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Bacteriophages Can Treat and Prevent Pseudomonas aeruginosa Lung Infections

Abstract : Antibiotic-resistant bacteria threaten life worldwide. Although new antibiotics are scarce, the use of bacteriophages, viruses that infect bacteria, is rarely proposed as a means of offsetting this shortage. Doubt also remains widespread about the efficacy of phage therapy despite recent encouraging results. Using a bioluminescent Pseudomonas aeruginosa strain, we monitored and quantified the efficacy of a bacteriophage treatment in mice during acute lung infection. Bacteriophage treatment not only was effective in saving animals from lethal infection, but also was able to prevent lung infection when given 24 h before bacterial infection, thereby extending the potential use of bacteriophages as therapeutic agents to combat bacterial lung infection.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01425464
Contributor : Laurent Debarbieux <>
Submitted on : Tuesday, January 3, 2017 - 3:44:38 PM
Last modification on : Monday, October 12, 2020 - 10:58:02 AM
Long-term archiving on: : Tuesday, April 4, 2017 - 2:35:49 PM

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Laurent Debarbieux, Dominique Leduc, Damien Maura, Eric Morello, Alexis Criscuolo, et al.. Bacteriophages Can Treat and Prevent Pseudomonas aeruginosa Lung Infections. Journal of Infectious Diseases, Oxford University Press (OUP), 2010, 201 (7), pp.1096 - 1104. ⟨10.1086/651135⟩. ⟨pasteur-01425464⟩

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