CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection

Abstract : The strong CD8+ T-cell-mediated HIV-1-suppressive capacity found in a minority of HIV-infected patients in chronic infection is associated with spontaneous control of viremia. However, it is still unclear whether such capacities were also present earlier in the CD8+ T cells from non controller patients and then lost as a consequence of uncontrolled viral replication. We studied 50 patients with primary HIV-1-infection to determine whether strong CD8+ T-cell-mediated HIV suppression is more often observed at that time. Despite high frequencies of polyfunctional HIV-specific CD8+ T-cells and a strong CD4+ T-helper response, CD8+ T-cells from 48 patients lacked strong HIV-suppressive capacities ex vivo. This indicates that the superior HIV-suppressive capacity of CD8+ T-cells from HIV controllers is not a general characteristic of the HIV-specific CD8+ T cell response in primary HIV infection.
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PLoS ONE, Public Library of Science, 2013, 8 (3), pp.e59767. 〈10.1371/journal.pone.0059767〉
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Dernière modification le : jeudi 24 mai 2018 - 11:26:01

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Camille Lecuroux, Isabelle Girault, Antoine Chéret, Pierre Versmisse, Georges Nembot, et al.. CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection. PLoS ONE, Public Library of Science, 2013, 8 (3), pp.e59767. 〈10.1371/journal.pone.0059767〉. 〈pasteur-01420538〉

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