What is the significance of posttreatment control of HIV infection vis-à-vis functional cure?

Guido Vanham 1 Anne Buvé 1 Eric Florence 1 Carole Seguin-Devaux 2 Asier Sáez-Cirión 3
1 ITM - Institute of Tropical Medicine [Antwerp]
2 Centre de Recherche Public de la Santé
3 Régulation des Infections Rétrovirales
Abstract : An important challenge of HIV research today is ‘functional cure’ or HIV remission, that is interventions to keep viral load at low or undetectable level after interrupting combined antiretroviral treatment (cART). It has been suggested that so-called ‘elite controllers’ may provide important clues in this quest [1]. By definition elite controllers are able to maintain their viral loads below the clinical level of detection (<50 copies of viral RNA/ml) ‘spontaneously’ that is without ever being treated [2,3]. During the last few years reports have emerged on patients who were first treated with cART and who kept control over the virus after treatment interruption. These patients have been called ‘secondary controllers’ [4] or ‘posttreatment controllers’ (PTC) [5]. This PTC status may provide additional information to develop a functional cure.
Keywords : Withholding Treatment Anti-Retroviral Agents HIV-1 HIV Infections Humans Treatment Outcome Viral Load
Type de document :
Article dans une revue
AIDS, Lippincott, Williams & Wilkins, 2014, 28 (4), pp.603-5. 〈10.1097/QAD.0000000000000147〉
Liste complète des métadonnées

Littérature citée [19 références]  Voir  Masquer  Télécharger
https://hal-pasteur.archives-ouvertes.fr/pasteur-01420521
Contributeur : Marie-Genevieve Guibert <>
Soumis le : mardi 16 mai 2017 - 13:29:55
Dernière modification le : jeudi 7 février 2019 - 17:10:28
Document(s) archivé(s) le : vendredi 18 août 2017 - 00:25:45

Fichier

What is the significance of PT...
Fichiers produits par l'(les) auteur(s)

Licence

Distributed under a Creative Commons Paternité - Pas d'utilisation commerciale - Partage selon les Conditions Initiales 4.0 International License

Identifiants

Collections

PASTEUR

Citation

Guido Vanham, Anne Buvé, Eric Florence, Carole Seguin-Devaux, Asier Sáez-Cirión. What is the significance of posttreatment control of HIV infection vis-à-vis functional cure?. AIDS, Lippincott, Williams & Wilkins, 2014, 28 (4), pp.603-5. 〈10.1097/QAD.0000000000000147〉. 〈pasteur-01420521〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

159

Téléchargements de fichiers

156