F. Barre-sinoussi, J. C. Chermann, F. Rey, M. T. Nugeyre, S. Chamaret et al., Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS), Science, vol.220, issue.4599, pp.868-871, 1983.
DOI : 10.1126/science.6189183

S. G. Deeks, B. Autran, B. Berkhout, M. Benkirane, S. Cairns et al., Towards an HIV cure: a global scientific strategy, Nature Reviews Immunology, vol.2, issue.8, pp.607-614
DOI : 10.1038/nri3262

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595991

G. Hutter, D. Nowak, M. Mossner, S. Ganepola, A. Mussig et al., Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation, N Engl J Med, vol.3607, pp.692-698, 2009.

K. Allers, G. Hutter, J. Hofmann, C. Loddenkemper, K. Rieger et al., Evidence for the cure of HIV infection by CCR5??32/??32 stem cell transplantation, Blood, vol.117, issue.10, pp.2791-2799, 2011.
DOI : 10.1182/blood-2010-09-309591

S. A. Yukl, E. Boritz, M. Busch, C. Bentsen, T. W. Chun et al., Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient, PLoS Pathogens, vol.13, issue.5, p.1003347
DOI : 10.1371/journal.ppat.1003347.t004

A. Saez-cirion and G. Pancino, 2013 HIV controllers: a genetically determined or inducible phenotype?, Immunol Rev, vol.254

J. W. Mellors, C. R. Rinaldo, . Jr, P. Gupta, R. M. White et al., Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma, Science, vol.272, issue.5265, pp.1167-1170
DOI : 10.1126/science.272.5265.1167

J. V. Giorgi, L. E. Hultin, J. A. Mckeating, T. D. Johnson, B. Owens et al., Shorter Survival in Advanced Human Immunodeficiency Virus Type 1 Infection Is More Closely Associated with T Lymphocyte Activation than with Plasma Virus Burden or Virus Chemokine Coreceptor Usage, The Journal of Infectious Diseases, vol.179, issue.4, pp.859-870, 1999.
DOI : 10.1086/314660

A. E. Sousa, J. Carneiro, M. Meier-schellersheim, Z. Grossman, and R. M. Victorino, CD4 T Cell Depletion Is Linked Directly to Immune Activation in the Pathogenesis of HIV-1 and HIV-2 but Only Indirectly to the Viral Load, The Journal of Immunology, vol.169, issue.6, pp.3400-3406, 2002.
DOI : 10.4049/jimmunol.169.6.3400

M. D. Hazenberg, S. A. Otto, B. H. Van-benthem, M. T. Roos, R. A. Coutinho et al., Persistent immune activation in HIV-1 infection is associated with progression to AIDS, AIDS, vol.17, issue.13, pp.1881-1888, 2003.
DOI : 10.1097/00002030-200309050-00006

M. Paiardini and M. Müller-trutwin, HIV-associated chronic immune activation, Immunological Reviews, vol.330, issue.Suppl 3, pp.78-101, 2013.
DOI : 10.1111/imr.12079

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729961

M. P. Martin, Y. Qi, X. Gao, E. Yamada, J. N. Martin et al., Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1, Nature Genetics, vol.36, issue.6, pp.733-740, 2007.
DOI : 10.1038/ni845

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135476

G. Alter, S. Rihn, K. Walter, A. Nolting, M. Martin et al., HLA Class I Subtype-Dependent Expansion of KIR3DS1+ and KIR3DL1+ NK Cells during Acute Human Immunodeficiency Virus Type 1 Infection, Journal of Virology, vol.83, issue.13, pp.6798-6805, 2009.
DOI : 10.1128/JVI.00256-09

S. Kim, J. B. Sunwoo, L. Yang, T. Choi, Y. J. Song et al., HLA alleles determine differences in human natural killer cell responsiveness and potency, Proceedings of the National Academy of Sciences, vol.105, issue.12, pp.3053-3058, 2008.
DOI : 10.1182/blood-2004-12-4825

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268583

L. Fadda, G. Borhis, P. Ahmed, K. Cheent, S. V. Pageon et al., Peptide antagonism as a mechanism for NK cell activation, Proceedings of the National Academy of Sciences, vol.7, issue.4, pp.10160-10165
DOI : 10.1038/nri1250

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890497

H. Thananchai, G. Gillespie, M. P. Martin, A. Bashirova, N. Yawata et al., Cutting Edge: Allele-Specific and Peptide-Dependent Interactions between KIR3DL1 and HLA-A and HLA-B, The Journal of Immunology, vol.178, issue.1, pp.33-3717833, 2007.
DOI : 10.4049/jimmunol.178.1.33

J. P. Vivian, R. C. Duncan, R. Berry, G. M. O-'connor, H. H. Reid et al., Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B, Nature, vol.35, issue.7373, pp.401-405, 2011.
DOI : 10.1038/nature10517

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723390

G. Alter, D. Heckerman, A. Schneidewind, L. Fadda, C. M. Kadie et al., HIV-1 adaptation to NK-cell-mediated immune pressure, Nature, vol.294, issue.7358, pp.96-100, 2011.
DOI : 10.1038/nature10237

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194000

S. A. Migueles, M. S. Sabbaghian, W. L. Shupert, M. P. Bettinotti, F. M. Marincola et al., HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors, Proceedings of the National Academy of Sciences, vol.375, issue.6532, pp.2709-2714, 2000.
DOI : 10.1038/375606a0

F. Pereyra, X. Jia, P. J. Mclaren, A. Telenti, P. I. De-bakker et al., The major genetic determinants of HIV-1 control affect HLA class I peptide presentation, Science, vol.330, pp.1551-1557, 2010.

A. Saez-cirion, C. Lacabaratz, O. Lambotte, P. Versmisse, A. Urrutia et al., HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype, Proceedings of the National Academy of Sciences, vol.1, issue.4, pp.6776-6781, 2007.
DOI : 10.1128/JVI.77.4.2550-2558.2003

URL : https://hal.archives-ouvertes.fr/pasteur-00142658

A. E. Fenton-may, O. Dibben, T. Emmerich, H. Ding, K. Pfafferott et al., Relative resistance of HIV-1 founder viruses to control by interferon-alpha, Retrovirology, vol.10, issue.1, pp.146-156
DOI : 10.1016/j.vaccine.2008.11.084

Y. J. Seo and B. Hahm, Type I Interferon Modulates the Battle of Host Immune System Against Viruses, Adv Appl Microbiol, vol.73, issue.10, pp.83-10110
DOI : 10.1016/S0065-2164(10)73004-5

A. T. Haase, Targeting early infection to prevent HIV-1 mucosal transmission, Nature, vol.183, issue.7286, pp.217-223, 2010.
DOI : 10.1038/nature08757

D. Favre, J. Mold, P. W. Hunt, B. Kanwar, P. Loke et al., 3- dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease, Tryptophan catabolism by indoleamine Sci Transl Med, vol.23000632, issue.2, pp.32-36, 2010.

