R. Koup, J. Safrit, Y. Cao, C. Andrews, and G. Mcleod, Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome, Journal of virology, vol.68, pp.4650-4655, 1994.

P. Borrow, H. Lewicki, X. Wei, M. Horwitz, and N. Peffer, Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus, Nature Medicine, vol.69, issue.2, pp.205-211, 1997.
DOI : 10.1016/0022-1759(82)90269-1

J. Schmitz, M. Kuroda, S. Santra, V. Sasseville, and M. Simon, Control of Viremia in Simian Immunodeficiency Virus Infection by CD8+ Lymphocytes, Science, vol.283, issue.5403, pp.857-860, 1999.
DOI : 10.1126/science.283.5403.857

M. Boaz, A. Waters, S. Murad, P. Easterbrook, and A. Vyakarnam, Presence of HIV-1 Gag-Specific IFN-??+IL-2+ and CD28+IL-2+ CD4 T Cell Responses Is Associated with Nonprogression in HIV-1 Infection, The Journal of Immunology, vol.169, issue.11, pp.6376-6385, 2002.
DOI : 10.4049/jimmunol.169.11.6376

B. Youngblood, E. Wherry, and R. Ahmed, Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells, Current Opinion in HIV and AIDS, vol.7, issue.1, pp.50-57, 2012.
DOI : 10.1097/COH.0b013e32834ddcf2
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306172

L. Papagno, C. Spina, A. Marchant, M. Salio, and N. Rufer, Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection, PLoS Biology, vol.195, issue.2, p.20, 2004.
DOI : 10.1371/journal.pbio.0020020.t001
URL : http://doi.org/10.1371/journal.pbio.0020020

S. Migueles, A. Laborico, W. Shupert, M. Sabbaghian, and R. Rabin, HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors, Nature Immunology, vol.3, issue.11, pp.1061-1068, 2002.
DOI : 10.1038/ni845

M. Betts, M. Nason, S. West, D. Rosa, S. Migueles et al., HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells, Blood, vol.107, issue.12, pp.4781-4789, 2006.
DOI : 10.1182/blood-2005-12-4818
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895811

A. Saez-cirion, C. Lacabaratz, O. Lambotte, P. Versmisse, and A. Urrutia, HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype, Proceedings of the National Academy of Sciences, vol.104, issue.16, pp.6776-6781, 2007.
DOI : 10.1073/pnas.0611244104
URL : https://hal.archives-ouvertes.fr/pasteur-00142658

A. Saez-cirion, M. Sinet, S. Shin, A. Urrutia, and P. Versmisse, Heterogeneity in HIV Suppression by CD8 T Cells from HIV Controllers: Association with Gag-Specific CD8 T Cell Responses, The Journal of Immunology, vol.182, issue.12, pp.7828-7837, 2009.
DOI : 10.4049/jimmunol.0803928

S. Migueles, C. Osborne, C. Royce, A. Compton, and R. Joshi, Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control, Immunity, vol.29, issue.6, pp.1009-1021, 2008.
DOI : 10.1016/j.immuni.2008.10.010

A. Hersperger, F. Pereyra, M. Nason, K. Demers, and P. Sheth, Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control, PLoS Pathogens, vol.16, issue.5, p.1000917, 2010.
DOI : 10.1371/journal.ppat.1000917.s014

B. Emu, E. Sinclair, H. Hatano, A. Ferre, and B. Shacklett, HLA Class I-Restricted T-Cell Responses May Contribute to the Control of Human Immunodeficiency Virus Infection, but Such Responses Are Not Always Necessary for Long-Term Virus Control, Journal of Virology, vol.82, issue.11, pp.5398-5407, 2008.
DOI : 10.1128/JVI.02176-07

F. Pereyra, M. Addo, D. Kaufmann, Y. Liu, and T. Miura, Genetic and Immunologic Heterogeneity among Persons Who Control HIV Infection in the Absence of Therapy, The Journal of Infectious Diseases, vol.197, issue.4, pp.563-571, 2008.
DOI : 10.1086/526786

A. Saez-cirion, S. Shin, P. Versmisse, F. Barre-sinoussi, and G. Pancino, Ex vivo T cell???based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses, Nature Protocols, vol.178, issue.6, pp.1033-1041, 2010.
DOI : 10.1038/nprot.2006.268
URL : https://hal.archives-ouvertes.fr/pasteur-01420584

O. Doherty, U. Swiggard, W. Malim, and M. , Human Immunodeficiency Virus Type 1 Spinoculation Enhances Infection through Virus Binding, Journal of Virology, vol.74, issue.21, pp.10074-10080, 2000.
DOI : 10.1128/JVI.74.21.10074-10080.2000

B. Vingert, D. Benati, O. Lambotte, P. De-truchis, and L. Slama, HIV Controllers Maintain a Population of Highly Efficient Th1 Effector Cells in Contrast to Patients Treated in the Long Term, Journal of Virology, vol.86, issue.19, 2012.
DOI : 10.1128/JVI.00056-12
URL : https://hal.archives-ouvertes.fr/pasteur-00733917

S. Migueles, K. Weeks, E. Nou, A. Berkley, and J. Rood, Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy, Journal of Virology, vol.83, issue.22, pp.11876-11889, 2009.
DOI : 10.1128/JVI.01153-09
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772718

D. Souza, M. Altfeld, and M. , Measuring HIV-1-specific T cell immunity: how valid are current assays?, The Journal of infectious diseases, vol.197, pp.337-339, 2008.

H. Yang, H. Wu, G. Hancock, G. Clutton, and N. Sande, Antiviral Inhibitory Capacity of CD8+ T cells Predicts the Rate of CD4+ T-Cell Decline in HIV-1 Infection, Journal of Infectious Diseases, vol.206, issue.4, pp.552-561, 2012.
DOI : 10.1093/infdis/jis379

J. Almeida, D. Sauce, D. Price, L. Papagno, and S. Shin, Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity, Blood, vol.113, issue.25, pp.6351-6360, 2009.
DOI : 10.1182/blood-2009-02-206557
URL : https://hal.archives-ouvertes.fr/inserm-00668485