 |
Journal articles
NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers
Abstract : NKG2D mediates an important costimulatory pathway in CD8 T cells. In HIV infection, the authors found that NKG2D expression on both total CD8 and HIV-specific CD8 T cells was significantly lower in viremic patients than in HIV controllers. Antiretroviral therapy partially restored NKG2D expression on HIV-specific CD8 T cells. The authors observed a negative correlation between the respective expression levels of CD38 and NKG2D on total CD8 and HIV-specific CD8 T cells. The maintenance of NKG2D expression on CD8 T cells in HIV controllers may contribute to better cell function.
Cited literature [22 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01420533
Contributor : Marie-Genevieve Guibert <>
Submitted on : Tuesday, May 16, 2017 - 1:15:29 PM
Last modification on : Wednesday, September 16, 2020 - 5:12:25 PM
Long-term archiving on: : Friday, August 18, 2017 - 12:15:09 AM
Contributor : Marie-Genevieve Guibert <>
Submitted on : Tuesday, May 16, 2017 - 1:15:29 PM
Last modification on : Wednesday, September 16, 2020 - 5:12:25 PM
Long-term archiving on: : Friday, August 18, 2017 - 12:15:09 AM
File
JAIDS Lambotte NKG2D revised.p...
Files produced by the author(s)
Licence
Distributed under a Creative Commons Attribution - NonCommercial - ShareAlike 4.0 International License