J. P. Herbeuval, J. Nilsson, A. Boasso, A. W. Hardy, M. J. Kruhlak et al., Differential expression of IFN-?? and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients, Proceedings of the National Academy of Sciences, vol.45, issue.1, pp.7000-7005, 2006.
DOI : 10.1002/1097-0320(20010901)45:1<37::AID-CYTO1142>3.0.CO;2-E

B. Malleret, B. Maneglier, I. Karlsson, P. Lebon, M. Nascimbeni et al., Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression, Blood, vol.112, issue.12, pp.4598-4608, 2008.
DOI : 10.1182/blood-2008-06-162651

URL : https://hal.archives-ouvertes.fr/hal-00345337

L. Barblu, K. Machmach, C. Gras, J. F. Delfraissy, F. Boufassa et al., Plasmacytoid Dendritic Cells (pDCs) From HIV Controllers Produce Interferon-?? and Differentiate Into Functional Killer pDCs Under HIV Activation, The Journal of Infectious Diseases, vol.206, issue.5, pp.790-801
DOI : 10.1093/infdis/jis384

K. Machmach, M. Leal, C. Gras, P. Viciana, M. Genebat et al., Plasmacytoid Dendritic Cells Reduce HIV Production in Elite Controllers, Journal of Virology, vol.86, issue.8, pp.4245-4252
DOI : 10.1128/JVI.07114-11

URL : https://hal.archives-ouvertes.fr/hal-00669899

A. Bergamaschi, A. David, L. Rouzic, E. Nisole, S. Barre-sinoussi et al., The CDK Inhibitor p21Cip1/WAF1 Is Induced by Fc??R Activation and Restricts the Replication of Human Immunodeficiency Virus Type 1 and Related Primate Lentiviruses in Human Macrophages, Journal of Virology, vol.83, issue.23, pp.12253-12265, 2009.
DOI : 10.1128/JVI.01395-09

A. Krupp, K. R. Mccarthy, M. Ooms, M. Letko, J. S. Morgan et al., 2013 APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host, PLoS Pathog, vol.9

M. H. Malim and P. Bieniasz, 2012 HIV Restriction Factors and Mechanisms of Evasion
DOI : 10.1101/cshperspect.a006940

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331687

D. Pasquale, M. Kourteva, Y. Allos, T. D-'aquila, and R. T. , 2013 Lower HIV Provirus Levels Are Associated with More APOBEC3G Protein in Blood Resting Memory CD4+ T Lymphocytes of Controllers In Vivo, PLoS One, vol.8

S. Sewram, R. Singh, E. Kormuth, L. Werner, K. Mlisana et al., Human TRIM5?? Expression Levels and Reduced Susceptibility to HIV???1 Infection, The Journal of Infectious Diseases, vol.199, issue.11, pp.1657-1663, 2009.
DOI : 10.1086/598861

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725358

M. Rotger, K. K. Dang, J. Fellay, E. L. Heinzen, S. Feng et al., Genome-Wide mRNA Expression Correlates of Viral Control in CD4+ T-Cells from HIV-1-Infected Individuals, PLoS Pathogens, vol.4, issue.2, p.1000781, 2010.
DOI : 10.1371/journal.ppat.1000781.s015

W. A. Paxton, S. R. Martin, D. Tse, T. R. O-'brien, J. Skurnick et al., Relative resistance to HIV???1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high???risk sexual exposures, Nature Medicine, vol.27, issue.4, pp.412-417, 1996.
DOI : 10.1056/NEJM199501263320401

A. Saez-cirion, P. Versmisse, L. X. Truong, L. A. Chakrabarti, W. Carpentier et al., Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks, Retrovirology, vol.3, issue.1, pp.81-1742, 2006.
DOI : 10.1186/1742-4690-3-81

URL : https://hal.archives-ouvertes.fr/inserm-00122137

H. Chen, C. Li, J. Huang, T. Cung, K. Seiss et al., CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21, Journal of Clinical Investigation, vol.121, issue.4, pp.1549-1560
DOI : 10.1172/JCI44539DS1

A. Saez-cirion, C. Hamimi, A. Bergamaschi, A. David, P. Versmisse et al., Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers, Blood, vol.118, issue.4, 2011.
DOI : 10.1182/blood-2010-12-327106

URL : https://hal.archives-ouvertes.fr/pasteur-01420583

&. Ho and D. D. , Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome, J Virol, vol.68, pp.4650-4655, 1994.

P. Borrow, H. Lewicki, X. Wei, M. S. Horwitz, N. Peffer et al., Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus, Nature Medicine, vol.69, issue.2, pp.205-211, 1997.
DOI : 10.1016/0022-1759(82)90269-1

P. Kiepiela, K. Ngumbela, C. Thobakgale, D. Ramduth, I. Honeyborne et al., CD8+ T-cell responses to different HIV proteins have discordant associations with viral load, Nature Medicine, vol.53, issue.1, pp.46-53, 1520.
DOI : 10.1038/nm1520

A. Okoye, H. Park, M. Rohankhedkar, L. Coyne-johnson, R. Lum et al., lymphocyte depletion but does not account for accelerated SIV pathogenesis, The Journal of Experimental Medicine, vol.162, issue.7, pp.1575-1588, 2009.
DOI : 10.1073/pnas.0308425101

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715089

X. Jin, D. E. Bauer, S. E. Tuttleton, S. Lewin, A. Gettie et al., T Cell Depletion in Simian Immunodeficiency Virus???infected Macaques, The Journal of Experimental Medicine, vol.41, issue.6, pp.991-998, 1999.
DOI : 10.1007/BF00918085

