The Diverse Family of Arp2/3 Complexes.

Javier Pizarro-Cerdá (1) , Dror Shlomo Chorev (2) , Benjamin Geiger (2) , Pascale Cossart (1)

1 UIBC - Interactions Bactéries-Cellules
2 Weizmann Institute of Science [Rehovot, Israël]

The Arp2/3 complex has so far been considered to be a single seven-subunit protein complex required for actin nucleation and actin filament polymerization in diverse critical cellular functions including phagocytosis, vesicular trafficking and lamellipodia extension. The Arp2/3 complex is also exploited by bacterial pathogens and viruses during cellular infectious processes. Recent studies suggest that some subunits of the complex are dispensable in specific cellular contexts, pointing to the existence of alternative 'hybrid Arp2/3 complexes' containing other components such as vinculin or α-actinin, as well as different isoforms or phosphorylation variants of canonical Arp2/3 subunits. Therefore, this diversity should be now considered when assigning specific Arp2/3 assemblies to different actin-dependent cellular processes.

Keywords: vaccinia virus; Listeria monocytogenes; actin polymerization; focal adhesions; Arp2/3

Domains: Subcellular Processes [q-bio.SC]

Javier Pizarro-Cerdá, Dror Shlomo Chorev, Benjamin Geiger, Pascale Cossart. The Diverse Family of Arp2/3 Complexes.. Trends in Cell Biology, 2017, 27 (2), pp.93-100. ⟨10.1016/j.tcb.2016.08.001⟩. ⟨pasteur-01457856⟩