Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

Nicholas A Feasey 1, 2, 3, 4, * James Hadfield 2 Karen H Keddy 5, 6 Timothy J Dallman 7 Jan Jacobs 8, 9 Xiangyu Deng 10, 11 Paul Wigley 3 Lars Barquist 12 Gemma C Langridge 2 Theresa Feltwell 2 Simon Harris 2 Alison E Mather 2 Maria Fookes 2 Martin Aslett 2 Chisomo Msefula 4 Samuel Kariuki 13 Calman A Maclennan 2, 14 Robert S Onsare 13 François-Xavier Weill 15 Simon Le Hello 15 Anthony M Smith 6, 16 Michael Mcclelland 17 Prerak Desai 17 Christopher M Parry 1, 18, 19 John Cheesbrough 20 Neil French 3 Josefina Campos 21 Jose A Chabalgoity 22 Laura Betancor 22 Katie L Hopkins 23 Samuel Nair Satheesh Nair 7 Tom J Humphrey 24 Octavie Lunguya 25, 26 Tristan A Cogan 27 Milagritos D Tapia 28 Samba O Sow 29 Sharon M Tennant 28 Kristin Bornstein 28 Myron M Levine 28 Lizeth Lacharme-Lora 3 Dean B Everett 3 Robert A Kingsley 2, 30 Julian Parkhill 2 Robert S Heyderman 4, 31 Gordon Dougan 2 Melita A Gordon 3, 4 Nicholas R Thomson 2, 19
Abstract : An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.
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Article dans une revue
Nature Genetics, Nature Publishing Group, 2016, 48 (10), pp.1211-7. 〈10.1038/ng.3644〉
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Soumis le : jeudi 22 décembre 2016 - 15:51:11
Dernière modification le : mardi 16 janvier 2018 - 17:18:02

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Nicholas A Feasey, James Hadfield, Karen H Keddy, Timothy J Dallman, Jan Jacobs, et al.. Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.. Nature Genetics, Nature Publishing Group, 2016, 48 (10), pp.1211-7. 〈10.1038/ng.3644〉. 〈pasteur-01421619〉

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