J. E. Schmitz, M. A. Simon, M. J. Kuroda, M. A. Lifton, M. W. Ollert et al., A Nonhuman Primate Model for the Selective Elimination of CD8+ Lymphocytes Using a Mouse-Human Chimeric Monoclonal Antibody, The American Journal of Pathology, vol.154, issue.6, pp.1923-1932, 1999.
DOI : 10.1016/S0002-9440(10)65450-8

F. Cocchi, A. L. Devico, A. Garzino-demo, S. K. Arya, R. C. Gallo et al., Identification of RANTES, MIP-1alpha, and MIP-1beta as the Major HIV-Suppressive Factors Produced by CD8+ T Cells, Science, vol.270, issue.5243, pp.1811-1815, 1995.
DOI : 10.1126/science.270.5243.1811

C. M. Walker, D. J. Moody, D. P. Stites, and J. Levy, CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication, Science, vol.234, issue.4783, pp.1563-1566
DOI : 10.1126/science.2431484

D. Kagi, B. Ledermann, K. Burki, H. Hengartner, and R. M. Zinkernagel, CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity, European Journal of Immunology, vol.73, issue.12, pp.3068-3072, 1994.
DOI : 10.1002/eji.1830241223

B. Lowin, M. Hahne, C. Mattmann, and J. Tschopp, Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways, Nature, vol.370, issue.6491, pp.650-652, 1994.
DOI : 10.1038/370650a0

B. Youngblood, E. J. Wherry, and R. Ahmed, Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells, Current Opinion in HIV and AIDS, vol.7, issue.1, pp.50-57, 2012.
DOI : 10.1097/COH.0b013e32834ddcf2

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306172

P. Champagne, G. S. Ogg, A. S. King, C. Knabenhans, K. Ellefsen et al., Skewed maturation of memory HIV-specific CD8 T lymphocytes, Nature, vol.41035065118, pp.106-111, 2001.

L. Papagno, C. A. Spina, A. Marchant, M. Salio, N. Rufer et al., Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection, PLoS Biology, vol.195, issue.2, 2004.
DOI : 10.1371/journal.pbio.0020020.t001

URL : http://doi.org/10.1371/journal.pbio.0020020

J. C. Gea-banacloche, S. A. Migueles, L. Martino, W. L. Shupert, A. C. Mcneil et al., Maintenance of Large Numbers of Virus-Specific CD8+ T Cells in HIV-Infected Progressors and Long-Term Nonprogressors, The Journal of Immunology, vol.165, issue.2, pp.1082-1092, 2000.
DOI : 10.4049/jimmunol.165.2.1082

M. R. Betts, M. C. Nason, S. M. West, S. C. De-rosa, S. A. Migueles et al., HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells, HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells, pp.4781-4789, 2005.
DOI : 10.1182/blood-2005-12-4818

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895811

S. A. Migueles, A. C. Laborico, W. L. Shupert, M. S. Sabbaghian, R. Rabin et al., HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors, Nature Immunology, vol.3, issue.11, pp.1061-1068, 2002.
DOI : 10.1038/ni845

A. R. Hersperger, G. Makedonas, and M. R. Betts, Flow cytometric detection of perforin upregulation in human CD8 T cells, Cytometry Part A, vol.25, issue.11, pp.1050-1057, 2008.
DOI : 10.1002/cyto.a.20596

S. A. Migueles, C. M. Osborne, C. Royce, A. A. Compton, R. P. Joshi et al., Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control, Immunity, vol.29, issue.6, pp.1009-1021, 2008.
DOI : 10.1016/j.immuni.2008.10.010

A. Saez-cirion, M. Sinet, S. Y. Shin, A. Urrutia, P. Versmisse et al., Heterogeneity in HIV Suppression by CD8 T Cells from HIV Controllers: Association with Gag-Specific CD8 T Cell Responses, The Journal of Immunology, vol.182, issue.12, pp.7828-78377828, 2009.
DOI : 10.4049/jimmunol.0803928

J. B. Sacha, C. Chung, E. G. Rakasz, S. P. Spencer, A. K. Jonas et al., Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression, The Journal of Immunology, vol.178, issue.5, pp.2746-2754, 2007.
DOI : 10.4049/jimmunol.178.5.2746

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520734/

C. Lecuroux, I. Girault, A. Cheret, P. Versmisse, G. Nembot et al., CD8 T-Cells from Most HIV-Infected Patients Lack Ex Vivo HIV-Suppressive Capacity during Acute and Early Infection, PLoS ONE, vol.113, issue.3, p.59767
DOI : 10.1371/journal.pone.0059767.s002

URL : https://hal.archives-ouvertes.fr/pasteur-01420538

K. Ladell, M. Hashimoto, M. C. Iglesias, P. G. Wilmann, J. E. Mclaren et al., A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8+ T Cells, Immunity, vol.38, issue.3, pp.425-436021
DOI : 10.1016/j.immuni.2012.11.021

H. Chen, Z. M. Ndhlovu, D. Liu, L. C. Porter, J. W. Fang et al., TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection, Nature Immunology, vol.172, issue.7, pp.691-700
DOI : 10.1038/ni.2342

J. Huang, Y. Yang, M. Al-mozaini, P. S. Burke, J. Beamon et al., Dendritic Cell Dysfunction During Primary HIV-1 Infection, Journal of Infectious Diseases, vol.204, issue.10, pp.1557-1562, 2011.
DOI : 10.1093/infdis/jir616

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192192

J. Huang, P. S. Burke, T. D. Cung, F. Pereyra, I. Toth et al., Leukocyte Immunoglobulin-Like Receptors Maintain Unique Antigen-Presenting Properties of Circulating Myeloid Dendritic Cells in HIV-1-Infected Elite Controllers, Journal of Virology, vol.84, issue.18, pp.9463-9471
DOI : 10.1128/JVI.01009-10

&. Deeks and S. G. , HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control, J Virol, vol.82, pp.5398-5407, 2008.

