Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin

Abstract : Background: Translocation of the CyaA toxin across plasma membrane is still poorly understood. Results: The region 375– 485 is involved in membrane destabilization in vitro and required for cell intoxication. Conclusion: The region 375– 485 is crucial for membrane insertion and translocation of the catalytic domain of CyaA. Significance: These results provide new insights on the early stages of the cell intoxication process.
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Johanna C. Karst, Robert Barker, Usha Devi, Marcus J. Swann, Marilyne Davi, et al.. Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (12), pp.9200 - 9212. ⟨10.1074/jbc.M111.316166⟩. ⟨pasteur-01423063⟩

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