NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers

Abstract : NKG2D mediates an important costimulatory pathway in CD8 T cells. In HIV infection, the authors found that NKG2D expression on both total CD8 and HIV-specific CD8 T cells was significantly lower in viremic patients than in HIV controllers. Antiretroviral therapy partially restored NKG2D expression on HIV-specific CD8 T cells. The authors observed a negative correlation between the respective expression levels of CD38 and NKG2D on total CD8 and HIV-specific CD8 T cells. The maintenance of NKG2D expression on CD8 T cells in HIV controllers may contribute to better cell function.
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Camille Lecuroux, Asier Saez-Cirion, Nicolas Noel, Lilia Ben-Lamine, Isabelle Girault, et al.. NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers. Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2013, 62 (1), pp.17--20. ⟨10.1097/QAI.0b013e318274579f⟩. ⟨pasteur-01420533⟩

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