F. Pereyra, M. M. Addo, D. E. Kaufmann, Y. Liu, T. Miura et al., Genetic and Immunologic Heterogeneity among Persons Who Control HIV Infection in the Absence of Therapy, The Journal of Infectious Diseases, vol.197, issue.4, pp.563-571, 2008.
DOI : 10.1086/526786

Z. M. Ndhlovu, J. Proudfoot, K. Cesa, D. M. Alvino, A. Mcmullen et al., Elite Controllers with Low to Absent Effector CD8+ T Cell Responses Maintain Highly Functional, Broadly Directed Central Memory Responses, Journal of Virology, vol.86, issue.12, pp.6959-696900531
DOI : 10.1128/JVI.00531-12

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393560

L. Shan, K. Deng, N. S. Shroff, C. M. Durand, S. A. Rabi et al., Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation, Immunity, vol.36, issue.3, pp.491-501
DOI : 10.1016/j.immuni.2012.01.014

D. C. Douek, J. M. Brenchley, M. R. Betts, D. R. Ambrozak, B. J. Hill et al., HIV preferentially infects HIV-specific CD4+ T cells, HIV preferentially infects HIV-specific CD4+ T cells, pp.95-98, 2002.
DOI : 10.1038/417095a

A. Benlahrech, J. Harris, A. Meiser, T. Papagatsias, J. Hornig et al., Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1, Proceedings of the National Academy of Sciences, vol.110, issue.6, 2009.
DOI : 10.1182/blood-2007-02-062117

L. Papagno, G. Alter, L. Assoumou, R. L. Murphy, F. Garcia et al., Comprehensive analysis of virus-specific T-cells provides clues for the failure of therapeutic immunization with ALVAC-HIV vaccine, AIDS, vol.25, issue.1, pp.27-36, 2011.
DOI : 10.1097/QAD.0b013e328340fe55

M. S. De-souza, S. Ratto-kim, W. Chuenarom, A. Schuetz, S. Chantakulkij et al., The Thai Phase III Trial (RV144) Vaccine Regimen Induces T Cell Responses That Preferentially Target Epitopes within the V2 Region of HIV-1 Envelope, The Journal of Immunology, vol.188, issue.10, pp.5166-5176
DOI : 10.4049/jimmunol.1102756

J. Frater, F. Ewings, J. Hurst, H. Brown, N. Robinson et al., 2014 HIV-1 specific CD4 responses in primary HIV-1 infection predict disease progression in the SPARTAC trial, AIDS

N. Zheng, M. Fujiwara, T. Ueno, S. Oka, and M. Takiguchi, Strong Ability of Nef-Specific CD4+ Cytotoxic T Cells To Suppress Human Immunodeficiency Virus Type 1 (HIV-1) Replication in HIV-1-Infected CD4+ T Cells and Macrophages, Journal of Virology, vol.83, issue.15, pp.7668-767700513, 2009.
DOI : 10.1128/JVI.00513-09

V. Appay, The physiological role of cytotoxic CD4+ T-cells: the holy grail?, Clinical and Experimental Immunology, vol.172, issue.1, 2004.
DOI : 10.1084/jem.20031799

D. Z. Soghoian, H. Jessen, M. Flanders, K. Sierra-davidson, S. Cutler et al., 2012 HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome, Sci Transl Med, vol.43003165, issue.123, pp.123-125
DOI : 10.1126/scitranslmed.3003165

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918726

A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O-'callaghan, A. D. Kelleher et al., Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes, Proceedings of the National Academy of Sciences, vol.5, issue.5, pp.3382-3387, 2000.
DOI : 10.1038/8400

B. Emu, E. Sinclair, D. Favre, W. J. Moretto, P. Hsue et al., Phenotypic, Functional, and Kinetic Parameters Associated with Apparent T-Cell Control of Human Immunodeficiency Virus Replication in Individuals with and without Antiretroviral Treatment, Journal of Virology, vol.79, issue.22, pp.14169-14178, 2005.
DOI : 10.1128/JVI.79.22.14169-14178.2005

S. J. Potter, C. Lacabaratz, O. Lambotte, S. Perez-patrigeon, B. Vingert et al., Preserved Central Memory and Activated Effector Memory CD4+ T-Cell Subsets in Human Immunodeficiency Virus Controllers: an ANRS EP36 Study, Journal of Virology, vol.81, issue.24, pp.13904-13915, 2007.
DOI : 10.1128/JVI.01401-07

URL : https://hal.archives-ouvertes.fr/pasteur-00193768

B. Vingert, D. Benati, O. Lambotte, P. De-truchis, L. Slama et al., HIV Controllers Maintain a Population of Highly Efficient Th1 Effector Cells in Contrast to Patients Treated in the Long Term, Journal of Virology, vol.86, issue.19, pp.10661-10674
DOI : 10.1128/JVI.00056-12

URL : https://hal.archives-ouvertes.fr/pasteur-00733917

D. E. Kaufmann, D. G. Kavanagh, F. Pereyra, J. J. Zaunders, E. W. Mackey et al., Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction, Nature Immunology, vol.170, issue.11, pp.1246-1254, 2007.
DOI : 10.1038/ni1515

J. Van-grevenynghe, F. A. Procopio, Z. He, N. Chomont, C. Riou et al., Transcription factor FOXO3a controls the persistence of memory CD4+ T cells during HIV infection, Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection, pp.266-274, 2008.
DOI : 10.1038/nm1728

B. Vingert, S. Perez-patrigeon, P. Jeannin, O. Lambotte, F. Boufassa et al., HIV Controller CD4+ T Cells Respond to Minimal Amounts of Gag Antigen Due to High TCR Avidity, PLoS Pathogens, vol.77, issue.2, p.1000780
DOI : 10.1371/journal.ppat.1000780.s007

A. L. Ferre, P. W. Hunt, D. H. Mcconnell, M. M. Morris, J. C. Garcia et al., HIV Controllers with HLA-DRB1*13 and HLA-DQB1*06 Alleles Have Strong, Polyfunctional Mucosal CD4+ T-Cell Responses, HIV controllers with HLA- DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses, pp.11020-11029, 2010.
DOI : 10.1128/JVI.00980-10

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953185

M. Perreau, A. L. Savoye, E. De-crignis, J. M. Corpataux, R. Cubas et al., Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production, The Journal of Experimental Medicine, vol.9, issue.1, pp.143-156
DOI : 10.1126/science.278.5341.1291

Y. Xu, C. Weatherall, M. Bailey, S. Alcantara, R. De-rose et al., Simian Immunodeficiency Virus Infects Follicular Helper CD4 T Cells in Lymphoid Tissues during Pathogenic Infection of Pigtail Macaques, Journal of Virology, vol.87, issue.7, pp.3760-377302497, 2013.
DOI : 10.1128/JVI.02497-12

J. M. Brenchley, C. Vinton, B. Tabb, X. P. Hao, E. Connick et al., Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections, Blood, vol.120, issue.20, pp.4172-4181, 2012.
DOI : 10.1182/blood-2012-06-437608

