Skip to Main content Skip to Navigation
Journal articles

CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection

Abstract : The strong CD8+ T-cell-mediated HIV-1-suppressive capacity found in a minority of HIV-infected patients in chronic infection is associated with spontaneous control of viremia. However, it is still unclear whether such capacities were also present earlier in the CD8+ T cells from non controller patients and then lost as a consequence of uncontrolled viral replication. We studied 50 patients with primary HIV-1-infection to determine whether strong CD8+ T-cell-mediated HIV suppression is more often observed at that time. Despite high frequencies of polyfunctional HIV-specific CD8+ T-cells and a strong CD4+ T-helper response, CD8+ T-cells from 48 patients lacked strong HIV-suppressive capacities ex vivo. This indicates that the superior HIV-suppressive capacity of CD8+ T-cells from HIV controllers is not a general characteristic of the HIV-specific CD8+ T cell response in primary HIV infection.
Document type :
Journal articles
Complete list of metadatas

Cited literature [22 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01420538
Contributor : Marie-Genevieve Guibert <>
Submitted on : Tuesday, December 20, 2016 - 4:59:07 PM
Last modification on : Wednesday, September 16, 2020 - 5:12:00 PM

File

journal.pone.0059767.PDF
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Camille Lecuroux, Isabelle Girault, Antoine Chéret, Pierre Versmisse, Georges Nembot, et al.. CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection. PLoS ONE, Public Library of Science, 2013, 8 (3), pp.e59767. ⟨10.1371/journal.pone.0059767⟩. ⟨pasteur-01420538⟩

Share

Metrics

Record views

424

Files downloads

1166