Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.
Nicholas A Feasey
(1, 2, 3)
,
James Hadfield
(2)
,
Karen H Keddy
(4, 5)
,
Timothy J Dallman
(6)
,
Jan Jacobs
(7, 8)
,
Xiangyu Deng
(9)
,
Paul Wigley
(3)
,
Lars Barquist
,
Gemma C Langridge
(2)
,
Theresa Feltwell
(2)
,
Simon Harris
(2)
,
Alison E Mather
(2)
,
Maria Fookes
(2)
,
Martin Aslett
(2)
,
Chisomo Msefula
,
Samuel Kariuki
,
Calman A Maclennan
(2)
,
Robert S Onsare
,
François-Xavier Weill
(10)
,
Simon Le Hello
(10)
,
Anthony M Smith
(5, 11)
,
Michael Mcclelland
(12)
,
Prerak Desai
(12)
,
Christopher M Parry
(1, 13, 14)
,
John Cheesbrough
,
Neil French
(3)
,
Josefina Campos
(15)
,
Jose A Chabalgoity
,
Laura Betancor
,
Katie L Hopkins
,
Satheesh Nair
(6)
,
Tom J Humphrey
,
Octavie Lunguya
(16, 17)
,
Tristan A Cogan
(18)
,
Milagritos D Tapia
(19)
,
Samba O Sow
(20)
,
Sharon M Tennant
(19)
,
Kristin Bornstein
(19)
,
Myron M Levine
(19)
,
Lizeth Lacharme-Lora
(3)
,
Dean B Everett
(3)
,
Robert A Kingsley
(2, 21)
,
Julian Parkhill
(2)
,
Robert S Heyderman
(22)
,
Gordon Dougan
(2)
,
Melita A Gordon
(3)
,
Nicholas R Thomson
(2, 14)
1
LSTM -
Liverpool School of Tropical Medicine
2 The Wellcome Trust Sanger Institute [Cambridge]
3 University of Liverpool
4 WITS - University of the Witwatersrand [Johannesburg]
5 NICD - National Institute for Communicable Diseases [Johannesburg]
6 Public Health England [London]
7 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven
8 ITM - Institute of Tropical Medicine [Antwerp]
9 CDC - Centers for Disease Control and Prevention [Atlanta]
10 CNR-ESS - Centre National de Référence - National Reference Center Escherichia coli, Shigella et Salmonella
11 Plymouth University
12 UC Irvine - University of California [Irvine]
13 LSHTM - London School of Hygiene and Tropical Medicine
14 Nagasaki University
15 ANLIS - Administración Nacional de Laboratorios e Institutos de Salud ‘Carlos Malbran'
16 INRB - Institut National de Recherche Biomédicale [Kinshasa]
17 UNIKIN - University of Kinshasa
18 University of Bristol [Bristol]
19 University of Maryland School of Medicine
20 Centre pour le Développement des Vaccins [Mali]
21 Institute of Food Research [Norwich]
22 UCL - University College of London [London]
2 The Wellcome Trust Sanger Institute [Cambridge]
3 University of Liverpool
4 WITS - University of the Witwatersrand [Johannesburg]
5 NICD - National Institute for Communicable Diseases [Johannesburg]
6 Public Health England [London]
7 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven
8 ITM - Institute of Tropical Medicine [Antwerp]
9 CDC - Centers for Disease Control and Prevention [Atlanta]
10 CNR-ESS - Centre National de Référence - National Reference Center Escherichia coli, Shigella et Salmonella
11 Plymouth University
12 UC Irvine - University of California [Irvine]
13 LSHTM - London School of Hygiene and Tropical Medicine
14 Nagasaki University
15 ANLIS - Administración Nacional de Laboratorios e Institutos de Salud ‘Carlos Malbran'
16 INRB - Institut National de Recherche Biomédicale [Kinshasa]
17 UNIKIN - University of Kinshasa
18 University of Bristol [Bristol]
19 University of Maryland School of Medicine
20 Centre pour le Développement des Vaccins [Mali]
21 Institute of Food Research [Norwich]
22 UCL - University College of London [London]
Nicholas A Feasey
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- Function : Correspondent author
- PersonId : 1001762
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Lars Barquist
- Function : Author
Chisomo Msefula
- Function : Author
Samuel Kariuki
- Function : Author
Robert S Onsare
- Function : Author
François-Xavier Weill
- Function : Author
- PersonId : 172023
- IdHAL : francois-xavier-weill
- IdRef : 144436825
John Cheesbrough
- Function : Author
Jose A Chabalgoity
- Function : Author
Laura Betancor
- Function : Author
Katie L Hopkins
- Function : Author
Tom J Humphrey
- Function : Author
Abstract
An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.