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Journal Articles Nature Microbiology Year : 2016

Global phylogeography and evolutionary history of Shigella dysenteriae type 1.

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Elisabeth Njamkepo
Jane Hawkey
  • Function : Author
Nancy Strockbine
  • Function : Author
Claire Jenkins
  • Function : Author
Kaisar A Talukder
  • Function : Author
Konstantin Kuleshov
  • Function : Author
Renáta Kolínská
  • Function : Author
Julie E Russell
  • Function : Author
Andreas Karas
  • Function : Author
Olivier Vandenberg
  • Function : Author
Alison E Mather
  • Function : Author
Carl J Mason
  • Function : Author
Andrew J Page
  • Function : Author
Anne-Laure Page
  • Function : Author
Thandavarayan Ramamurthy
  • Function : Author
Andrzej Gamian
  • Function : Author
Astrid Louise Wester
  • Function : Author
Martin Blaser
  • Function : Author
Cecilia Jernberg
  • Function : Author
Martin Aslett
  • Function : Author
Peter Roggentin
  • Function : Author
Angelika Fruth
  • Function : Author
Erick Denamur
Malabi Venkatesan
  • Function : Author
Hervé Bercovier
  • Function : Author
Ladaporn Bodhidatta
  • Function : Author
Chien-Shun Chiou
  • Function : Author
Gururaja P Pazhani
  • Function : Author
Analia V Ezernitchi
  • Function : Author
Simon R Harris
  • Function : Author
Hidemasa Izumiya
  • Function : Author
Agnieszka Korzeniowska-Kowal
  • Function : Author
Anna Lutyńska
  • Function : Author
Céline Langendorf
  • Function : Author
Monika Marejková
  • Function : Author
Lorea a M Peterson
  • Function : Author
Guillermo Perez-Perez
  • Function : Author
Alexander Podkolzin
  • Function : Author
German A Shipulin
  • Function : Author
Changyun Ye
  • Function : Author
Helena Žemličková
  • Function : Author
Mária Herpay
  • Function : Author
Kathryn E Holt
  • Function : Author

Abstract

Together with plague, smallpox and typhus, epidemics of dysentery have been a major scourge of human populations for centuries(1). A previous genomic study concluded that Shigella dysenteriae type 1 (Sd1), the epidemic dysentery bacillus, emerged and spread worldwide after the First World War, with no clear pattern of transmission(2). This is not consistent with the massive cyclic dysentery epidemics reported in Europe during the eighteenth and nineteenth centuries(1,3,4) and the first isolation of Sd1 in Japan in 1897(5). Here, we report a whole-genome analysis of 331 Sd1 isolates from around the world, collected between 1915 and 2011, providing us with unprecedented insight into the historical spread of this pathogen. We show here that Sd1 has existed since at least the eighteenth century and that it swept the globe at the end of the nineteenth century, diversifying into distinct lineages associated with the First World War, Second World War and various conflicts or natural disasters across Africa, Asia and Central America. We also provide a unique historical perspective on the evolution of antibiotic resistance over a 100-year period, beginning decades before the antibiotic era, and identify a prevalent multiple antibiotic-resistant lineage in South Asia that was transmitted in several waves to Africa, where it caused severe outbreaks of disease.
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Dates and versions

pasteur-01422023 , version 1 (12-03-2019)

Licence

Attribution - CC BY 4.0

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Elisabeth Njamkepo, Nizar Fawal, Alicia Tran-Dien, Jane Hawkey, Nancy Strockbine, et al.. Global phylogeography and evolutionary history of Shigella dysenteriae type 1.. Nature Microbiology, 2016, 1 (4), pp.16027. ⟨10.1038/NMICROBIOL.2016.27⟩. ⟨pasteur-01422023⟩
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