M. Rottmann, C. Mcnamara, B. K. Yeung, M. C. Lee, B. Zou et al., Spiroindolones, a Potent Compound Class for the Treatment of Malaria, 2010) Spiroindolones, a potent compound class for the treatment of malaria, pp.1175-1180
DOI : 10.1126/science.1193225

F. J. Gamo, L. M. Sanz, J. Vidal, C. De-cozar, E. Alvarez et al., Thousands of chemical starting points for antimalarial lead identification, Nature, vol.8, issue.7296, pp.305-310, 2010.
DOI : 10.1038/nature09107

W. A. Guiguemde, A. A. Shelat, J. F. Garcia-bustos, T. T. Diagana, F. J. Gamo et al., Global Phenotypic Screening for Antimalarials, Chemistry & Biology, vol.19, issue.1, pp.116-129, 2012.
DOI : 10.1016/j.chembiol.2012.01.004

URL : http://doi.org/10.1016/j.chembiol.2012.01.004

S. Déchamps, S. Shastri, K. Wengelnik, and H. J. Vial, Glycerophospholipid acquisition in Plasmodium ??? A puzzling assembly of biosynthetic pathways, International Journal for Parasitology, vol.40, issue.12, pp.1347-1365, 2010.
DOI : 10.1016/j.ijpara.2010.05.008

O. M. Klibanov, S. H. Williams, L. S. Smith, J. L. Olin, and S. B. Vickery, Telaprevir: A Novel NS3/4 Protease Inhibitor for the Treatment of Hepatitis C, Pharmacotherapy, vol.350, issue.10, pp.951-974, 2011.
DOI : 10.1128/AAC.00863-07

P. J. Rosenthal, Falcipains and Other Cysteine Proteases of Malaria Parasites, Adv. Exp. Med. Biol, vol.712, pp.30-48, 2011.
DOI : 10.1007/978-1-4419-8414-2_3

K. K. Ang, J. Ratnam, J. Gut, J. Legac, E. Hansell et al., Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads, PLoS Neglected Tropical Diseases, vol.52, issue.Pt 5, p.1023, 2011.
DOI : 10.1371/journal.pntd.0001023.t005

URL : http://doi.org/10.1371/journal.pntd.0001023

Z. S. Saify, M. K. Azim, W. Ahmad, M. Nisa, D. E. Goldberg et al., New benzimidazole derivatives as antiplasmodial agents and plasmepsin inhibitors: Synthesis and analysis of structure???activity relationships, Bioorganic & Medicinal Chemistry Letters, vol.22, issue.2, pp.1282-1286, 2012.
DOI : 10.1016/j.bmcl.2011.10.018

I. Russo, S. Babbitt, V. Muralidharan, T. Butler, A. Oksman et al., Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte, Nature, vol.68, issue.7281, pp.632-636, 2010.
DOI : 10.1038/nature08726

J. A. Boddey, A. N. Hodder, S. Günther, P. R. Gilson, H. Patsiouras et al., An aspartyl protease directs malaria effector proteins to the host cell, Nature, vol.340, issue.7281, pp.627-631, 2010.
DOI : 10.1038/nature08728

M. J. Meyers and D. E. Goldberg, Recent Advances in Plasmepsin Medicinal Chemistry and Implications for Future Antimalarial Drug Discovery Efforts, Current Topics in Medicinal Chemistry, vol.12, issue.5, pp.445-455, 2012.
DOI : 10.2174/156802612799362959

D. E. Goldberg and A. F. Cowman, Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes, Nature Reviews Microbiology, vol.147, issue.9, pp.617-621, 2010.
DOI : 10.1038/nrmicro2420

T. J. Dowse, K. Koussis, M. J. Blackman, and D. Soldati-favre, Roles of Proteases during Invasion and Egress by Plasmodium and Toxoplasma, Subcell. Biochem, vol.47, pp.121-139, 2008.
DOI : 10.1007/978-0-387-78267-6_10

M. J. Blackman, Malarial proteases and host cell egress: an ???emerging??? cascade, Cellular Microbiology, vol.131, issue.Suppl. 3, pp.1925-1934, 2008.
DOI : 10.1111/j.1462-5822.2008.01176.x

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610400

S. Yeoh, R. A. O-'donnell, K. Koussis, A. R. Dluzewski, K. H. Ansell et al., Subcellular Discharge of a Serine Protease Mediates Release of Invasive Malaria Parasites from Host Erythrocytes, Cell, vol.131, issue.6, pp.1072-1083, 2007.
DOI : 10.1016/j.cell.2007.10.049

K. Koussis, C. Withers-martinez, S. Yeoh, M. Child, F. Hackett et al., A multifunctional serine protease primes the malaria parasite for red blood cell invasion, The EMBO Journal, vol.72, issue.6, pp.725-735, 2009.
DOI : 10.1016/j.cell.2007.10.049

