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High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers

Abstract : The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01420536
Contributor : Marie-Genevieve Guibert <>
Submitted on : Tuesday, December 20, 2016 - 4:59:04 PM
Last modification on : Wednesday, September 16, 2020 - 5:11:59 PM
Long-term archiving on: : Monday, March 20, 2017 - 4:30:42 PM

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Olivier Lambotte, Justin Pollara, Faroudy Boufassa, Christiane Moog, Alain Venet, et al.. High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers. PLoS ONE, Public Library of Science, 2013, 8 (9), pp.e74855. ⟨10.1371/journal.pone.0074855⟩. ⟨pasteur-01420536⟩

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