Astrovirus Diagnostics.

Philippe Pérot (1, 2) , Marc Lecuit (3, 2, 4) , Marc Eloit (5, 2)

1 CITECH - Centre de Recherche et Innovation Technologique
2 Biologie des Infections - Biology of Infection
3 UPD5 - Université Paris Descartes - Paris 5
4 CHU Necker - Enfants Malades [AP-HP]
5 ENVA - École nationale vétérinaire - Alfort

Various methods exist to detect an astrovirus infection. Current methods include electron microscopy (EM), cell culture, immunoassays, polymerase chain reaction (PCR) and various other molecular approaches that can be applied in the context of diagnostic or in surveillance studies. With the advent of metagenomics, novel human astrovirus (HAstV) strains have been found in immunocompromised individuals in association with central nervous system (CNS) infections. This work reviews the past and current methods for astrovirus detection and their uses in both research laboratories and for medical diagnostic purposes.

Keywords: detection methods; molecular diagnostics; astrovirus; virology

Domains: Life Sciences [q-bio]

Philippe Pérot, Marc Lecuit, Marc Eloit. Astrovirus Diagnostics.. Viruses, 2017, 9 (1), ⟨10.3390/v9010010⟩. ⟨pasteur-01441063⟩