 janvier 2018 - 06:26:04

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