J. C. Barale, T. Blisnick, H. Fujioka, P. M. Alzari, M. Aikawa et al., Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase, Proc. Natl. Acad. Sci. U.S.A. 96, pp.6445-6450, 1999.
DOI : 10.1073/pnas.96.11.6445

URL : https://hal.archives-ouvertes.fr/hal-00126410

G. Bastianelli, A. Bouillon, C. Nguyen, E. Crublet, S. Pêtres et al., Computational Reverse-Engineering of a Spider-Venom Derived Peptide Active Against Plasmodium falciparum SUB1, PLoS ONE, vol.4, issue.7, p.21812, 2011.
DOI : 10.1371/journal.pone.0021812.t004

C. Withers-martinez, J. W. Saldanha, B. Ely, F. Hackett, T. O-'connor et al., Expression of Recombinant Plasmodium falciparum Subtilisin-like Protease-1 in Insect Cells. CHARACTERIZATION, COMPARISON WITH THE PARASITE PROTEASE, AND HOMOLOGY MODELING, Journal of Biological Chemistry, vol.277, issue.33, pp.29698-29709, 2002.
DOI : 10.1074/jbc.M203088200

C. Withers-martinez, C. Suarez, S. Fulle, S. Kher, M. Penzo et al., Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target, International Journal for Parasitology, vol.42, issue.6, pp.597-612, 2012.
DOI : 10.1016/j.ijpara.2012.04.005

R. Grünberg, M. Nilges, and J. Leckner, Biskit A software platform for structural bioinformatics, Bioinformatics, vol.23, issue.6, pp.769-770, 2007.
DOI : 10.1093/bioinformatics/btl655

O. Sullivan, O. Suhre, K. Abergel, C. Higgins, D. G. Notredame et al., 3DCoffee: Combining Protein Sequences and Structures within Multiple Sequence Alignments, Journal of Molecular Biology, vol.340, issue.2, pp.385-395, 2004.
DOI : 10.1016/j.jmb.2004.04.058

A. Sali and T. L. Blundell, Comparative Protein Modelling by Satisfaction of Spatial Restraints, Journal of Molecular Biology, vol.234, issue.3, pp.779-815, 1993.
DOI : 10.1006/jmbi.1993.1626

J. A. Dalton, J. , and R. M. , An evaluation of automated homology modelling methods at low target template sequence similarity, Bioinformatics, vol.23, issue.15, 1901.
DOI : 10.1093/bioinformatics/btm262

P. Larsson, B. Wallner, E. Lindahl, and A. Elofsson, Using multiple templates to improve quality of homology models in automated homology modeling, Protein Science, vol.57, issue.6, pp.990-1002, 2008.
DOI : 10.1110/ps.073344908

S. F. Altschul, W. Gish, W. Miller, E. W. Myers, and D. J. Lipman, Basic local alignment search tool, Journal of Molecular Biology, vol.215, issue.3, pp.403-410, 1990.
DOI : 10.1016/S0022-2836(05)80360-2

J. Sadowski, A hybrid approach for addressing ring flexibility in 3D database searching, Journal of Computer-Aided Molecular Design, vol.11, issue.1, pp.53-60, 1997.
DOI : 10.1023/A:1008023427310

M. Totrov and R. Abagyan, Flexible protein-ligand docking by global energy optimization in internal coordinates, Proteins, pp.215-220, 1997.

M. Rarey, B. Kramer, T. Lengauer, and G. Klebe, A Fast Flexible Docking Method using an Incremental Construction Algorithm, Journal of Molecular Biology, vol.261, issue.3, pp.470-489, 1996.
DOI : 10.1006/jmbi.1996.0477

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=

M. Schapira, M. Totrov, and R. Abagyan, Prediction of the binding energy for small molecules, peptides and proteins, Journal of Molecular Recognition, vol.3, issue.3, pp.177-190, 1999.
DOI : 10.1002/(SICI)1099-1352(199905/06)12:3<177::AID-JMR451>3.0.CO;2-Z

S. A. Hindle, M. Rarey, C. Buning, and T. Lengaue, Flexible docking under pharmacophore type constraints, Journal of Computer-Aided Molecular Design, vol.16, issue.2, pp.129-149, 2002.
DOI : 10.1023/A:1016399411208

R. E. Desjardins, C. J. Canfield, J. D. Haynes, C. , and J. D. , Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique., Antimicrobial Agents and Chemotherapy, vol.16, issue.6, pp.710-718, 1979.
DOI : 10.1128/AAC.16.6.710

B. L. Salmon, A. Oksman, and D. E. Goldberg, Malaria parasite exit from the host erythrocyte: A two-step process requiring extraerythrocytic proteolysis, Proceedings of the National Academy of Sciences, vol.98, issue.1, pp.271-276, 2001.
DOI : 10.1073/pnas.98.1.271

