Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. - Archive ouverte HAL Access content directly
Journal Articles Nature Genetics Year : 2016

Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

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Lars Barquist
  • Function : Author
Chisomo Msefula
  • Function : Author
Samuel Kariuki
  • Function : Author
Robert S Onsare
  • Function : Author
John Cheesbrough
  • Function : Author
Jose A Chabalgoity
  • Function : Author
Laura Betancor
  • Function : Author
Katie L Hopkins
  • Function : Author
Tom J Humphrey
  • Function : Author

Abstract

An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

Dates and versions

pasteur-01421619 , version 1 (22-12-2016)

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Cite

Nicholas A Feasey, James Hadfield, Karen H Keddy, Timothy J Dallman, Jan Jacobs, et al.. Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.. Nature Genetics, 2016, 48 (10), pp.1211-7. ⟨10.1038/ng.3644⟩. ⟨pasteur-01421619⟩

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