Infection-Mediated Priming of Phagocytes Protects against Lethal Secondary Aspergillus fumigatus Challenge.

Abstract : Phagocytes restrict the germination of Aspergillus fumigatus conidia and prevent the establishment of invasive pulmonary aspergillosis in immunecompetent mice. Here we report that immunecompetent mice recovering from a primary A. fumigatus challenge are protected against a secondary lethal challenge. Using RAGγc knock-out mice we show that this protection is independent of T, B and NK cells. In protected mice, lung phagocytes are recruited more rapidly and are more efficient in conidial phagocytosis and killing. Protection was also associated with an enhanced expression of CXCR2 and Dectin-1 on bone marrow phagocytes. We also show that protective lung cytokine and chemokine responses are induced more rapidly and with enhanced dynamics in protected mice. Our findings support the hypothesis that following a first encounter with a non-lethal dose of A. fumigatus conidia, the innate immune system is primed and can mediate protection against a secondary lethal infection.
Type de document :
Article dans une revue
PLoS ONE, Public Library of Science, 2016, 11 (4), pp.e0153829. 〈10.1371/journal.pone.0153829〉
Liste complète des métadonnées

Littérature citée [20 références]  Voir  Masquer  Télécharger

https://hal-pasteur.archives-ouvertes.fr/pasteur-01448226
Contributeur : Bénédicte Benedic <>
Soumis le : vendredi 27 janvier 2017 - 16:21:45
Dernière modification le : jeudi 22 mars 2018 - 15:56:02
Document(s) archivé(s) le : vendredi 28 avril 2017 - 23:27:27

Fichier

2016.Plos.One.Aspergillus.pdf
Publication financée par une institution

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Citation

Amélie Savers, Orhan Rasid, Marianna Parlato, Matthias Brock, Gregory Jouvion, et al.. Infection-Mediated Priming of Phagocytes Protects against Lethal Secondary Aspergillus fumigatus Challenge.. PLoS ONE, Public Library of Science, 2016, 11 (4), pp.e0153829. 〈10.1371/journal.pone.0153829〉. 〈pasteur-01448226〉

Partager

Métriques

Consultations de la notice

82

Téléchargements de fichiers

162