Filling the gap: Micro-C accesses the nucleosomal fiber at 100-1000 bp resolution.

Julien Mozziconacci (1) , Romain Koszul (2)

1 LPTMC - Laboratoire de Physique Théorique de la Matière Condensée
2 Régulation spatiale des Génomes - Spatial Regulation of Genomes

The fine three-dimensional structure of the nucleosomal fiber has remained elusive to genome-wide chromosome conformation capture (3C) approaches. A new study mapping contacts at the single nucleosome level (Micro-C) reveals topological interacting domains along budding yeast chromosomes. These domains encompass one to five consecutive genes and are delimited by highly active promoters.

Domaines: Sciences du Vivant [q-bio]; Biologie cellulaire

Julien Mozziconacci, Romain Koszul. Filling the gap: Micro-C accesses the nucleosomal fiber at 100-1000 bp resolution.. Genome Biology, 2015, 16 (1), pp.169. ⟨10.1186/s13059-015-0744-8⟩. ⟨pasteur-01420328⟩