R. 1. Becker, K. Skaar, and E. , Metal limitation and toxicity at the interface between host and pathogen, FEMS Microbiology Reviews, vol.38, issue.6, pp.1235-1249, 2014.
DOI : 10.1111/1574-6976.12087

Y. Li and D. Zamble, Nickel Homeostasis and Nickel Regulation: An Overview, Chemical Reviews, vol.109, issue.10, pp.4617-4643, 2009.
DOI : 10.1021/cr900010n

S. Mulrooney and R. Hausinger, Nickel uptake and utilization by microorganisms, FEMS Microbiology Reviews, vol.27, issue.2-3, pp.239-261, 2003.
DOI : 10.1016/S0168-6445(03)00042-1

K. Higgins, C. Carr, and M. Maroney, Specific Metal Recognition in Nickel Trafficking, Biochemistry, vol.51, issue.40, pp.7816-7832, 2012.
DOI : 10.1021/bi300981m

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502001

J. Boer, S. Mulrooney, and R. Hausinger, Nickel-dependent metalloenzymes, Archives of Biochemistry and Biophysics, vol.544, pp.142-152, 2014.
DOI : 10.1016/j.abb.2013.09.002

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946514

J. Atherton, ???INDUCED GASTRO-DUODENAL DISEASES, Annual Review of Pathology: Mechanisms of Disease, vol.1, issue.1, pp.63-96, 2006.
DOI : 10.1146/annurev.pathol.1.110304.100125

N. Salama, M. Hartung, and A. Müller, Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori, Nature Reviews Microbiology, vol.17, issue.6, pp.385-399, 2013.
DOI : 10.1038/nrmicro3016

M. Amieva, R. Peek, and . Jr, Pathobiology of Helicobacter pylori???Induced Gastric Cancer, Gastroenterology, vol.150, issue.1, pp.64-78, 2016.
DOI : 10.1053/j.gastro.2015.09.004

K. Eaton, J. Gilbert, E. Joyce, A. Wanken, and T. Thevenot, In Vivo Complementation of ureB Restores the Ability of Helicobacter pylori To Colonize, Infection and Immunity, vol.70, issue.2, pp.771-778, 2002.
DOI : 10.1128/IAI.70.2.771-778.2002

M. Farrugia, L. Macomber, and R. Hausinger, Biosynthesis of the Urease Metallocenter, Journal of Biological Chemistry, vol.288, issue.19, pp.13178-13185, 2013.
DOI : 10.1074/jbc.R112.446526

K. Stingl and H. De-reuse, Staying alive overdosed: How does control urease activity?, International Journal of Medical Microbiology, vol.295, issue.5, pp.307-315, 2005.
DOI : 10.1016/j.ijmm.2005.06.006

F. Fischer and H. De-reuse, Adaptation of Helicobacter pylori Metabolism to Persistent Gastric Colonization, Helicobacter pylori Research: From Bench to Bedside, 2016.
DOI : 10.1007/978-4-431-55936-8_2

L. Hu and H. Mobley, Purification and N-terminal analysis of urease from Helicobacter pylori, Infect Immun, vol.58, pp.992-998, 1990.

J. Olson and R. Maier, Molecular Hydrogen as an Energy Source for Helicobacter pylori, Science, vol.298, issue.5599, pp.1788-1790, 2002.
DOI : 10.1126/science.1077123

A. Van-vliet, S. Poppelaars, B. Davies, J. Stoof, and S. Bereswill, NikR Mediates Nickel-Responsive Transcriptional Induction of Urease Expression in Helicobacter pylori, Infection and Immunity, vol.70, issue.6, pp.2846-2852, 2002.
DOI : 10.1128/IAI.70.6.2846-2852.2002

H. Lebrette, E. Borezée-durant, L. Martin, P. Richaud, B. Erba et al., Novel insights into nickel import in Staphylococcus aureus: the positive role of free histidine and structural characterization of a new thiazolidine-type nickel chelator, Metallomics, vol.20, issue.4, pp.613-621, 2015.
DOI : 10.1039/C4MT00295D

