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Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

Nicholas A Feasey 1, 2, 3, * James Hadfield 2 Karen H Keddy 4, 5 Timothy J Dallman 6 Jan Jacobs 7, 8 Xiangyu Deng 9 Paul Wigley 3 Lars Barquist Gemma C Langridge 2 Theresa Feltwell 2 Simon Harris 2 Alison E Mather 2 Maria Fookes 2 Martin Aslett 2 Chisomo Msefula Samuel Kariuki Calman A Maclennan 2 Robert S Onsare François-Xavier Weill 10 Simon Le Hello 10 Anthony M Smith 5, 11 Michael Mcclelland 12 Prerak Desai 12 Christopher M Parry 1, 13, 14 John Cheesbrough Neil French 3 Josefina Campos 15 Jose A Chabalgoity Laura Betancor Katie L Hopkins Satheesh Nair 6 Tom J Humphrey Octavie Lunguya 16, 17 Tristan A Cogan 18 Milagritos D Tapia 19 Samba O Sow 20 Sharon M Tennant 19 Kristin Bornstein 19 Myron M Levine 19 Lizeth Lacharme-Lora 3 Dean B Everett 3 Robert A Kingsley 2, 21 Julian Parkhill 2 Robert S Heyderman 22 Gordon Dougan 2 Melita A Gordon 3 Nicholas R Thomson 2, 14
* Corresponding author
1 LSTM - Liverpool School of Tropical Medicine
2 The Wellcome Trust Sanger Institute [Cambridge]
3 University of Liverpool
4 WITS - University of the Witwatersrand [Johannesburg]
5 NICD - National Institute for Communicable Diseases [Johannesburg]
6 Public Health England [London]
7 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven
8 ITM - Institute of Tropical Medicine [Antwerp]
9 CDC - Centers for Disease Control and Prevention [Atlanta]
10 CNR-ESS - Centre National de Référence - National Reference Center Escherichia coli, Shigella et Salmonella
11 Plymouth University
12 UCI - University of California [Irvine]
13 LSHTM - London School of Hygiene and Tropical Medicine
14 Nagasaki University
15 ANLIS - Administración Nacional de Laboratorios e Institutos de Salud ‘Carlos Malbran'
16 INRB - Institut National de Recherche Biomédicale [Kinshasa]
17 UNIKIN - University of Kinshasa
18 University of Bristol [Bristol]
19 University of Maryland School of Medicine
20 Centre pour le Développement des Vaccins [Mali]
21 Institute of Food Research [Norwich]
22 UCL - University College of London [London]
Abstract : An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01421619
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Submitted on : Thursday, December 22, 2016 - 3:51:11 PM
Last modification on : Friday, November 26, 2021 - 4:00:01 PM

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Nicholas A Feasey, James Hadfield, Karen H Keddy, Timothy J Dallman, Jan Jacobs, et al.. Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.. Nature Genetics, Nature Publishing Group, 2016, 48 (10), pp.1211-7. ⟨10.1038/ng.3644⟩. ⟨pasteur-01421619⟩

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