In vivo cellular tropism of gorilla simian foamy virus in blood of infected humans.

Résumé : Simian foamy viruses (SFV) are retroviruses that are widespread among nonhuman primates. SFV can be transmitted to humans, giving rise to a persistent infection. Only a few data are available concerning the distribution of SFV in human blood cells. Here we purified blood mononuclear cell subsets from 11 individuals infected with a Gorilla gorilla SFV strain and quantified SFV DNA levels by quantitative PCR. SFV DNA was detected in the majority of the CD8(+), CD4(+), and CD19(+) lymphocyte samples and rarely in CD14(+) monocyte and CD56(+) NK lymphocyte samples. The median (interquartile range [IQR]) SFV DNA counts were 16.0 (11.0 to 49.8), 11.3 (5.9 to 28.3), and 17.2 (2.0 to 25.2) copies/10(5) cells in CD8(+) T lymphocytes, CD4(+) T lymphocytes, and CD19(+) B lymphocytes, respectively. In the CD4 compartment, SFV DNA was detected in both memory and naive CD4(+) T lymphocytes. SFV DNA levels in CD4(+) T cells were positively correlated with the duration of the infection. Our study shows with a quantitative method that CD8(+), CD4(+), and B lymphocytes are major cellular targets of SFV in the blood of infected humans.
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Soumis le : mercredi 4 janvier 2017 - 15:42:48
Dernière modification le : jeudi 11 janvier 2018 - 06:25:39

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Rejane Rua, Edouard Betsem, Thomas Montange, Florence Buseyne, Antoine Gessain. In vivo cellular tropism of gorilla simian foamy virus in blood of infected humans.. Journal of Virology, American Society for Microbiology, 2014, 88 (22), pp.13429-35. 〈10.1128/JVI.01801-14〉. 〈pasteur-01426496〉

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