Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli. - Archive ouverte HAL Access content directly
Journal Articles Research in Microbiology Year : 2014

Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli.

(1) , (1)
1

Abstract

Low concentrations of aminoglycosides induce the SOS response in Vibrio cholerae but not in Escherichia coli. In order to determine whether a specific factor present in E. coli prevents this induction, we developed a genetic screen where only SOS inducing mutants are viable. We identified the vsr gene coding for the Vsr protein of the very short patch mismatch repair (VSPR) pathway. The effect of mismatch repair (MMR) mutants was also studied. We propose that lesions formed upon aminoglycoside treatment are preferentially repaired by VSPR without SOS induction in E. coli and by MMR when VSPR is impaired.
Fichier principal
Vignette du fichier
ms_may_2014.pdf (1.53 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

pasteur-01423361 , version 1 (02-02-2017)

Licence

Attribution - NonCommercial - ShareAlike - CC BY 4.0

Identifiers

Cite

Zeynep Baharoglu, Didier Mazel. Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli.. Research in Microbiology, 2014, 165 (6), pp.476-80. ⟨10.1016/j.resmic.2014.05.039⟩. ⟨pasteur-01423361⟩

Collections

PASTEUR CNRS
288 View
234 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More