Abstract : Antibiotic resistance development has been linked to the bacterial SOS stress response. In Escherichia coli, fluoroquinolones are known to induce SOS, whereas other antibiotics, such as aminoglycosides, tetracycline, and chloramphenicol, do not. Here we address whether various antibiotics induce SOS in Vibrio cholerae. Reporter green fluorescent protein (GFP) fusions were used to measure the response of SOS-regulated promoters to subinhibitory concentrations of antibiotics. We show that unlike the situation with E. coli, all these antibiotics induce SOS in V. cholerae.
Type de document :
Article dans une revue
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2011, 55 (5), pp.2438-2441. 〈10.1128/AAC.01549-10〉
https://hal-pasteur.archives-ouvertes.fr/pasteur-01423615
Contributeur : Isabelle Hoffmann
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Soumis le : vendredi 30 décembre 2016 - 16:19:28
Dernière modification le : jeudi 11 janvier 2018 - 06:20:30
Document(s) archivé(s) le : mardi 21 mars 2017 - 05:08:02
Zeynep Baharoglu, Didier Mazel. Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2011, 55 (5), pp.2438-2441. 〈10.1128/AAC.01549-10〉. 〈pasteur-01423615〉