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501715

J. J. Hong, P. K. Amancha, K. Rogers, A. A. Ansari, and F. Villinger, Spatial Alterations between CD4+ T Follicular Helper, B, and CD8+ T Cells during Simian Immunodeficiency Virus Infection: T/B Cell Homeostasis, Activation, and Potential Mechanism for Viral Escape, The Journal of Immunology, vol.188, issue.7, pp.3247-3256
DOI : 10.4049/jimmunol.1103138

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311732

M. Lindqvist, J. Van-lunzen, D. Z. Soghoian, B. D. Kuhl, S. Ranasinghe et al., Expansion of HIV-specific T follicular helper cells in chronic HIV infection, Journal of Clinical Investigation, vol.122, issue.9, pp.3271-3280
DOI : 10.1172/JCI64314DS1

C. Petrovas, T. Yamamoto, M. Y. Gerner, K. L. Boswell, K. Wloka et al., CD4 T follicular helper cell dynamics during SIV infection, Journal of Clinical Investigation, vol.122, issue.9, pp.3281-3294
DOI : 10.1172/JCI63039DS1

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428091

M. F. Chevalier and L. Weiss, 2012 The split personality of regulatory T cells in HIV infection, Blood

H. R. Epple, C. Loddenkemper, D. E. Kunkel, H. Trã-¶ger, J. Maul et al., Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART, Blood, vol.108, issue.9, pp.3072-3078, 2006.
DOI : 10.1182/blood-2006-04-016923

S. Dandekar, M. D. George, and A. J. Baumler, Th17 cells, HIV and the gut mucosal barrier, Current Opinion in HIV and AIDS, vol.5, issue.2, 2010.
DOI : 10.1097/COH.0b013e328335eda3

M. Angin, D. S. Kwon, H. Streeck, F. Wen, M. King et al., Preserved Function of Regulatory T Cells in Chronic HIV-1 Infection Despite Decreased Numbers in Blood and Tissue, Journal of Infectious Diseases, vol.205, issue.10, pp.1495-1500
DOI : 10.1093/infdis/jis236

P. W. Hunt, A. L. Landay, E. Sinclair, J. A. Martinson, H. Hatano et al., A Low T Regulatory Cell Response May Contribute to Both Viral Control and Generalized Immune Activation in HIV Controllers, PLoS ONE, vol.280, issue.1, p.15924
DOI : 10.1371/journal.pone.0015924.s001

R. E. Owen, J. W. Heitman, D. F. Hirschkorn, M. C. Lanteri, H. H. Biswas et al., HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses, AIDS, vol.24, issue.8, pp.1095-1105
DOI : 10.1097/QAD.0b013e3283377a1e

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972651

F. Simonetta, C. Lecuroux, I. Girault, C. Goujard, M. Sinet et al., Early and Long-Lasting Alteration of Effector CD45RA???Foxp3high Regulatory T-Cell Homeostasis During HIV Infection, The Journal of Infectious Diseases, vol.205, issue.10, pp.1510-1519
DOI : 10.1093/infdis/jis235

URL : https://hal.archives-ouvertes.fr/inserm-00865957

S. Elahi, W. L. Dinges, N. Lejarcegui, K. J. Laing, A. C. Collier et al., Protective HIV-specific CD8+ T cells evade Treg cell suppression, Nature Medicine, vol.173, issue.8, pp.989-995, 2011.
DOI : 10.1016/j.jim.2007.03.002

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324980

J. Overbaugh and L. Morris, 2012 The Antibody Response against HIV-1. Cold Spring Harb Perspect Med 2, a007039
DOI : 10.1101/cshperspect.a007039

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253031

D. H. Barouch, J. B. Whitney, B. Moldt, F. Klein, T. Y. Oliveira et al., 2013 Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys, Nature, vol.503, pp.224-228

T. Hirbod and K. Broliden, Mucosal immune responses in the genital tract of HIV-1-exposed uninfected women, Journal of Internal Medicine, vol.19, issue.1, pp.44-58, 2007.
DOI : 10.1016/S0264-410X(03)00295-0

R. Kaul, D. Trabattoni, J. J. Bwayo, D. Arienti, A. Zagliani et al., HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers, AIDS, vol.13, issue.1, pp.23-29, 1999.
DOI : 10.1097/00002030-199901140-00004

N. Ngo-giang-huong, D. Candotti, A. Goubar, B. Autran, M. Maynart et al., HIV Type 1-Specific IgG2 Antibodies: Markers of Helper T Cell Type 1 Response and Prognostic Marker of Long-Term Nonprogression, AIDS Research and Human Retroviruses, vol.17, issue.15, pp.1435-1446, 2001.
DOI : 10.1089/088922201753197105

M. A. French, R. J. Center, K. M. Wilson, I. Fleyfel, S. Fernandez et al., Isotype-switched immunoglobulin G antibodies to HIV Gag proteins may provide alternative or additional immune responses to ???protective??? human leukocyte antigen-B alleles in HIV controllers, AIDS, vol.27, issue.4, pp.519-528, 2013.
DOI : 10.1097/QAD.0b013e32835cb720

&. Ackerman and M. E. , 2013 Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV- 1 controllers, J Virol, pp.3130-3143

O. Lambotte, G. Ferrari, C. Moog, N. L. Yates, H. X. Liao et al., Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers, AIDS, vol.23, issue.8, pp.897-906, 2009.
DOI : 10.1097/QAD.0b013e328329f97d

URL : https://hal.archives-ouvertes.fr/inserm-00387059

Q. Liu, Y. Sun, S. Rihn, A. Nolting, P. N. Tsoukas et al., Matrix Metalloprotease Inhibitors Restore Impaired NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Human Immunodeficiency Virus Type 1 Infection, Journal of Virology, vol.83, issue.17, pp.8705-871202666, 2009.
DOI : 10.1128/JVI.02666-08

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738177

M. Bonsignori, J. Pollara, M. A. Moody, M. D. Alpert, X. Chen et al., Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family, Journal of Virology, vol.86, issue.21, pp.11521-115321001023, 1128.
DOI : 10.1128/JVI.01023-12

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486290

S. Rerks-ngarm, P. Pitisuttithum, S. Nitayaphan, J. Kaewkungwal, J. Chiu et al., Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand, New England Journal of Medicine, vol.361, issue.23, pp.2209-2220, 2009.
DOI : 10.1056/NEJMoa0908492

