Abstract : Antibiotic resistance development has been linked to the bacterial SOS stress response. In Escherichia coli, fluoroquinolones are known to induce SOS, whereas other antibiotics, such as aminoglycosides, tetracycline, and chloramphenicol, do not. Here we address whether various antibiotics induce SOS in Vibrio cholerae. Reporter green fluorescent protein (GFP) fusions were used to measure the response of SOS-regulated promoters to subinhibitory concentrations of antibiotics. We show that unlike the situation with E. coli, all these antibiotics induce SOS in V. cholerae.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01423615
Contributor : Isabelle Hoffmann
<>
Submitted on : Friday, December 30, 2016 - 4:19:28 PM
Last modification on : Thursday, January 11, 2018 - 6:20:30 AM
Long-term archiving on : Tuesday, March 21, 2017 - 5:08:02 AM
Zeynep Baharoglu, Didier Mazel. Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2011, 55 (5), pp.2438-2441. ⟨10.1128/AAC.01549-10⟩. ⟨pasteur-01423615⟩