Q. Li, L. Gerena, L. Xie, J. Zhang, D. Kyle et al., Development and validation of flow cytometric measurement for parasitemia in cultures ofP. falciparum vitally stained with YOYO-1, Cytometry Part A, vol.99, issue.5, pp.297-307, 2007.
DOI : 10.1002/cyto.a.20380

T. Ishino, Y. Orito, Y. Chinzei, Y. , and M. , A calcium-dependent protein kinase regulates Plasmodium ookinete access to the midgut epithelial cell, Molecular Microbiology, vol.59, issue.4, pp.1175-1184, 2006.
DOI : 10.1016/S0166-6851(01)00304-8

D. A. Fidock, P. J. Rosenthal, S. L. Croft, R. Brun, and S. Nwaka, Antimalarial drug discovery: efficacy models for compound screening, Nature Reviews Drug Discovery, vol.91, issue.6, pp.509-520, 2004.
DOI : 10.1038/nrd1416

R. J. Siezen and J. A. And-leunissen, Subtilases: The superfamily of subtilisin-like serine proteases, Protein Science, vol.270, issue.5, pp.501-523, 1997.
DOI : 10.1002/pro.5560060301

V. Grum-tokars, K. Ratia, A. Begaye, S. C. Baker, and A. D. Mesecar, Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery, Virus Research, vol.133, issue.1, pp.63-73, 2008.
DOI : 10.1016/j.virusres.2007.02.015

M. J. Blackman, H. Fujioka, W. H. Stafford, M. Sajid, B. Clough et al., A Subtilisin-like Protein in Secretory Organelles of Plasmodium falciparum Merozoites, Journal of Biological Chemistry, vol.273, issue.36, pp.23398-23409, 1998.
DOI : 10.1074/jbc.273.36.23398

S. L. Mcgovern and B. K. Shoichet, Information Decay in Molecular Docking Screens against Holo, Apo, and Modeled Conformations of Enzymes, Journal of Medicinal Chemistry, vol.46, issue.14, pp.2895-2907, 2003.
DOI : 10.1021/jm0300330

P. Gros, A. V. Teplyakov, and W. G. Hol, Effects of eglin-c binding to thermitase: Three-dimensional structure comparison of native thermitase and thermitase eglin-c complexes, Proteins: Structure, Function, and Genetics, vol.42, issue.1, pp.63-74, 1992.
DOI : 10.1002/prot.340120108

I. R. Laskowski, M. W. Macarthur, D. S. Moss, T. , and J. M. , PROCHECK: a program to check the stereochemical quality of protein structures, Journal of Applied Crystallography, vol.26, issue.2, pp.283-291, 1993.
DOI : 10.1107/S0021889892009944

L. Jean, C. Withers-martinez, F. Hackett, and M. J. Blackman, Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity, Molecular and Biochemical Parasitology, vol.144, issue.2, pp.187-197, 2005.
DOI : 10.1016/j.molbiopara.2005.07.008

A. Fiser and A. Sali, ModLoop: automated modeling of loops in protein structures, Bioinformatics, vol.19, issue.18, pp.2500-2501, 2003.
DOI : 10.1093/bioinformatics/btg362

A. Berger and I. Schechter, Mapping the Active Site of Papain with the Aid of Peptide Substrates and Inhibitors, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.257, issue.813, pp.249-264, 1970.
DOI : 10.1098/rstb.1970.0024

H. Grøn, M. Meldal, and K. Breddam, Extensive comparison of the substrate preferences of two subtilisins as determined with peptide substrates which are based on the principle of intramolecular quenching, Biochemistry, vol.31, issue.26, pp.6011-6018, 1992.
DOI : 10.1021/bi00141a008

G. Nicola, C. A. Smith, and R. Abagyan, New Method for the Assessment of All Drug-Like Pockets Across a Structural Genome, Journal of Computational Biology, vol.15, issue.3, pp.231-240, 2008.
DOI : 10.1089/cmb.2007.0178

I. Safeukui, F. Mangou, D. Malvy, P. Vincendeau, D. Mossalayi et al., Plasmodium berghei: dehydroepiandrosterone sulfate reverses chloroquino-resistance in experimental malaria infection; correlation with glucose 6-phosphate dehydrogenase and glutathione synthesis pathway, Biochemical Pharmacology, vol.68, issue.10, 1903.
DOI : 10.1016/j.bcp.2004.05.049

S. Gemma, S. Giovani, M. Brindisi, P. Tripaldi, S. Brogi et al., Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1, Bioorganic & Medicinal Chemistry Letters, vol.22, issue.16, pp.5317-5321, 2012.
DOI : 10.1016/j.bmcl.2012.06.023

S. Meister, D. M. Plouffe, K. L. Kuhen, G. M. Bonamy, T. Wu et al., Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery, Science, vol.334, issue.6061, pp.1372-1377, 2011.
DOI : 10.1126/science.1211936