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Journal articles
NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers
Abstract : NKG2D mediates an important costimulatory pathway in CD8 T cells. In HIV infection, the authors found that NKG2D expression on both total CD8 and HIV-specific CD8 T cells was significantly lower in viremic patients than in HIV controllers. Antiretroviral therapy partially restored NKG2D expression on HIV-specific CD8 T cells. The authors observed a negative correlation between the respective expression levels of CD38 and NKG2D on total CD8 and HIV-specific CD8 T cells. The maintenance of NKG2D expression on CD8 T cells in HIV controllers may contribute to better cell function.
Cited literature [22 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01420533
Contributor : Marie-Genevieve Guibert Connect in order to contact the contributor
Submitted on : Tuesday, May 16, 2017 - 1:15:29 PM
Last modification on : Thursday, October 21, 2021 - 5:11:58 AM
Long-term archiving on: : Friday, August 18, 2017 - 12:15:09 AM
Contributor : Marie-Genevieve Guibert Connect in order to contact the contributor
Submitted on : Tuesday, May 16, 2017 - 1:15:29 PM
Last modification on : Thursday, October 21, 2021 - 5:11:58 AM
Long-term archiving on: : Friday, August 18, 2017 - 12:15:09 AM
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