URL : https://hal.archives-ouvertes.fr/hal-01149525

H. Mobley, R. Garner, and P. Bauerfeind, Helicobacter pylori nickel-transport gene nixA: synthesis of catalytically active urease in Escherichia coli independent of growth conditions, Molecular Microbiology, vol.161, issue.1, pp.97-109, 1995.
DOI : 10.1016/0014-5793(91)80565-K

J. Fulkerson, R. Garner, and H. Mobley, Conserved Residues and Motifs in the NixA Protein ofHelicobacter pylori Are Critical for the High Affinity Transport of Nickel Ions, Journal of Biological Chemistry, vol.273, issue.1, pp.235-241, 1998.
DOI : 10.1074/jbc.273.1.235

L. Wolfram, E. Haas, and P. Bauerfeind, Nickel Represses the Synthesis of the Nickel Permease NixA of Helicobacter pylori, Journal of Bacteriology, vol.188, issue.4, pp.1245-1250, 2006.
DOI : 10.1128/JB.188.4.1245-1250.2006

H. Mobley, R. Garner, G. Chippendale, J. Gilbert, and A. Kane, Role of Hpn and NixA of Helicobacter pylori in Susceptibility and Resistance to Bismuth and Other Metal Ions, Helicobacter, vol.174, issue.8, pp.162-169, 1999.
DOI : 10.1038/379635a0

P. Bauerfeind, R. Garner, and H. Mobley, Allelic exchange mutagenesis of nixA in Helicobacter pylori results in reduced nickel transport and urease activity, Infect Immun, vol.64, pp.2877-2880, 1996.

K. Nolan, D. Mcgee, H. Mitchell, T. Harro, and J. , In Vivo Behavior of a Helicobacter pylori SS1 nixA Mutant with Reduced Urease Activity, Infection and Immunity, vol.70, issue.2, pp.685-691, 2002.
DOI : 10.1128/IAI.70.2.685-691.2002

G. Davis and H. Mobley, Contribution of dppA to Urease Activity in Helicobacter pylori 26695, Helicobacter, vol.179, issue.5, pp.416-423, 2005.
DOI : 10.1146/annurev.biophys.15.1.321

J. Hendricks and H. Mobley, Helicobacter pylori ABC transporter: effect of allelic exchange mutagenesis on urease activity., Journal of Bacteriology, vol.179, issue.18, pp.5892-5902, 1997.
DOI : 10.1128/jb.179.18.5892-5902.1997

D. Witte, C. Schulz, C. Smet, A. Malfertheiner, P. Haesebrouck et al., Other Helicobacters and gastric microbiota, Helicobacter, vol.7, pp.62-68, 2016.
DOI : 10.1111/hel.12307

J. Stoof, E. Kuipers, and A. Van-vliet, Characterization of NikR-responsive promoters of urease and metal transport genes of Helicobacter mustelae, BioMetals, vol.383, issue.Suppl 1, pp.145-159, 2010.
DOI : 10.1007/s10534-009-9275-7

S. Benoit, S. Seshadri, R. Lamichhane-khadka, and R. Maier, Helicobacter hepaticus NikR controls urease and hydrogenase activities via the NikABDE and HH0418 putative nickel import proteins, Microbiology, vol.159, issue.Pt_1, pp.136-146, 2013.
DOI : 10.1099/mic.0.062976-0

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542730

N. Salama, B. Shepherd, and S. Falkow, Global Transposon Mutagenesis and Essential Gene Analysis of Helicobacter pylori, Journal of Bacteriology, vol.186, issue.23, pp.7926-79357926, 2004.
DOI : 10.1128/JB.186.23.7926-7935.2004

D. Baltrus, M. Amieva, A. Covacci, T. Lowe, and D. Merrell, The Complete Genome Sequence of Helicobacter pylori Strain G27, Journal of Bacteriology, vol.191, issue.1, pp.447-448, 2009.
DOI : 10.1128/JB.01416-08

