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Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin

Abstract : Background: Translocation of the CyaA toxin across plasma membrane is still poorly understood. Results: The region 375– 485 is involved in membrane destabilization in vitro and required for cell intoxication. Conclusion: The region 375– 485 is crucial for membrane insertion and translocation of the catalytic domain of CyaA. Significance: These results provide new insights on the early stages of the cell intoxication process.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01423063
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Submitted on : Wednesday, December 28, 2016 - 11:31:35 AM
Last modification on : Wednesday, June 8, 2022 - 4:14:04 PM
Long-term archiving on: : Monday, March 20, 2017 - 10:46:33 PM

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Johanna C. Karst, Robert Barker, Usha Devi, Marcus J. Swann, Marilyne Davi, et al.. Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin. Journal of Biological Chemistry, 2012, 287 (12), pp.9200 - 9212. ⟨10.1074/jbc.M111.316166⟩. ⟨pasteur-01423063⟩

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