A. Allouch, A. David, S. M. Amie, H. Lahouassa, L. Chartier et al., p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway, Proceedings of the National Academy of Sciences, vol.16, issue.13, pp.3997-4006, 1306719110.
DOI : 10.1089/08892220050117014

URL : https://hal.archives-ouvertes.fr/pasteur-01420537

H. Stoiber, Z. Banki, D. Wilflingseder, and M. P. Dierich, Complement???HIV interactions during all steps of viral pathogenesis, Vaccine, vol.26, issue.24, pp.3-0264, 2008.
DOI : 10.1016/j.vaccine.2007.12.003

Z. Banki, W. Posch, A. Ejaz, V. Oberhauser, S. Willey et al., Complement as an Endogenous Adjuvant for Dendritic Cell-Mediated Induction of Retrovirus-Specific CTLs, PLoS Pathogens, vol.34, issue.15, p.1000891, 2010.
DOI : 10.1371/journal.ppat.1000891.s003

W. Posch, S. Cardinaud, C. Hamimi, A. Fletcher, A. Muhlbacher et al., Antibodies attenuate the capacity of dendritic cells to stimulate HIV-specific cytotoxic T lymphocytes, Journal of Allergy and Clinical Immunology, vol.130, issue.6, pp.1368-1374
DOI : 10.1016/j.jaci.2012.08.025

URL : https://hal.archives-ouvertes.fr/pasteur-01420581

I. Pandrea, E. Cornell, C. Wilson, R. M. Ribeiro, D. Ma et al., Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates, Blood, vol.120, issue.7, pp.1357-1366, 2012.
DOI : 10.1182/blood-2012-03-414706

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423778

O. M. Diop, M. J. Ploquin, L. Mortara, A. Faye, B. Jacquelin et al., Plasmacytoid Dendritic Cell Dynamics and Alpha Interferon Production during Simian Immunodeficiency Virus Infection with a Nonpathogenic Outcome, Journal of Virology, vol.82, issue.11, pp.5145-515202433, 2008.
DOI : 10.1128/JVI.02433-07

URL : https://hal.archives-ouvertes.fr/hal-00345347

V. Wijewardana, J. Kristoff, C. Xu, D. Ma, G. Haret-richter et al., Kinetics of Myeloid Dendritic Cell Trafficking and Activation: Impact on Progressive, Nonprogressive and Controlled SIV Infections, PLoS Pathogens, vol.38, issue.10, p.1003600, 2013.
DOI : 10.1371/journal.ppat.1003600.s009

L. E. Pereira, R. P. Johnson, and A. A. Ansari, Sooty mangabeys and rhesus macaques exhibit significant divergent natural killer cell responses during both acute and chronic phases of SIV infection, Cellular Immunology, vol.254, issue.1, pp.10-19, 2008.
DOI : 10.1016/j.cellimm.2008.06.006

B. Jacquelin, V. Mayau, B. Targat, A. S. Liovat, D. Kunkel et al., Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response, Journal of Clinical Investigation, vol.119, pp.3544-3555, 2009.
DOI : 10.1172/JCI40093DS1

M. C. Trutwin, Natural SIV Infection: Immunological Aspects, Models of Protection Against HIV/SIV: Avoiding AIDS in humans and monkeys, pp.47-80, 2011.

B. Descours, V. Avettand-fenoel, C. Blanc, A. Samri, A. Melard et al., Immune Responses Driven by Protective Human Leukocyte Antigen Alleles From Long-term Nonprogressors Are Associated With Low HIV Reservoir in Central Memory CD4 T Cells, Clinical Infectious Diseases, vol.54, issue.10, pp.1495-1503
DOI : 10.1093/cid/cis188

S. K. Choudhary, N. Vrisekoop, C. A. Jansen, S. A. Otto, H. Schuitemaker et al., Low Immune Activation despite High Levels of Pathogenic Human Immunodeficiency Virus Type 1 Results in Long-Term Asymptomatic Disease, Journal of Virology, vol.81, issue.16, pp.8838-8842, 2007.
DOI : 10.1128/JVI.02663-06

P. W. Hunt, J. Brenchley, E. Sinclair, J. M. Mccune, M. Roland et al., T Cell Count in HIV???Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy, The Journal of Infectious Diseases, vol.197, issue.1, pp.126-133, 2008.
DOI : 10.1086/524143

P. Y. Hsue, P. W. Hunt, A. Schnell, S. C. Kalapus, R. Hoh et al., Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis, AIDS, vol.23, issue.9, pp.1059-1067, 2009.
DOI : 10.1097/QAD.0b013e32832b514b

F. Pereyra, J. Lo, V. A. Triant, J. Wei, M. J. Buzon et al., Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers, AIDS, vol.26, issue.18, pp.2409-2412
DOI : 10.1097/QAD.0b013e32835a9950

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660105

S. Krishnan, E. M. Wilson, V. Sheikh, A. Rupert, D. Mendoza et al., 2013 Evidence for Innate Immune System Activation in HIV Type 1-Infected Elite Controllers, J Infect Dis

N. Noel, F. Boufassa, C. Lecuroux, A. Saez-cirion, C. Bourgeois et al., 2013 Elevated IP10 levels are associated with immune activation and low CD4+ T-cell counts in HIV controller patients, Aids
DOI : 10.1097/qad.0000000000000174

H. Hatano, E. L. Delwart, P. J. Norris, T. H. Lee, J. Dunn-williams et al., Evidence for Persistent Low-Level Viremia in Individuals Who Control Human Immunodeficiency Virus in the Absence of Antiretroviral Therapy, Journal of Virology, vol.83, issue.1, pp.329-33501763, 2009.
DOI : 10.1128/JVI.01763-08

F. Vigneault, M. Woods, M. J. Buzon, C. Li, F. Pereyra et al., Transcriptional Profiling of CD4 T Cells Identifies Distinct Subgroups of HIV-1 Elite Controllers, Journal of Virology, vol.85, issue.6, pp.3015-301901846, 2011.
DOI : 10.1128/JVI.01846-10

Y. Fukazawa, R. Lum, J. Y. Bae, A. A. Okoye, S. I. Hagen et al., CD8+ T cell responses restrict SIV replication to follivular helper T cells, 31st annual symposium on nonhuman primate models for AIDS, 2013.

