High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers

Olivier Lambotte 1, 2, 3 Justin Pollara 4 Faroudy Boufassa 5 Christiane Moog 6 Alain Venet 1 Barton F. Haynes 4 Jean-François Delfraissy 3, 1, 2 Asier Saez-Cirion 7 Guido Ferrari 8
1 INSERM U1012
2 UP11 - Université Paris-Sud - Paris 11
3 Service de médecine interne et maladies infectieuses
4 Duke School of Medicine
5 CESP - Centre de recherche en épidémiologie et santé des populations
6 Réplication virale, pathogenèse et immunité
7 Régulation des Infections Rétrovirales
8 Duke University Medical Center
Abstract : The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.
Keywords : Middle Aged Multivariate Analysis RNA Male Linear Models HLA-B Antigens HIV-1 HIV Infections HIV Long-Term Survivors Adult Antibodies Viral Antibody-Dependent Cell Cytotoxicity CD8-Positive T-Lymphocytes Female Viremia Humans
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PLoS ONE, Public Library of Science, 2013, 8 (9), pp.e74855. 〈10.1371/journal.pone.0074855〉
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Soumis le : mardi 20 décembre 2016 - 16:59:04
Dernière modification le : vendredi 17 février 2017 - 14:30:36
Document(s) archivé(s) le : lundi 20 mars 2017 - 16:30:42

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Olivier Lambotte, Justin Pollara, Faroudy Boufassa, Christiane Moog, Alain Venet, et al.. High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers. PLoS ONE, Public Library of Science, 2013, 8 (9), pp.e74855. 〈10.1371/journal.pone.0074855〉. 〈pasteur-01420536〉

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