H. Staudenmaier, B. Van-hove, Z. Yaraghi, and V. Braun, Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli., Journal of Bacteriology, vol.171, issue.5, pp.2626-2633, 1989.
DOI : 10.1128/jb.171.5.2626-2633.1989

M. Jones, I. Ademi, X. Yin, Y. Gong, and D. Zamble, Nickel-responsive regulation of two novel Helicobacter pylori NikR-targeted genes, Metallomics, vol.136, issue.4, pp.662-673, 2015.
DOI : 10.1039/C4MT00210E

A. Debowski, J. Gauntlett, H. Li, T. Liao, and . Sehna-lm, : One-step Transformation for the Construction of Markerless Gene Deletions, Helicobacter, vol.14, issue.583, pp.435-443, 2012.
DOI : 10.1111/j.1523-5378.2012.00969.x

M. Langford, J. Zabaleta, A. Ochoa, T. Testerman, and D. Mcgee, In Vitro and In Vivo Complementation of the Helicobacter pylori Arginase Mutant Using an Intergenic Chromosomal Site, Helicobacter, vol.143, issue.5, pp.477-493, 2006.
DOI : 10.1016/S0016-5085(97)70155-0

A. Danielli, S. Romagnoli, D. Roncarati, L. Costantino, and I. Delany, Growth Phase and Metal-Dependent Transcriptional Regulation of the fecA Genes in Helicobacter pylori, Journal of Bacteriology, vol.191, issue.11, pp.3717-3725, 2009.
DOI : 10.1128/JB.01741-08

M. Shaik, L. Cendron, M. Salamina, M. Ruzzene, and G. Zanotti, periplasmic receptor CeuE (HP1561) modulates its nickel affinity via organic metallophores, Molecular Microbiology, vol.106, issue.4, pp.724-735, 2014.
DOI : 10.1111/mmi.12487

S. Bury-moné, S. Skouloubris, A. Labigne, and H. De-reuse, The Helicobacter pylori UreI protein: role in adaptation to acidity and identification of residues essential for its activity and for acid activation, Molecular Microbiology, vol.1994, issue.4, pp.1021-1034, 2001.
DOI : 10.1016/0378-1119(85)90120-9

S. Skouloubris, J. Thiberge, A. Labigne, and H. De-reuse, The Helicobacter pylori UreI protein is not involved in urease activity but is essential for bacterial survival in vivo, Infect Immun, vol.66, pp.4517-4521, 1998.

M. Shiloh, J. Ruan, and C. Nathan, Evaluation of bacterial survival and phagocyte function with a fluorescence-based microplate assay, Infect Immun, vol.65, pp.3193-3198, 1997.

F. Veyrier, D. Pletzer, C. Turenne, and M. Behr, Phylogenetic detection of horizontal gene transfer during the step-wise genesis of Mycobacterium tuberculosis, BMC Evolutionary Biology, vol.9, issue.1, 2009.
DOI : 10.1186/1471-2148-9-196

F. Veyrier, N. Biais, P. Morales, N. Belkacem, and C. Guilhen, Common Cell Shape Evolution of Two Nasopharyngeal Pathogens, PLOS Genetics, vol.106, issue.4, p.26162030, 2015.
DOI : 10.1371/journal.pgen.1005338.s006

URL : https://hal.archives-ouvertes.fr/pasteur-01352679

L. Wolfram and P. Bauerfeind, Conserved Low-Affinity Nickel-Binding Amino Acids Are Essential for the Function of the Nickel Permease NixA of Helicobacter pylori, Journal of Bacteriology, vol.184, issue.5, pp.1438-1443, 2002.
DOI : 10.1128/JB.184.5.1438-1443.2002

D. Mcgee, J. Zabaleta, R. Viator, T. Testerman, and A. Ochoa, Purification and characterization of Helicobacter pylori arginase, RocF: unique features among the arginase superfamily, European Journal of Biochemistry, vol.129, issue.10, pp.1952-1962, 2004.
DOI : 10.1046/j.1523-5378.2002.00106.x