I. Pandrea, T. Gaufin, J. M. Brenchley, R. Gautam, C. Monjure et al., Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion, The Journal of Immunology, vol.181, issue.10, pp.6687-6691, 2008.
DOI : 10.4049/jimmunol.181.10.6687

C. P. Passaes and A. Saez-cirion, 2014 HIV cure research: advances and prospects
DOI : 10.1016/j.virol.2014.02.021

URL : http://doi.org/10.1016/j.virol.2014.02.021

D. Persaud, H. Gay, C. Ziemniak, Y. H. Chen, M. Piatak et al., Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant, New England Journal of Medicine, vol.369, issue.19, pp.1828-1835, 1302976.
DOI : 10.1056/NEJMoa1302976

N. Ngo-giang-huong, C. Deveau, D. Silva, I. Pellegrin, I. Venet et al., Proviral HIV-1 DNA in subjects followed since primary HIV-1 infection who suppress plasma viral load after one year of highly active antiretroviral therapy, AIDS, vol.15, issue.6, pp.665-673, 2001.
DOI : 10.1097/00002030-200104130-00001

E. Delwart, M. Magierowska, M. Royz, B. Foley, L. Peddada et al., Homogeneous quasispecies in 16 out of 17 individuals during very early HIV-1 primary infection, AIDS, vol.16, issue.2, pp.189-195, 2002.
DOI : 10.1097/00002030-200201250-00007

S. Moir, C. M. Buckner, J. Ho, W. Wang, J. Chen et al., B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy, Blood, vol.116, issue.25, pp.5571-5579, 2010.
DOI : 10.1182/blood-2010-05-285528

A. Leone, L. J. Picker, and D. L. Sodora, IL-2, IL-7 and IL-15 as Immuno-Modulators During SIV/HIV Vaccination and Treatment, Current HIV Research, vol.7, issue.1, pp.83-90, 2009.
DOI : 10.2174/157016209787048519

Y. Levy, C. Lacabaratz, L. Weiss, J. P. Viard, C. Goujard et al., Enhanced T cell recovery in HIV-1???infected adults through IL-7 treatment, Journal of Clinical Investigation, vol.119, pp.997-1007, 2009.
DOI : 10.1172/JCI38052

URL : https://hal.archives-ouvertes.fr/inserm-00484803

Y. Levy, I. Sereti, G. Tambussi, J. P. Routy, J. D. Lelievre et al., Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study, Clinical Infectious Diseases, vol.55, issue.2, pp.291-300
DOI : 10.1093/cid/cis383

C. Vandergeeten, R. Fromentin, S. Dafonseca, M. B. Lawani, I. Sereti et al., Interleukin-7 promotes HIV persistence during antiretroviral therapy, Blood, vol.121, issue.21, pp.4321-4329
DOI : 10.1182/blood-2012-11-465625

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663425

D. M. Asmuth, R. L. Murphy, S. L. Rosenkranz, J. J. Lertora, S. Kottilil et al., Safety, Tolerability, and Mechanisms of Antiretroviral Activity of Pegylated Interferon Alfa???2a in HIV???1???Monoinfected Participants: A Phase II Clinical Trial, The Journal of Infectious Diseases, vol.201, issue.11, pp.1686-1696, 2010.
DOI : 10.1086/652420

L. Azzoni, A. S. Foulkes, E. Papasavvas, A. M. Mexas, K. M. Lynn et al., Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration, The Journal of Infectious Diseases, vol.207, issue.2, pp.213-222
DOI : 10.1093/infdis/jis663

F. Boue, J. Reynes, C. Rouzioux, D. Emilie, F. Souala et al., Alpha interferon administration during structured interruptions of combination antiretroviral therapy in patients with chronic HIV-1 infection: INTERVAC ANRS 105 trial, AIDS, vol.25, issue.1, pp.115-118, 2011.
DOI : 10.1097/QAD.0b013e328340a1e7

F. Porichis and D. E. Kaufmann, Role of PD-1 in HIV Pathogenesis and as Target for Therapy, Current HIV/AIDS Reports, vol.182, issue.1, pp.81-90, 2012.
DOI : 10.1007/s11904-011-0106-4

V. Velu, K. Titanji, B. Zhu, S. Husain, A. Pladevega et al., Enhancing SIV-specific immunity in vivo by PD-1 blockade, Nature, vol.369, issue.7235, pp.206-210, 2009.
DOI : 10.1038/nature07662

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753387

V. Velu, G. Mylvaganam, G. Freeman, R. Ahmed, and R. Amara, PD-1 blockade as an adjunct therapy for ART: Improves anti-SIV immunity, virologic response to ART and gut CD4 T cell restoration, 31st annual symposium on nonhuman primate models for AIDS, 2013.

N. Chomont, M. El-far, P. Ancuta, L. Trautmann, F. A. Procopio et al., HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation, Nature Medicine, vol.45, issue.8, pp.893-900, 1972.
DOI : 10.1038/nm.1972

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859814

D. Shetty, R. Velu, V. Titanji, K. Bosinger, S. E. Freeman et al., PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques, Journal of Clinical Investigation, vol.122, issue.5, pp.1712-1716, 2012.
DOI : 10.1172/JCI60612DS1

H. Hatano, Immune activation and HIV persistence, Current Opinion in HIV and AIDS, vol.8, issue.3, pp.211-216
DOI : 10.1097/COH.0b013e32835f9788

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041488

K. Sperber, G. Chiang, H. Chen, W. Ross, E. Chusid et al., Comparison of hydroxychloroquine with zidovudine in asymptomatic patients infected with human immunodeficiency virus type 1, Clinical Therapeutics, vol.19, issue.5, pp.913-923, 1997.
DOI : 10.1016/S0149-2918(97)80045-8

J. A. Martinson, C. J. Montoya, X. Usuga, R. Ronquillo, A. L. Landay et al., Chloroquine Modulates HIV-1-Induced Plasmacytoid Dendritic Cell Alpha Interferon: Implication for T-Cell Activation, Antimicrobial Agents and Chemotherapy, vol.54, issue.2, pp.871-88101246, 2010.
DOI : 10.1128/AAC.01246-09

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812138

S. M. Murray, C. M. Down, D. R. Boulware, W. M. Stauffer, W. P. Cavert et al., Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection, Journal of Virology, vol.84, issue.22, pp.12082-12086, 2010.
DOI : 10.1128/JVI.01466-10

