 |
Journal articles
Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study.
Van-Mai Cao-Lormeau
1
Alexandre Blake
2
Sandrine Mons
3
Stéphane Lastère
3
Claudine Roche
1
Jessica Vanhomwegen
4, 5
Timothée Dub
2
Laure Baudouin
3
Anita Teissier
2
Philippe Larre
3
Anne-Laure Vial
6
Christophe Decam
7
Valérie Choumet
4
Susan K Halstead
8
Hugh J Willison
8
Lucile Musset
9
Jean Manuguerra
4, 5
Philippe Desprès
10
Emmanuel Fournier
9
Henri-Pierre Mallet
11
Didier Musso
1
Arnaud Fontanet
12, 2, 13
Jean Neil
9
Frédéric Ghawché
3
Van-Mai Cao-Lormeau 1
Author
Alexandre Blake 2
Author
Sandrine Mons 3
Author
Stéphane Lastère 3
Author
Claudine Roche 1
Author
Jessica Vanhomwegen 4, 5
Author IdHAL : jessica-vanhomwegen ORCID : https://orcid.org/0000-0002-7879-1485
Timothée Dub 2
Author
Laure Baudouin 3
Author
Jean Manuguerra 4, 5
Author
Philippe Desprès 10
Author
Emmanuel Fournier 9
Author
Henri-Pierre Mallet 11
Author
1
ILM - Institut Louis Malardé [Papeete] (BP 30, 98713 Papeete Tahiti - French Polynesia)
- IRD - Institut de Recherche pour le Développement (Siège Le Sextant 44, bd de Dunkerque CS 90009 13572 Marseille cedex 02 - France)
2
Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology (Département Infection et Epidémiologie, 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)
- PACRI - Pasteur-Cnam risques infectieux et émergents (Paris - France)
- CNAM - Conservatoire National des Arts et Métiers [CNAM] (France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
3
Centre Hospitalier de Polynésie Française (Papeete - French Polynesia)
4
ERI - Environnement et Risques infectieux - Environment and Infectious Risks (Département Infection et Epidémiologie, 28, rue du Docteur Roux, 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
5
CIBU - Cellule d'Intervention Biologique d'Urgence - Laboratory for Urgent Response to Biological Threats (Département Infection et Epidémiologie, 25-28 rue du Docteur Roux F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
6
Direction de la Santé - Bureau de veille sanitaire [Papeete] (French Polynesia)
7
Service de santé des forces armées [Papeete] (French Polynesia)
8
University of Glasgow (Glasgow G12 8QQ Scotland - United Kingdom)
9
CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
10
PIMIT - Processus Infectieux en Milieu Insulaire Tropical (Plateforme de recherche CYROI - 2 rue Maxime-Rivière 97491 Sainte Clotilde - La Réunion - Réunion)
- CNRS - Centre National de la Recherche Scientifique : UMR9192 (France)
- IRD : UMR249 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1187 (101, rue de Tolbiac, 75013 Paris - France)
- UR - Université de La Réunion : UM134 (15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9 - Réunion)
11
Direction de la Santé de la Polynésie Française (Papeete - French Polynesia)
12
CGH - Center for Global Health (25-28, rue du Docteur Roux
75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
Résumé : Between October, 2013, and April, 2014, French Polynesia experienced the largest Zika virus outbreak ever described at that time. During the same period, an increase in Guillain-Barré syndrome was reported, suggesting a possible association between Zika virus and Guillain-Barré syndrome. We aimed to assess the role of Zika virus and dengue virus infection in developing Guillain-Barré syndrome.
Résumé : In this case-control study, cases were patients with Guillain-Barré syndrome diagnosed at the Centre Hospitalier de Polynésie Française (Papeete, Tahiti, French Polynesia) during the outbreak period. Controls were age-matched, sex-matched, and residence-matched patients who presented at the hospital with a non-febrile illness (control group 1; n=98) and age-matched patients with acute Zika virus disease and no neurological symptoms (control group 2; n=70). Virological investigations included RT-PCR for Zika virus, and both microsphere immunofluorescent and seroneutralisation assays for Zika virus and dengue virus. Anti-glycolipid reactivity was studied in patients with Guillain-Barré syndrome using both ELISA and combinatorial microarrays.
Résumé : 42 patients were diagnosed with Guillain-Barré syndrome during the study period. 41 (98%) patients with Guillain-Barré syndrome had anti-Zika virus IgM or IgG, and all (100%) had neutralising antibodies against Zika virus compared with 54 (56%) of 98 in control group 1 (p<0.0001). 39 (93%) patients with Guillain-Barré syndrome had Zika virus IgM and 37 (88%) had experienced a transient illness in a median of 6 days (IQR 4-10) before the onset of neurological symptoms, suggesting recent Zika virus infection. Patients with Guillain-Barré syndrome had electrophysiological findings compatible with acute motor axonal neuropathy (AMAN) type, and had rapid evolution of disease (median duration of the installation and plateau phases was 6 [IQR 4-9] and 4 days [3-10], respectively). 12 (29%) patients required respiratory assistance. No patients died. Anti-glycolipid antibody activity was found in 13 (31%) patients, and notably against GA1 in eight (19%) patients, by ELISA and 19 (46%) of 41 by glycoarray at admission. The typical AMAN-associated anti-ganglioside antibodies were rarely present. Past dengue virus history did not differ significantly between patients with Guillain-Barré syndrome and those in the two control groups (95%, 89%, and 83%, respectively).
Document type :
Journal articles
Complete list of metadatas
https://hal-pasteur.archives-ouvertes.fr/pasteur-01453407
Contributor : Valérie Choumet <>
Submitted on : Thursday, February 2, 2017 - 5:43:42 PM
Last modification on : Friday, October 30, 2020 - 3:06:06 AM
Contributor : Valérie Choumet <>
Submitted on : Thursday, February 2, 2017 - 5:43:42 PM
Last modification on : Friday, October 30, 2020 - 3:06:06 AM
Links full text
Identifiers
- HAL Id : pasteur-01453407, version 1
- DOI : 10.1016/S0140-6736(16)00562-6
- PUBMED : 26948433
Collections
PASTEUR | CNRS | CNAM | RIIP | PIMIT | UNIV-HESAM | PAPANGUE | AFRIQ | UNIV-REUNION
Citation
Van-Mai Cao-Lormeau, Alexandre Blake, Sandrine Mons, Stéphane Lastère, Claudine Roche, et al.. Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study.. Lancet, Elsevier, 2016, pp.1531-9. ⟨10.1016/S0140-6736(16)00562-6⟩. ⟨pasteur-01453407⟩
Metrics
Record views