M. Dore, H. Lu, and D. Graham, eradication with triple therapy, Gut, vol.146, issue.Suppl 1, pp.870-878, 2016.
DOI : 10.1136/gutjnl-2015-311019

P. Chivers, Nickel recognition by bacterial importer proteins, Metallomics, vol.10, issue.4, pp.590-595, 2015.
DOI : 10.1039/c4mt00210e

URL : http://dro.dur.ac.uk/14428/1/14428.pdf?DDD7+DDD1+lgtc83+d700tmt

J. Stoof, E. Kuipers, G. Klaver, and A. Van-vliet, An ABC Transporter and a TonB Ortholog Contribute to Helicobacter mustelae Nickel and Cobalt Acquisition, Infection and Immunity, vol.78, issue.10, pp.4261-4267, 2010.
DOI : 10.1128/IAI.00365-10

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950367

A. Marais, G. Mendz, S. Hazell, and F. Megraud, Metabolism and genetics of Helicobacter pylori: the genome era, Microbiol Mol Biol Rev, vol.63, pp.642-674, 1999.

G. Karimova, A. Ullmann, and D. Ladant, Protein-protein interaction between Bacillus 41 stearothermophilus tyrosyl-tRNA synthetase, J Mol Microbiol Biotechnol, vol.3, pp.73-82, 2001.

J. Miller, A short Course in Bacterial Genetics: A laboratory manual and handbook for Escherichia coli and related bacteria. Cold Spring Harbor, 1992.

M. Mcclain, C. Shaffer, D. Israel, R. Peek, and T. Cover, Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer, BMC Genomics, vol.10, issue.1, 2009.
DOI : 10.1186/1471-2164-10-3

M. Farnbacher, T. Jahns, D. Willrodt, R. Daniel, and R. Haas, Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8, BMC Genomics, vol.11, issue.1, p.335, 2010.
DOI : 10.1186/1471-2164-11-335

A. Lee, J. O-'rourke, C. D. Ungria, M. Robertson, B. Daskalopoulos et al., A standardized mouse model of Helicobacter pylori infection: Introducing the Sydney strain, Gastroenterology, vol.112, issue.4, pp.1386-1397, 1997.
DOI : 10.1016/S0016-5085(97)70155-0

J. Tomb, O. White, A. Kerlavage, R. Clayton, and G. Sutton, The complete genome sequence of the gastric pathogen Helicobacter pylori, Nature, vol.388, issue.6642, pp.539-547, 1997.
DOI : 10.1038/41483

J. Sambrook and D. Russel, Molecular Cloning: a Laboratory Manual, 2001.

S. Bury-moné, S. Skouloubris, C. Dauga, J. Thiberge, and D. Dailidiene, Presence of Active Aliphatic Amidases in Helicobacter Species Able To Colonize the Stomach, Infection and Immunity, vol.71, issue.10, pp.5613-5622, 2003.
DOI : 10.1128/IAI.71.10.5613-5622.2003

I. Boneca, C. Ecobichon, C. Chaput, A. Mathieu, and S. Guadagnini, Development of Inducible Systems To Engineer Conditional Mutants of Essential Genes of Helicobacter pylori, Applied and Environmental Microbiology, vol.74, issue.7, pp.2095-2102, 2008.
DOI : 10.1128/AEM.01348-07

D. Leduc, J. Gallaud, K. Stingl, and H. De-reuse, Coupled Amino Acid Deamidase-Transport Systems Essential for Helicobacter pylori Colonization, Infection and Immunity, vol.78, issue.6, pp.2782-2792, 2010.
DOI : 10.1128/IAI.00149-10

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876568

S. Altschul, T. Madden, A. Schäffer, J. Zhang, and Z. Zhang, Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Research, vol.25, issue.17, pp.3389-3402, 1997.
DOI : 10.1093/nar/25.17.3389