N. I. Paton, R. L. Goodall, D. T. Dunn, S. Franzen, Y. Collaco-moraes et al., 2012 Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy: a randomized controlled trial, JAMA, vol.3086936, pp.353-361

N. T. Funderburg, Y. Jiang, S. M. Debanne, N. Storer, D. Labbato et al., 2013 Rosuvastatin Treatment Reduces Markers of Monocyte Activation in HIV-Infected Subjects on Antiretroviral Therapy, Clin Infect Dis

E. T. Overton, D. Kitch, C. A. Benson, P. W. Hunt, J. H. Stein et al., Effect of Statin Therapy in Reducing the Risk of Serious Non-AIDS-Defining Events and Nonaccidental Death, Clinical Infectious Diseases, vol.56, issue.10, pp.2013-1471
DOI : 10.1093/cid/cit053

L. D. Rasmussen, G. Kronborg, C. S. Larsen, C. Pedersen, J. Gerstoft et al., Statin Therapy and Mortality in HIV-Infected Individuals; A Danish Nationwide Population-Based Cohort Study, PLoS ONE, vol.305, issue.3, 2013.
DOI : 10.1371/journal.pone.0052828.s003

URL : http://doi.org/10.1371/journal.pone.0052828

K. Lichtenstein, R. Debes, and K. Wood, 2013 Statin Use Is Associated with Incident Diabetes Mellitus among Patients in the HIV Outpatient Study, 20th CROI. Abstract # 767

P. Morlat, E. Pereira, P. Clayette, N. Derreudre-bosquet, J. L. Ecobichon et al., p75 Receptor as a Marker of Progression in Treated HIV-Infected Patients, AIDS Research and Human Retroviruses, vol.24, issue.11, pp.1383-1389, 2008.
DOI : 10.1089/aid.2007.0293

URL : https://hal.archives-ouvertes.fr/inserm-00350155

J. Ananworanich, A. Schuetz, C. Vandergeeten, I. Sereti, M. De-souza et al., Impact of Multi-Targeted Antiretroviral Treatment on Gut T Cell Depletion and HIV Reservoir Seeding during Acute HIV Infection, PLoS ONE, vol.355, issue.3, p.33948
DOI : 10.1371/journal.pone.0033948.t002

K. C. Brown, K. B. Patterson, S. A. Malone, N. J. Shaheen, H. M. Prince et al., Single and Multiple Dose Pharmacokinetics of Maraviroc in Saliva, Semen, and Rectal Tissue of Healthy HIV-Negative Men, Journal of Infectious Diseases, vol.203, issue.10, pp.1484-1490, 2011.
DOI : 10.1093/infdis/jir059

M. C. Puertas, M. Massanella, J. M. Llibre, M. Ballestero, M. J. Buzon et al., Intensification of a raltegravirbased regimen with maraviroc in early HIV-1 infection, Aids, 2013.

P. W. Hunt, M. M. Lederman, and S. G. Deeks, 2013 Response: Maraviroc intensification and microbial translocation, Blood, vol.122
DOI : 10.1182/blood-2013-08-516930

C. Psomas, J. P. Lavigne, C. Barbuat, S. Trabelsi, J. Ghosn et al., Maraviroc-induced decrease in circulating bacterial products is not linked to an increase in immune activation in HIV-infected individuals, Blood, vol.122, issue.13, pp.2282-2283
DOI : 10.1182/blood-2013-06-507012

URL : https://hal.archives-ouvertes.fr/hal-00875241

M. Mohsen, T. Liegler, K. Harvill, and R. Hoh, Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers, PLoS Pathog, vol.9, 2013.

F. Garcia, N. Climent, A. C. Guardo, C. Gil, A. Leon et al., 2013 A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication, Sci Transl Med, vol.5, pp.166-162

C. Trumpfheller, M. P. Longhi, M. Caskey, J. Idoyaga, L. Bozzacco et al., Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity, Journal of Internal Medicine, vol.208, issue.2, pp.183-192
DOI : 10.1111/j.1365-2796.2011.02496.x

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261312

J. Zhou, A. K. Cheung, Z. Tan, H. Wang, W. Yu et al., PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice, Journal of Clinical Investigation, vol.123, issue.6, pp.2629-2642
DOI : 10.1172/JCI64704DS1

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668817

S. G. Hansen, J. C. Ford, M. S. Lewis, A. B. Ventura, C. M. Hughes et al., Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine, Nature, vol.81, issue.7348, pp.523-527, 2011.
DOI : 10.1038/nature10003

S. G. Hansen, J. B. Sacha, C. M. Hughes, J. C. Ford, B. J. Burwitz et al., Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms, Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms, p.1237874, 2013.
DOI : 10.1128/JVI.01816-07

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816976

A. Trkola, H. Kuster, P. Rusert, B. Joos, M. Fischer et al., Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies, Nature Medicine, vol.14, issue.6, pp.615-622, 2005.
DOI : 10.1016/j.virol.2004.05.022

P. L. Moore, E. S. Gray, C. K. Wibmer, J. N. Bhiman, M. Nonyane et al., Evolution of an HIV glycan???dependent broadly neutralizing antibody epitope through immune escape, Nature Medicine, vol.70, issue.11, pp.1688-1692
DOI : 10.1128/JVI.00239-07

P. D. Kwong and J. Mascola, Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies, Immunity, vol.37, issue.3, pp.412-425012
DOI : 10.1016/j.immuni.2012.08.012

URL : http://doi.org/10.1016/j.immuni.2012.08.012

H. X. Liao, R. Lynch, T. Zhou, F. Gao, S. M. Alam et al., Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus, Nature, vol.372, issue.7446, pp.469-476
DOI : 10.1038/nature12053

J. Jardine, J. P. Julien, S. Menis, T. Ota, O. Kalyuzhniy et al., Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors, Science, vol.60, issue.6, pp.711-716, 2013.
DOI : 10.1016/0092-8674(90)90344-E

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689846

A. T. Mcguire, S. Hoot, A. M. Dreyer, A. Lippy, A. Stuart et al., Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies, The Journal of Experimental Medicine, vol.67, issue.4, pp.655-663
DOI : 10.1126/science.1192819

D. H. Barouch, K. E. Stephenson, E. N. Borducchi, K. Smith, K. Stanley et al., Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys, Cell, vol.155, issue.3, pp.531-539061, 2013.
DOI : 10.1016/j.cell.2013.09.061